Increased amyloid β protein levels in children and adolescents with Down syndrome

2007 ◽  
Vol 254 (1-2) ◽  
pp. 22-27 ◽  
Author(s):  
Pankaj D. Mehta ◽  
George Capone ◽  
Amy Jewell ◽  
Robert L. Freedland
Keyword(s):  
Down Syndrome ◽  
Children And Adolescents ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Β Protein

Increased plasma amyloid β protein 1–42 levels in Down syndrome

1998 ◽  
Vol 241 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Pankaj D Mehta ◽  
Arthur J Dalton ◽  
Sangita P Mehta ◽  
Kwang Soo Kim ◽  
Eugene A Sersen ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid β-Protein Levels under Hypoxic Conditions

2008 ◽  
Vol 283 (18) ◽  
pp. 11866-11875 ◽  
Author(s):  
Bin Zhang ◽  
Yuanlin Dong ◽  
Guohua Zhang ◽  
Robert D. Moir ◽  
Weiming Xia ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Caspase Activation ◽  
Protein Levels ◽  
Hypoxic Conditions ◽  
Inhalation Anesthetic ◽  
Β Protein

scholarly journals The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

2004 ◽  
Vol 279 (47) ◽  
pp. 49099-49104 ◽  
Author(s):  
Ju-Hyun Lee ◽  
Kwok-Fai Lau ◽  
Michael S. Perkinton ◽  
Claire L. Standen ◽  
Boris Rogelj ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Amyloid Β ◽  
Adaptor Protein ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Β Protein

Plasma amyloid β protein 1–42 levels are increased in old Down Syndrome but not in young Down Syndrome

2003 ◽  
Vol 342 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Pankaj D Mehta ◽  
Sangita P Mehta ◽  
Betty Fedor ◽  
Bruce A Patrick ◽  
Mark Emmerling ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells

2021 ◽  
Vol 12 (1) ◽  
pp. 301-308
Author(s):  
Yuqi Zeng ◽  
Yongkun Li ◽  
Hui Shen ◽  
Nan Lin ◽  
Jian Zhang
Keyword(s):  
Nitrosative Stress ◽  
Amyloid Β ◽  
Inflammatory Factors ◽  
Amyloid Β Protein ◽  
Neuroprotective Effects ◽  
Western Blots ◽  
Protein Levels ◽  
Cell Vitality ◽  
Β Protein ◽  
Aβ Generation

Abstract Background and purpose Alzheimer’s disease (AD) is a neurodegeneration disease. The previous work from our research group demonstrated the neuroprotective effects of tripchlorolide (T4) in AD animal models. Materials and methods Neprilysin (NEP) is known as an important physiological amyloid-β protein (Aβ) peptide-degrading enzyme in the brain due to its apparent rate-limiting function. In this study, we explored the effect of NEP on AD model N2a/APP695 cells. Western blots and enzyme-linked immunosorbent assays were performed to assess the expression of proteins, while quantitative real-time polymerase chain reaction assays were used to evaluate RNA levels. Cell vitality was detected by the MTT assay, and reactive oxygen species (ROS) levels were assessed using a ROS activity assay kit. Results We discovered that T4 was able to enhance the enzyme activity of NEP. T4 administration decreased the protein levels of the soluble amyloid precursor protein. In further experiments, we found that by using thiorphan the secretion of Aβ, oxidative stress, nitrosative stress, and inflammatory factors, which were suppressed by T4, were reversed. Due to its ability to attenuate Aβ generation and to protect neurons against the neurotoxicity of Aβ, T4 may be a potential therapy in the regulation of Aβ-related pathology in AD by affecting NEP activity. Conclusion Tripchlorolide attenuates Aβ generation by inducing NEP activity in N2a/APP695 cells.

scholarly journals Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels

2003 ◽  
Vol 60 (7) ◽  
pp. 958 ◽  
Author(s):  
Hiroaki Fukumoto ◽  
Marsha Tennis ◽  
Joseph J. Locascio ◽  
Bradley T. Hyman ◽  
John H. Growdon ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Protein Levels ◽  
Β Protein

Relationship Between Proteolytically Cleaved Gelsolin and Levels of Amyloid-β Protein in the Brains of Down Syndrome Subjects

2010 ◽  
Vol 22 (2) ◽  
pp. 609-617 ◽  
Author(s):  
Lina Ji ◽  
Ved Chauhan ◽  
Pankaj Mehta ◽  
Jerzy Wegiel ◽  
Sangita Mehta ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein
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