scholarly journals Pathological research on acute hepatic and renal tissue damage in Wistar rats induced by cocoa

2016 ◽  
Vol 5 (1) ◽  
pp. 51-58
Author(s):  
Chiedozie Onyejiaka Ibegbulem ◽  
Paul Chidoka Chikezie ◽  
Ezeikel Chinemerem Dike
Keyword(s):  
Tissue Damage ◽  
Wistar Rats ◽  
Renal Tissue ◽  
Pathological Research

Protection of endotoxin-induced oxidative renal tissue damage of rats by vitamin E or/and EGb 761 treatment

2005 ◽  
Vol 25 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Omer Coskun ◽  
Ferah Armutcu ◽  
Mehmet Kanter ◽  
Gamze Mocan Kuzey
Keyword(s):  
Vitamin E ◽  
Tissue Damage ◽  
Renal Tissue ◽  
Egb 761

scholarly journals Reduction of podocytes number in late diabetic alloxan nephropathy: prevention by glycemic control

2007 ◽  
Vol 22 (5) ◽  
pp. 337-341 ◽  
Author(s):  
Célia Sperandéo Macedo ◽  
Mauro Masson Lerco ◽  
Sônia Maria Capelletti ◽  
Reinaldo José Silva ◽  
Daniela de Oliveira Pinheiro ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Wistar Rats ◽  
Treated Group ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
Gbm Thickening ◽  
Diabetes Induction

PURPOSE: To determine podocyte number and GBM thickness in diabetic rats either under glycemic control or without glycemic control at 6 and 12 months after diabetes induction. METHODS: 100 wistar rats weighing 200-300g were divided into 6 groups: Normal group (N6 and N12- 25 rats); Diabetic group (D6 and D12- 25 rats), diabetic treated group ( DT 6 and DT 12- 25 rats) on insulin 1,8- 3,0 IU/Kg associated with acarbose (50mg to 100g of food) daily mixed in chow. Alloxan was injected intravenously in a dose of 42 mg/Kg of weight. Body weight, waterintake, 24-h diuresis, glycemia and glucosuria were determined before induction, 7 and 14 days after induction and monthly thereafter. Treatment started at day 14. Three groups were sacrificed at 6 months (N6,D6, DT6) and 3 groups at 12 months (N12, D12, DT12) with the renal tissue being prepared for electron microscopy. RESULTS: Glycemia in DT6¨and in DT12 was significantly different from that in D6 and D12 rats and similar to that in N6 and N12 animals. The number of podocytes in DT6 was not different from that in N6 and D6 (median = 11); the number of podocytes in DT12 (median = 11) differed from that in D12 (median = 8), but not from that in N12 (median = 11). GBM thickness in D6 (0.18 micrometers) was lower than in D12 (0.29 micrometers); while in DT6 (0.16 micrometers) it was lower than in D6 (0.18 micrometers). In DT12 (0.26 micrometers), it was lower than in D12 (0.29 micrometers). CONCLUSION: The control of hyperglycemia prevented GBM thickening in early and late (12 mo) alloxan diabetic nephropathy and podocyte number reduction.

Protective effects of pentoxifylline on cigarette smoking-induced renal tissue damage in rats

2010 ◽  
Vol 27 (4) ◽  
pp. 335-340 ◽  
Author(s):  
Cuneyd Ozkurkcugil ◽  
Melda Yardimoglu Yilmaz ◽  
Levend Ozkan ◽  
Sibel Kokturk ◽  
Tonguc Isken
Keyword(s):  
Cigarette Smoking ◽  
Tissue Damage ◽  
Renal Tissue ◽  
Protective Effects

scholarly journals Propofol effects on the morphology of rat testes subjected to testicular ischemiareperfusion

