Simulations of the Myosin II Motor Reveal a Nucleotide-state Sensing Element that Controls the Recovery Stroke

2006 ◽  
Vol 361 (3) ◽  
pp. 604-616 ◽  
Author(s):  
Sampath Koppole ◽  
Jeremy C. Smith ◽  
Stefan Fischer
Keyword(s):  
Myosin Ii ◽  
Sensing Element ◽  
Recovery Stroke

scholarly journals Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis

2020 ◽  
Vol 124 (45) ◽  
pp. 10014-10023
Author(s):  
Anthony P. Baldo ◽  
Jil C. Tardiff ◽  
Steven D. Schwartz
Keyword(s):  
Atp Hydrolysis ◽  
Myosin Ii ◽  
Recovery Stroke

scholarly journals The Structural Coupling between ATPase Activation and Recovery Stroke in the Myosin II Motor

Structure ◽  
2007 ◽  
Vol 15 (7) ◽  
pp. 825-837 ◽  
Author(s):  
Sampath Koppole ◽  
Jeremy C. Smith ◽  
Stefan Fischer
Keyword(s):  
Myosin Ii ◽  
Structural Coupling ◽  
Recovery Stroke

Magnesium Chloride is an Effective Therapeutic Agent for Prostate Cancer

2018 ◽  
Vol 8 (1) ◽  
pp. 62 ◽  
Author(s):  
Julianna Maria Santos ◽  
Fazle Hussain
Keyword(s):  
Prostate Cancer ◽  
Magnesium Chloride ◽  
Epithelial Mesenchymal Transition ◽  
Chromatin Condensation ◽  
Myosin Ii ◽  
In Vivo Studies ◽  
Migration Speed ◽  
Mesenchymal Transition

Background: Reduced levels of magnesium can cause several diseases and increase cancer risk. Motivated by magnesium chloride’s (MgCl2) non-toxicity, physiological importance, and beneficial clinical applications, we studied its action mechanism and possible mechanical, molecular, and physiological effects in prostate cancer with different metastatic potentials.Methods: We examined the effects of MgCl2, after 24 and 48 hours, on apoptosis, cell migration, expression of epithelial mesenchymal transition (EMT) markers, and V-H+-ATPase, myosin II (NMII) and the transcription factor NF Kappa B (NFkB) expressions.Results: MgCl2 induces apoptosis, and significantly decreases migration speed in cancer cells with different metastatic potentials.  MgCl2 reduces the expression of V-H+-ATPase and myosin II that facilitates invasion and metastasis, suppresses the expression of vimentin and increases expression of E-cadherin, suggesting a role of MgCl2 in reversing the EMT. MgCl2 also significantly increases the chromatin condensation and decreases NFkB expression.Conclusions: These results suggest a promising preventive and therapeutic role of MgCl2 for prostate cancer. Further studies should explore extending MgCl2 therapy to in vivo studies and other cancer types.Keywords: Magnesium chloride, prostate cancer, migration speed, V-H+-ATPase, and EMT.

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