Excited-State Control of Protein Activity

2011 ◽  
Vol 412 (2) ◽  
pp. 153-154 ◽  
Author(s):  
Michele Vendruscolo
Keyword(s):  
Excited State ◽  
State Control ◽  
Protein Activity

scholarly journals Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control

2021 ◽  
Author(s):  
Xiangtian Tan ◽  
Jeremy Worley ◽  
Mikko Turunen ◽  
Kelly Wong ◽  
Ester Calvo Fernandez ◽  
...  
Keyword(s):  
Regulatory Networks ◽  
Regulatory Protein ◽  
State Control ◽  
Rna Seq ◽  
Protein Activity ◽  
Genome Wide ◽  
Adenocarcinoma Cells ◽  
Reporter Assays ◽  
Gene Regulatory ◽  
Context Specific

Pooled CRISPRi-mediated silencing of >1,000 transcriptional regulators expressed in single colorectal adenocarcinoma cells, followed by single-cell RNA-seq profiling at two time points, 1D and 4D, allowed reverse engineering the underlying tumor context-specific, causal regulatory network. Furthermore, the availability of experimentally derived, highly multiplexed gene reporter assays for each regulator, as identified by this analysis, allowed accurate assessment of differential protein activity following silencing of each regulator, thus providing proof-of-concept for generating comprehensive, tissue-specific networks of transcriptional and post-translational interactions. Analysis of this causal network allowed elucidation of complex autoregulatory mechanisms that have eluded previous computational approaches and supported systematic elucidation of cooperative mechanisms, where one regulatory protein can modulate the activity of another regulatory protein, as well as transcriptional mimicry, where one regulatory protein can phenocopy others.

Structural implications on the excitation dynamics of fluorescent 3H-indolium cations

2017 ◽  
Vol 19 (19) ◽  
pp. 11904-11913 ◽  
Author(s):  
Ek Raj Thapaliya ◽  
Jaume Garcia-Amorós ◽  
Santi Nonell ◽  
Burjor Captain ◽  
Françisco M. Raymo
Keyword(s):  
Excited State ◽  
Conformational Changes ◽  
State Control ◽  
Excitation Dynamics

Conformational changes in the excited state control the excitation dynamics of fluorescent 3H-indolium cations.

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

Integration of Core-Edge Spectroscopy Methods for the Study of Polymers

1996 ◽  
Vol 54 ◽  
pp. 154-155
Author(s):  
E. G. Rightor
Keyword(s):  
Excited State ◽  
Polymer Blends ◽  
Gas Phase ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Electronic States ◽  
Core Electron ◽  
Bulk Solids ◽  
Development Application

Core edge spectroscopy methods are versatile tools for investigating a wide variety of materials. They can be used to probe the electronic states of materials in bulk solids, on surfaces, or in the gas phase. This family of methods involves promoting an inner shell (core) electron to an excited state and recording either the primary excitation or secondary decay of the excited state. The techniques are complimentary and have different strengths and limitations for studying challenging aspects of materials. The need to identify components in polymers or polymer blends at high spatial resolution has driven development, application, and integration of results from several of these methods.

Examining the degradation of environmentally-daunting per- and poly-fluoroalkyl substances from a fundamental chemical perspective

2020 ◽  
Vol 22 (31) ◽  
pp. 17659-17667 ◽  
Author(s):  
Antonio H. da S. Filho ◽  
Gabriel L. C. de Souza
Keyword(s):  
Excited State

In this work, ground and excited-state properties were used as descriptors for probing mechanisms as well as to assess potential alternatives for tackling the elimination of per- and poly-fluoroalkyl substances (PFAS).

Dynamic adjustment of emission from both singlets and triplets: the role of excited state conformation relaxation and charge transfer in phenothiazine derivates

2021 ◽  
Author(s):  
Weidong Qiu ◽  
Xinyi Cai ◽  
Mengke Li ◽  
Liangying Wang ◽  
Yanmei He ◽  
...  
Keyword(s):  
Excited State ◽  
Charge Transfer ◽  
Intramolecular Charge Transfer ◽  
Dynamic Adjustment ◽  
Twisted Intramolecular Charge Transfer

Dynamic adjustment of emission behaviours by controlling the extent of twisted intramolecular charge transfer character in excited state.

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