Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI

2006 ◽  
Vol 156 (1-2) ◽  
pp. 17-22 ◽  
Author(s):  
Mehmet Bilgen ◽  
Warner Peng ◽  
Baraa Al-Hafez ◽  
Numa Dancause ◽  
Yong-Yue He ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Corticospinal Tract ◽  
Rat Spinal Cord ◽  
Tract Tracing ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri ◽  
Stimulation Of

Analysis of laminar activity in normal and injured rat spinal cord by manganese enhanced MRI

NeuroImage ◽  
2008 ◽  
Vol 40 (4) ◽  
pp. 1542-1551 ◽  
Author(s):  
Jean-Marie Bonny ◽  
Philippe Mailly ◽  
Jean-Pierre Renou ◽  
Didier Orsal ◽  
Abdelatif BenMoussa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Rat Spinal Cord ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

Manganese-enhanced MRI of rat spinal cord injury

2005 ◽  
Vol 23 (7) ◽  
pp. 829-832 ◽  
Author(s):  
Mehmet Bilgen ◽  
Numa Dancause ◽  
Baraa Al-Hafez ◽  
Yong-Yue He ◽  
Thomas M. Malone
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Spinal Cord ◽  
Enhanced Mri ◽  
Cord Injury ◽  
Manganese Enhanced Mri

scholarly journals Flexibility of Motor Pattern Generation Across Stimulation Conditions by the Neonatal Rat Spinal Cord

2010 ◽  
Vol 103 (3) ◽  
pp. 1580-1590 ◽  
Author(s):  
David A. Klein ◽  
Angelica Patino ◽  
Matthew C. Tresch
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Muscle Activation ◽  
Motor Pattern ◽  
Pattern Generation ◽  
Neonatal Rat ◽  
Rat Spinal Cord ◽  
Afferent Pathways ◽  
Motor Pattern Generation ◽  
Stimulation Of

Previous studies have demonstrated that “locomotor-like” rhythmic patterns can be evoked in the isolated neonatal rat spinal cord by several means, including pharmacological neuromodulation and electrical stimulation of various pathways. Recent studies have used stimulation of afferent pathways to evoke rhythmic patterns, relying on synaptic activation of interneuronal systems rather than global imposition of neuromodulatory state by pharmacological agents. We use the in vitro neonatal rat spinal cord with attached hindlimb to examine the muscle activation patterns evoked by stimulation of these different pathways and evaluate whether stimulation of these pathways all evoke the same patterns. We find that the patterns evoked by bath application of serotonin (5-HT) and N-methyl-d-aspartic acid (NMDA) consisted of alternation between hip flexors and extensors and similar alternation was observed in the patterns evoked by electrical stimulation of the cauda equina (CE) or contralateral fifth lumbar (L5) dorsal nerve root. In contrast, the knee extensor/hip flexor rectus femoris (RF) and knee flexor/hip extensor semitendinosus (ST) were activated differentially across stimulation conditions. In 5-HT/NMDA patterns, RF was active in late flexion and ST in late extension. In CE patterns, these two muscles switched places with RF typically active in late extension and ST active in flexion. In L5 patterns, ST was activated in extension and RF was silent or weakly active during flexion. There were also systematic differences in the consistency of rhythms evoked by each stimulation method: patterns evoked by electrical stimulation of CE or L5 were less consistently modulated with the rhythm when compared with 5-HT/NMDA-evoked patterns. All differences were preserved following deafferentation, demonstrating that they reflect intrinsic properties of spinal systems. These results highlight the intrinsic flexibility of motor pattern generation by spinal motor circuitry which is present from birth and provides important information to many studies examining spinal pattern generating networks.

scholarly journals Corticospinal Tract Tracing in the Marmoset with a Clinical Whole-Body 3T Scanner Using Manganese-Enhanced MRI

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138308 ◽  
Author(s):  
Boris Demain ◽  
Carole Davoust ◽  
Benjamin Plas ◽  
Faye Bolan ◽  
Kader Boulanouar ◽  
...  
Keyword(s):  
Corticospinal Tract ◽  
Whole Body ◽  
Tract Tracing ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri
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