2012 ◽  
Vol 27 (2) ◽  
pp. 172-178 ◽  
Author(s):  
Antônio Urt Filho ◽  
Celso Massaschi Inouye ◽  
José Carlos Dorsa Vieira Pontes ◽  
Andréia Conceição Brochado Antoniolli Silva ◽  
Guilherme Viotto Rodrigues da Silva ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Spermatic Cord ◽  
Wistar Rats ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Seminiferous Tubules ◽  
Spermatic Cord Torsion ◽  
Significant Difference ◽  
Bilateral Orchiectomy ◽  
Testicular Ischemia

PURPOSE: To evaluate the effects of propofol as an inhibitor of tissue injury in testicular ischemia-reperfusion in rats. METHODS: 30 Wistar rats were assigned to one of three groups of 10 animals: G1, testicular exposure alone; G2 and G3: testicular ischemia caused by left spermatic cord torsion of 720º. In G3, propofol was administered intraperitoneally at 20 mg/kg/h 45 minutes after spermatic cord torsion. In G2 and G3, spermatic cords were detorsioned after 60 min. In all three groups, testes were subsequently repositioned in the scrotum. After 90 days, bilateral orchiectomy was performed for histological examination. RESULTS: No abnormalities in seminiferous tubules were found in G1. In G2, 86.6% of left testes exhibited abnormalities, in contrast with 67.8% for right testes. In G3, these proportions were 57.3% and 45.6%, respectively. A statistically significant difference was found between G2 and G3. CONCLUSION: Propofol reduced the tissue damage in rat testes subjected to ischemia-reperfusion caused by spermatic cord torsion.

Is enalapril adequate for the prevention of renal tissue damage caused by unilateral ureteral obstruction and/or hyperoxaluria?

2003 ◽  
Vol 31 (3) ◽  
pp. 212-217 ◽  
Author(s):  
T. Turan ◽  
J. G. van Harten ◽  
R. de Water ◽  
O. L. Tuncay ◽  
D. J. Kok
Keyword(s):  
Tissue Damage ◽  
Ureteral Obstruction ◽  
Renal Tissue ◽  
Unilateral Ureteral Obstruction

scholarly journals Mesenteric Lymph Drainage Alleviates Acute Kidney Injury Induced by Hemorrhagic Shock without Resuscitation

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Zi-Gang Zhao ◽  
Hong-Xia Zhu ◽  
Li-Min Zhang ◽  
Yu-Ping Zhang ◽  
Chun-Yu Niu
Keyword(s):  
Acute Kidney Injury ◽  
Hemorrhagic Shock ◽  
Tissue Damage ◽  
Kidney Injury ◽  
Renal Tissue ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Lymph Drainage ◽  
Mesenteric Lymph ◽  
2,3 Dpg

This study aimed to investigate the effect of mesenteric lymph drainage on the acute kidney injury induced by hemorrhagic shock without resuscitation. Eighteen male Wistar rats were randomly divided into sham, shock, and drainage groups. The hemorrhagic shock model (40 mmHg, 3 h) was established in shock and drainage groups; mesenteric lymph drainage was performed from 1 h to 3 h of hypotension in the drainage group. The results showed that renal tissue damage occurred; the levels of urea, creatinine, and trypsin in the plasma as well as intercellular adhesion molecule-1 (ICAM-1), receptor of advanced glycation end-products (RAGE), tumor necrosis factor-α(TNF-α), malondialdehyde (MDA), lactic acid (LA), and 2,3-DPG in the renal tissue were increased in the shock group after 3 h of hypotension. Mesenteric lymph drainage lessened the following: renal tissue damage; urea and trypsin concentrations in the plasma; ICAM-1, RAGE, TNF-α, MDA, and LA levels in the renal tissue. By contrast, mesenteric lymph drainage increased the 2,3-DPG level in the renal tissue. These findings indicated that mesenteric lymph drainage could relieve kidney injury caused by sustained hypotension, and its mechanisms involve the decrease in trypsin activity, suppression of inflammation, alleviation of free radical injury, and improvement of energy metabolism.

