Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case–control study in a Northern Indian population

2011 ◽  
Vol 304 (1-2) ◽  
pp. 67-70 ◽  
Author(s):  
B.I. Somarajan ◽  
J. Kalita ◽  
B. Mittal ◽  
U.K. Misra
Keyword(s):  
Indian Population ◽  
Hemorrhagic Stroke ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Stroke Patients ◽  
Mthfr C677t Polymorphism ◽  
Control Study

scholarly journals Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study

BMJ ◽  
2004 ◽  
Vol 328 (7455) ◽  
pp. 1535-1536 ◽  
Author(s):  
Peadar N Kirke ◽  
James L Mills ◽  
Anne M Molloy ◽  
Lawrence C Brody ◽  
Valerie B O'Leary ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Control Study

scholarly journals Association between MTHFR C677T polymorphism and the susceptibility to nonsyndromic cleft lip with or without cleft palate in Chinese Han population: a case-control study and meta-analysis

2021 ◽  
Author(s):  
Xuemei Lu ◽  
Xiaoling Deng ◽  
Tingying Liu ◽  
Qiufang Zhang ◽  
Mingyan Xu
Keyword(s):  
Cleft Lip ◽  
Case Control Study ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Chinese Han ◽  
Mthfr C677t Polymorphism ◽  
Han Population ◽  
Control Study

Abstract Background: Functional polymorphisms on methylenetetrahydrofolate reductase (MTHFR) gene are reported to be involved in the etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P), but the conclusions are still inconsistent. The aim of our study is to investigate the association between the susceptibility of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and MTHFR C677T polymorphism in Chinese Han population．Methods: A case-control study was performed, followed by a Meta-analysis. Electronic databases including PubMed, Embase, CNKI, VIP and Wanfang database were searched for relevant literature from inception of databases to November 2020. Meta-analysis was performed using Revman 5.3 and STATA 12.0 software. Results: The case-control study included 358 NSCL/P cases and 354 controls, which indicated that the variant T allele significantly increased NSCL/P risk in Southern China. Then, in the present Meta-analysis, a total of nine case-control studies with 1444 cases and 1555 controls were included. Overall, there was a significant association between MTHFR C677T polymorphism and NSCL/P susceptibility under all genetic models. The subgroup analysis of NSCL/P types showed significantly increased risk of CLO but not CPO or CLP. In terms of the stratified analysis by geographical location, a significantly association was observed in Southern China under all genetic models, while there was no significant association in Northern China. Sensitivity analyses, Begg's funnel plot and Egger’s regression test further suggest the stable and trustworthy of these results. Conclusion: MTHFR C677T polymorphism is associated with the risk of NSCL/P in Chinese Han population, especially increasing the risk of NSCL/P in southern Chinese Han populations.

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: The Croatian case–control study

2007 ◽  
Vol 40 (13-14) ◽  
pp. 981-985 ◽  
Author(s):  
Ante Reljic ◽  
Ana-Maria Simundic ◽  
Elizabeta Topic ◽  
Nora Nikolac ◽  
Danijel Justinic ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Methylenetetrahydrofolate Reductase ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Control Study

MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women

2013 ◽  
Vol 0 (0) ◽  
pp. 1-6 ◽  
Author(s):  
Manju Puri ◽  
Lovejeet Kaur ◽  
Gagandeep Kaur Walia ◽  
Rupak Mukhopadhhyay ◽  
Mohinder Pal Sachdeva ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Indian Women ◽  
Mthfr C677t Polymorphism ◽  
Recurrent Pregnancy Losses ◽  
Control Study

scholarly journals Disruptions of Anaerobic Gut Bacteria Are Associated with Stroke and Post-stroke Infection: a Prospective Case–Control Study

2020 ◽  
Author(s):  
Bastiaan W. Haak ◽  
Willeke F. Westendorp ◽  
Tjitske S. R. van Engelen ◽  
Xanthe Brands ◽  
Matthijs C. Brouwer ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Hemorrhagic Stroke ◽  
Case Control Study ◽  
Case Control ◽  
Gut Bacteria ◽  
Stroke Patients ◽  
Post Stroke ◽  
The Impact ◽  
Control Study ◽  
Prospective Case Control Study

Abstract In recent years, preclinical studies have illustrated the potential role of intestinal bacterial composition in the risk of stroke and post-stroke infections. The results of these studies suggest that bacteria capable of producing volatile metabolites, including trimethylamine-N-oxide (TMAO) and butyrate, play opposing, yet important roles in the cascade of events leading to stroke. However, no large-scale studies have been undertaken to determine the abundance of these bacterial communities in stroke patients and to assess the impact of disrupted compositions of the intestinal microbiota on patient outcomes. In this prospective case–control study, rectal swabs from 349 ischemic and hemorrhagic stroke patients (median age, 71 years; IQR: 67–75) were collected within 24 h of hospital admission. Samples were subjected to 16S rRNA amplicon sequencing and subsequently compared with samples obtained from 51 outpatient age- and sex-matched controls (median age, 72 years; IQR, 62–80) with similar cardiovascular risk profiles but without active signs of stroke. Plasma protein biomarkers were analyzed using a combination of nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry (LC-MS). Alpha and beta diversity analyses revealed higher disruption of intestinal communities during ischemic and hemorrhagic stroke compared with non-stroke matched control subjects. Additionally, we observed an enrichment of bacteria implicated in TMAO production and a loss of butyrate-producing bacteria. Stroke patients displayed two-fold lower plasma levels of TMAO than controls (median 1.97 vs 4.03 μM, Wilcoxon p < 0.0001). Finally, lower abundance of butyrate-producing bacteria within 24 h of hospital admission was an independent predictor of enhanced risk of post-stroke infection (odds ratio 0.77, p = 0.005), but not of mortality or functional patient outcome. In conclusion, aberrations in trimethylamine- and butyrate-producing gut bacteria are associated with stroke and stroke-associated infections.

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