scholarly journals In vivo AAV-mediated expression of calbindin-D28K in rat basal forebrain cholinergic neurons

2013 ◽  
Vol 212 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Nicholas Nagykery ◽  
Ernest F. Terwilliger ◽  
Changiz Geula
Keyword(s):  
Basal Forebrain ◽  
Cholinergic Neurons ◽  
Basal Forebrain Cholinergic Neurons ◽  
Calbindin D28k

Approximation of Calcium Diffusion in Alzheimeric Cell

2019 ◽  
Vol 11 (02) ◽  
pp. 2050001 ◽  
Author(s):  
Brajesh Kumar Jha ◽  
Devanshi D. Dave
Keyword(s):  
Basal Forebrain ◽  
Calcium Binding ◽  
Cholinergic Neurons ◽  
Cytosolic Calcium ◽  
Cytoplasmic Calcium ◽  
Association Rate ◽  
Basal Forebrain Cholinergic Neurons ◽  
Calcium Diffusion ◽  
Physiological Phenomenon ◽  
Calbindin D28k

Alzheimer’s disease (AD) is the most common form of dementia prevailing worldwide. It has been found that the higher level of cytosolic calcium leads to the pathological symptoms of AD and the two cytoplasmic calcium binding buffers have their roles in sustaining this dementia. However, the area of their functioning and working is found to be different. Calmodulin is found in CA1-hippocampus neurons, whereas calbindin-D28k is found in basal forebrain cholinergic neurons. Based on this physiology, in this research paper an attempt has been made to delineate the physiological phenomenon of calcium diffusion at cytosolic level. Taking into consideration the physiology of the neuron, a two-dimensional mathematical model is used and is solved using finite element method (FEM). The appropriate initial and boundary conditions are assumed in presence of suitable diffusion coefficient of calcium and association rate of the buffer. The approximate geometries for both the neurons are taken into consideration to get a better insight about the pathology behind calcium diffusion taking place in AD. The desired results are shown graphically for Alzheimeric and non-Alzheimeric cells. Thus, the obtained results clearly show the significant impact of buffers on cytosolic calcium which affect the normal condition of the cell and maintain the cell calcium.

scholarly journals Hydrophilic cell-derived extracellular matrix as a niche to promote adhesion and differentiation of neural progenitor cells

RSC Advances ◽  
2017 ◽  
Vol 7 (72) ◽  
pp. 45587-45594 ◽  
Author(s):  
Lingyan Yang ◽  
Ziyun Jiang ◽  
Linhong Zhou ◽  
Keli Zhao ◽  
Xun Ma ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Basal Forebrain ◽  
Progenitor Cell ◽  
Neural Progenitor Cells ◽  
Cholinergic Neurons ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Basal Forebrain Cholinergic Neurons ◽  
Adhesion Performance ◽  
Excellent Adhesion

Cell-derived extracellular matrix exhibits excellent adhesion performance for neural progenitor cell anchoring and residency, resulting in promoted proliferation of the stem cells to basal forebrain cholinergic neurons.

PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats

2001 ◽  
Vol 131 (1-2) ◽  
pp. 41-45 ◽  
Author(s):  
Aki Yuhara ◽  
Chika Nishio ◽  
Yasuhiro Abiru ◽  
Hiroshi Hatanaka ◽  
Nobuyuki Takei
Keyword(s):  
Basal Forebrain ◽  
Cholinergic Neurons ◽  
Adult Rats ◽  
Neurotrophic Effect ◽  
Basal Forebrain Cholinergic Neurons
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