Characterization of the oleic acid/iron oxide nanoparticle interface by magnetic resonance

2016 ◽  
Vol 415 ◽  
pp. 8-12 ◽  
Author(s):  
S. Masur ◽  
B. Zingsem ◽  
T. Marzi ◽  
R. Meckenstock ◽  
M. Farle
Keyword(s):  
Oleic Acid ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Three-Dimensional Iron Oxide Nanoparticle-Based Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Cerebral Arteriogenesis in the Mouse Neocortex

2021 ◽  
Vol 15 ◽  
Author(s):  
Till de Bortoli ◽  
Philipp Boehm-Sturm ◽  
Stefan P. Koch ◽  
Melina Nieminen-Kelhä ◽  
Lars Wessels ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Dsc Mri ◽  
Contrast Enhanced ◽  
Oxide Nanoparticle

Purpose: Subsurface blood vessels in the cerebral cortex have been identified as a bottleneck in cerebral perfusion with the potential for collateral remodeling. However, valid techniques for non-invasive, longitudinal characterization of neocortical microvessels are still lacking. In this study, we validated contrast-enhanced magnetic resonance imaging (CE-MRI) for in vivo characterization of vascular changes in a model of spontaneous collateral outgrowth following chronic cerebral hypoperfusion.Methods: C57BL/6J mice were randomly assigned to unilateral internal carotid artery occlusion or sham surgery and after 21 days, CE-MRI based on T2*-weighted imaging was performed using ultra-small superparamagnetic iron oxide nanoparticles to obtain subtraction angiographies and steady-state cerebral blood volume (ss-CBV) maps. First pass dynamic susceptibility contrast MRI (DSC-MRI) was performed for internal validation of ss-CBV. Further validation at the histological level was provided by ex vivo serial two-photon tomography (STP).Results: Qualitatively, an increase in vessel density was observed on CE-MRI subtraction angiographies following occlusion; however, a quantitative vessel tracing analysis was prone to errors in our model. Measurements of ss-CBV reliably identified an increase in cortical vasculature, validated by DSC-MRI and STP.Conclusion: Iron oxide nanoparticle-based ss-CBV serves as a robust, non-invasive imaging surrogate marker for neocortical vessels, with the potential to reduce and refine preclinical models targeting the development and outgrowth of cerebral collateralization.

Encapsulation of Superparamagnetic Iron Oxide Nanoparticles by the Supercritical Antisolvent Process

2012 ◽  
Vol 65 (1) ◽  
pp. 40 ◽  
Author(s):  
Un Teng Lam ◽  
Roshan Yoganathan ◽  
Adam G. Carr ◽  
Raffaella Mammucari ◽  
Neil R. Foster
Keyword(s):  
Iron Oxide ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Supercritical Antisolvent ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle ◽  
Toxic Organic Solvents ◽  
Superparamagnetic Properties ◽  
Product Solution

The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solvents which can be difficult to remove from the product solution. The encapsulation and characterization of SPIONs in Eudragit was done using a supercritical antisolvent system (SAS) with ethanol as the solvent and supercritical carbon dioxide (SC-CO2) as the antisolvent. Particles of diameters less than 200 nm were produced which had preserved superparamagnetic properties. An encapsulation efficiency of 70 % was achieved.

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