Nociceptive withdrawal reflexes evoked by uniform-temperature laser heat stimulation of large skin areas in humans

2007 ◽  
Vol 160 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Carsten Dahl Mørch ◽  
Ole Kæseler Andersen ◽  
Thomas Graven-Nielsen ◽  
Lars Arendt-Nielsen
Pain ◽  
2012 ◽  
Vol 153 (8) ◽  
pp. 1687-1694 ◽  
Author(s):  
Marcel Franz ◽  
Dorothee Spohn ◽  
Alexander Ritter ◽  
Roman Rolke ◽  
Wolfgang H.R. Miltner ◽  
...  

2017 ◽  
Vol 890 ◽  
pp. 396-400 ◽  
Author(s):  
Zabihollah Tahery ◽  
Faraidoon Rahmanzai ◽  
Shigeyuki Date

To assure the quality and required workability of mortar or concrete, various types of superplasticizers are used. There are many factors affecting the performance of superplasticizers explicitly, type and dosage of the superplasticizers, type of cement, temperature and mixing procedure, as well as the addition times of the superplasticizers. Some researchers investigated the effect of delaying the addition time of superplasticizer to mortar or concrete, but there is not enough data about the effect of external temperature on performance of superplasticizers and consequent influences on fresh properties of mortar or concrete. In this research the effect of delaying the addition time of superplasticizers and influence of external temperature, namely, heat stimulation of superplasticizers, on fluidity, fresh density and air content of fresh cement mortar was investigated. Two types of Precast and Ready-Mix of Polycarboxylic acid-based ether superplasticizers with Ordinary Portland Cement was used. Delaying the addition time of superplasticizers enhanced the fluidity, slightly decreased the fresh density and increased the air content of mortar in comparison with simultaneous addition time with both heated and non-heated Superplasticizers.


2007 ◽  
Vol 6 (4) ◽  
pp. 744-752 ◽  
Author(s):  
Andrew W. Truman ◽  
Stefan H. Millson ◽  
James M. Nuttall ◽  
Mehdi Mollapour ◽  
Chrisostomos Prodromou ◽  
...  

ABSTRACT Yeast is rendered temperature sensitive with loss of the C-terminal (CT) domain of heat shock transcription factor (Hsf1). This domain loss was found to abrogate heat stimulation of Slt2 (Mpk1), the mitogen-activated protein kinase that directs the reinforced cell integrity gene expression needed for high-temperature growth. In Hsf1 CT domain-deficient cells, Slt2 still undergoes Mkk1/2-directed dual-Thr/Tyr phosphorylation in response to the heat stimulation of cell integrity pathway signaling, but the low Hsp90 expression level suppresses any corresponding increase in Slt2 kinase activity due to Slt2 being a “client” of the Hsp90 chaperone. A non-Hsf1-directed Hsp90 overexpression restored the heat induction of Slt2 activity in these cells, as well as both Slt2-dependent (Rlm1, Swi4) and Slt2-independent (MBF) transcriptional activities. Their high-temperature growth was also rescued, not just by this Hsp90 overexpression but by osmotic stabilization, by the expression of a Slt2-independent form of the Rlm1 transcriptional regulator of cell integrity genes, and by a multicopy SLT2 gene vector. In providing the elevated Hsp90 needed for an efficient activation of Slt2, heat activation of Hsf1 indirectly facilitates (Slt2-directed) heat activation of yet another transcription factor (Rlm1). This provides an explanation as to why, in earlier transcript analysis compared to chromatin immunoprecipitation studies, many more genes of yeast displayed an Hsf1-dependent transcriptional activation by heat than bound Hsf1 directly. The levels of Hsp90 expression affecting transcription factor regulation by Hsp90 client protein kinases also provides a mechanistic model for how heat shock factor can influence the expression of several non-hsp genes in higher organisms.


2008 ◽  
Vol 119 ◽  
pp. S75
Author(s):  
Cumhur Ertekin ◽  
Şevket Yalin ◽  
Nevin Karapinar ◽  
Fikret Bademkiran ◽  
Hilmi Uysal

2017 ◽  
Vol 214 (9) ◽  
pp. 1600729 ◽  
Author(s):  
Ka My Dang ◽  
Philipp Rinklin ◽  
Jan Schnitker ◽  
Bastian Haberkorn ◽  
Kathrin Zobel ◽  
...  

1999 ◽  
Vol 110 (8) ◽  
pp. 1475-1480 ◽  
Author(s):  
Massimiliano Valeriani ◽  
Domenico Restuccia ◽  
Vincenzo Di Lazzaro ◽  
Antonio Oliviero ◽  
Paolo Profice ◽  
...  

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