High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation

2012 ◽  
Vol 209 (2) ◽  
pp. 420-427 ◽  
Author(s):  
Bettina Bertram ◽  
Stefan Wiese ◽  
Alexander von Holst
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Mouse ◽  
High Efficiency ◽  
Survival Rates

scholarly journals Spatio-Temporal Recruitment Of Adult Neural Stem Cells For Transient Neurogenesis During Pregnancy

2021 ◽  
Author(s):  
Zayna Chaker ◽  
Corina Segalada ◽  
Fiona Doetsch
Keyword(s):  
Stem Cells ◽  
Olfactory Bulb ◽  
Neural Stem Cells ◽  
Adult Mouse ◽  
Life Experiences ◽  
Brain Plasticity ◽  
Perinatal Care ◽  
Adult Mouse Brain ◽  
Spatio Temporal ◽  
Care Period

Neural stem cells (NSCs) in the adult mouse brain contribute to lifelong brain plasticity. NSCs in the adult ventricular-subventricular zone (V-SVZ) are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb interneurons. Here, we show that during pregnancy multiple regionally-distinct NSCs are dynamically recruited at different times. Coordinated temporal activation of these NSC pools generates sequential waves of short-lived olfactory bulb interneuron subtypes that mature in the mother around birth and in the perinatal care period. Concomitant with neuronal addition, oligodendrocyte progenitors also transiently increase in the olfactory bulb. Thus, life experiences, such as pregnancy, can trigger transient neurogenesis and gliogenesis under tight spatial and temporal control, and may provide a novel substrate for brain plasticity in anticipation of temporary physiological demand.

Stem Cell Studies in Traumatic Brain Injury

Neurotrauma ◽  
2018 ◽  
pp. 373-386
Author(s):  
Dong Sun
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Cell Transplantation ◽  
Survival Rates ◽  
Structural Repair ◽  
Potential Strategy ◽  
Endogenous Neural Stem Cells

Traumatic brain injury (TBI) is a global public health concern, with limited treatment options available. Despite improving survival rates after TBI, there is no effective treatment to improve the neural structural repair and functional recovery of patients. Neural regeneration through neural stem cells, either by stimulating endogenous neural stem cells or by stem cell transplantation, has gained increasing attention as a potential strategy to repair and regenerate the injured brain. This chapter summarizes strategies that have been explored to enhance endogenous neural stem cells-mediated regeneration and recent developments in cell transplantation studies for post-TBI brain repair with varying types of cell sources.

scholarly journals Promotion of Cortical Neurogenesis from the Neural Stem Cells in the Adult Mouse Subcallosal Zone

Stem Cells ◽  
2016 ◽  
Vol 34 (4) ◽  
pp. 888-901 ◽  
Author(s):  
Joo Yeon Kim ◽  
Kyuhyun Choi ◽  
Mohammed R. Shaker ◽  
Ju-Hyun Lee ◽  
Boram Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Mouse ◽  
Cortical Neurogenesis

scholarly journals Stroke Increases Neural Stem Cells and Angiogenesis in the Neurogenic Niche of the Adult Mouse

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113972 ◽  
Author(s):  
Rui Lan Zhang ◽  
Michael Chopp ◽  
Cynthia Roberts ◽  
Xianshuang Liu ◽  
Min Wei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Mouse ◽  
Neurogenic Niche

scholarly journals Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain

2010 ◽  
Vol 475 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Lori B. Bennett ◽  
Jingli Cai ◽  
Grigori Enikolopov ◽  
Lorraine Iacovitti
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Adult Mouse Brain

scholarly journals Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

2014 ◽  
Vol 3 (6) ◽  
pp. 948-956 ◽  
Author(s):  
John P. Cassady ◽  
Ana C. D’Alessio ◽  
Sovan Sarkar ◽  
Vardhan S. Dani ◽  
Zi Peng Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
B Lymphocytes ◽  
Mouse Liver ◽  
Adult Mouse ◽  
Liver Cells ◽  
Direct Lineage Conversion ◽  
Adult Mouse Liver

scholarly journals PPARs Expression in Adult Mouse Neural Stem Cells: Modulation of PPARs during Astroglial Differentiaton of NSC

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-10 ◽  
Author(s):  
A. Cimini ◽  
L. Cristiano ◽  
E. Benedetti ◽  
B. D'Angelo ◽  
M. P. Cerù
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Neural Stem Cells ◽  
Osteoblast Differentiation ◽  
Adult Mouse ◽  
Cell Type ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription factors which regulate specific sets of specialized genes to allow proliferative cells to exit the cell cycle and acquire specialized functions. The main differentiation programs known to be controlled by PPARs both during development and in the adult are placental differentiation, adipogenesis, osteoblast differentiation, skin differentiation, and gut differentiation. PPARs may also be involved in the differentiation of macrophages, brain, and breast. However, their functions in this cell type and organs still awaits further elucidation. PPARs may be involved in cell proliferation and differentiation processes of neural stem cells (NSC). To this aim, in this work the expression of the three PPAR isotypes and RXRs in NSC has been investigated.

Chronic poly-drug administration damages adult mouse brain neural stem cells

2019 ◽  
Vol 1723 ◽  
pp. 146425
Author(s):  
Erica L. McGrath ◽  
Caitlin R. Schlagal ◽  
Ibdanelo Cortez ◽  
Tiffany J. Dunn ◽  
Junling Gao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Mouse Brain ◽  
Drug Administration ◽  
Adult Mouse ◽  
Adult Mouse Brain

scholarly journals Depletion of neural stem cells from the subventricular zone of adult mouse brain using cytosine b‐Arabinofuranoside

2015 ◽  
Vol 5 (11) ◽  
Author(s):  
Amir Ghanbari ◽  
Tahereh Esmaeilpour ◽  
Soghra Bahmanpour ◽  
Mohammad Ghasem Golmohammadi ◽  
Sharareh Sharififar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Mouse Brain ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Adult Mouse Brain
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