Renal Tissue Damage After Experimental Pyelonephritis: Role of Anti-Oxidants and Selective Cyclooxygenase-2 Inhibitors

2009 ◽  
Vol 5 ◽  
pp. S22
Author(s):  
Serhat Gurocak ◽  
Iyimser Ure ◽  
Ahmet Cumaoglu ◽  
Ipek Isik Gonul ◽  
Ilker Sen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Renal Tissue ◽  
Cyclooxygenase 2 ◽  
Experimental Pyelonephritis ◽  
Cyclooxygenase 2 Inhibitors

Fate of Vasopressin Perfused into Nephrons of Wistar and Brattleboro (Diabetes Insipidus) Rats

1980 ◽  
Vol 58 (2) ◽  
pp. 139-144 ◽  
Author(s):  
M. D. Lindheimer ◽  
A. Reinharz ◽  
A. Grandchamp ◽  
M. B. Vallotton
Keyword(s):  
Diabetes Insipidus ◽  
Wistar Rats ◽  
Rat Kidney ◽  
Renal Tissue ◽  
Tubular Secretion ◽  
Urinary Recovery ◽  
Contralateral Kidney ◽  
Linear Peptide ◽  
Lissamine Green ◽  
Distal Tubules

1. Iodinated vasopressin was microinjected into early proximal or distal tubules of Wistar and Brattleboro (diabetes insipidus) rats. Sites of infusion were determined by the lissamine green transit time method. 2. Urinary recovery of 125I after proximal and distal injections was 89 ± se 1·7% and 94 ± 1·0% in Wistar rats (corrected for inulin) and 81 ± 20 and 92 ± 2·0% in Brattleboro rats (uncorrected); injection of hormone into vascular stars resulted in similar 125I recoveries from punctured and contralateral kidneys. 3. Radioactive substances excreted after perfusing proximal and distal sites in Brattleboro animals, and 125I-labelled hormone added to urine from the contralateral kidney, bound similarly to a specific arginine vasopressin antiserum and demonstrated similar radioactive elution profiles after passage through Sephadex G25 columns. 4. Incubation of labelled and unlabelled vasopressin with rat kidney homogenates resulted in similar and complete degradation of the hormone. 5. Results indicate that most of the vasopressin injected into either proximal or distal nephrons enters the urine intact, and no evidence of tubular secretion was found when perfusing vascular stars. Enzymes in rat renal tissue degrade labelled vasopressin, but the ability of the proximal tubule to hydrolyse the 125I-labelled vasopressin is limited, especially when compared with that reported for several linear peptide hormones.

scholarly journals Age-dependent shifts in renal response to injury relate to altered BMP6/CTGF expression and signaling

2016 ◽  
Vol 311 (5) ◽  
pp. F926-F934 ◽  
Author(s):  
Lucas L. Falke ◽  
Hiroshi Kinashi ◽  
Amelie Dendooven ◽  
Roel Broekhuizen ◽  
Reinout Stoop ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tissue Damage ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Renal Tissue ◽  
Tissue Growth ◽  
Bmp Signaling ◽  
Obstructive Nephropathy ◽  
Young Mice

Age is associated with an increased prevalence of chronic kidney disease (CKD), which, through progressive tissue damage and fibrosis, ultimately leads to loss of kidney function. Although much effort is put into studying CKD development experimentally, age has rarely been taken into account. Therefore, we investigated the effect of age on the development of renal tissue damage and fibrosis in a mouse model of obstructive nephropathy (i.e., unilateral ureter obstruction; UUO). We observed that after 14 days, obstructed kidneys of old mice had more tubulointerstitial atrophic damage but less fibrosis than those of young mice. This was associated with reduced connective tissue growth factor (CTGF), and higher bone morphogenetic protein 6 (BMP6) expression and pSMAD1/5/8 signaling, while transforming growth factor-β expression and transcriptional activity were no different in obstructed kidneys of old and young mice. In vitro, CTGF bound to and inhibited BMP6 activity. In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 and lower CTGF expression.

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