scholarly journals New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of P R , P L , and P RM

2016 ◽  
Vol 428 (22) ◽  
pp. 4438-4456 ◽  
Author(s):  
Dale E.A. Lewis ◽  
Gary N. Gussin ◽  
Sankar Adhya
Keyword(s):  
Bacteriophage Lambda ◽  
Dna Looping ◽  
Genetic Switch

scholarly journals A Complex Genetic Switch Involving Overlapping Divergent Promoters and DNA Looping Regulates Expression of Conjugation Genes of a Gram-positive Plasmid

PLoS Genetics ◽  
2014 ◽  
Vol 10 (10) ◽  
pp. e1004733 ◽  
Author(s):  
Gayetri Ramachandran ◽  
Praveen K. Singh ◽  
Juan Roman Luque-Ortega ◽  
Luis Yuste ◽  
Carlos Alfonso ◽  
...  
Keyword(s):  
Dna Looping ◽  
Gram Positive ◽  
Genetic Switch ◽  
Divergent Promoters

Corrigendum: DNA looping increases the range of bistability in a stochastic model of the lac genetic switch (2013 Phys. Biol. 10 026002)

2014 ◽  
Vol 11 (2) ◽  
pp. 029501
Author(s):  
Tyler M Earnest ◽  
Elijah Roberts ◽  
Michael Assaf ◽  
Karin Dahmen ◽  
Zaida Luthey-Schulten
Keyword(s):  
Stochastic Model ◽  
Dna Looping ◽  
Genetic Switch

scholarly journals Long-Range DNA Looping in the Lambda Genetic Switch

2014 ◽  
Vol 106 (2) ◽  
pp. 626a
Author(s):  
Keith Shearwin ◽  
Lun Cui ◽  
Iain Murchland ◽  
Ian B. Dodd
Keyword(s):  
Long Range ◽  
Dna Looping ◽  
Genetic Switch

scholarly journals Interaction of the Cro repressor with the lysis/lysogeny switch of the Lactobacillus casei temperate bacteriophage A2

2002 ◽  
Vol 83 (11) ◽  
pp. 2891-2895 ◽  
Author(s):  
Victor Ladero ◽  
Pilar García ◽  
Juan C. Alonso ◽  
Juan E. Suárez
Keyword(s):  
Lactobacillus Casei ◽  
Dna Looping ◽  
Lytic Cycle ◽  
Temperate Bacteriophage ◽  
Switch Region ◽  
Genetic Switch ◽  
Divergent Promoters ◽  
Phage Development ◽  
Transcriptional Switch ◽  
Late Stages

The transcriptional switch region of Lactobacillus casei temperate bacteriophage A2 contains three similar 20 bp operator subsites, O1, O2 and O3, which are interspersed between the divergent promoters P R and P L. The Cro protein binds initially to O3, which overlaps the −35 region of P L, excluding the RNA polymerase (σA-RNAP) from it. This results in the switching off of cI transcription and directs the incoming phage into the lytic cycle. At higher concentrations, Cro also binds to O1 and/or O2, which overlap P R, probably introducing a bend in the intervening DNA. This interaction induces DNA looping, which provokes the subsequent displacement of σA-RNAP from P R. Consequently, Cro abolishes the binding of σA-RNAP to the genetic switch of A2 and, presumably, its own synthesis, contributing indirectly to the entry of phage development into its late stages.

Novel tethered particle motion analysis of CI protein-mediated DNA looping in the regulation of bacteriophage lambda

2006 ◽  
Vol 18 (14) ◽  
pp. S225-S234 ◽  
Author(s):  
C Zurla ◽  
A Franzini ◽  
G Galli ◽  
D D Dunlap ◽  
D E A Lewis ◽  
...  
Keyword(s):  
Motion Analysis ◽  
Particle Motion ◽  
Bacteriophage Lambda ◽  
Dna Looping ◽  
Tethered Particle Motion
Sign in / Sign up

Export Citation Format

Share Document