scholarly journals Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort

2018 ◽  
Vol 19 (2) ◽  
pp. S83-S85 ◽  
Author(s):  
Zheng Zhang ◽  
Jin-Hua Xu
Keyword(s):  
Psoriatic Arthritis ◽  
Pustular Psoriasis ◽  
Susceptibility Loci ◽  
Generalized Pustular Psoriasis

Generalized pustular psoriasis-like eruptions induced after the first use of adalimumab in the treatment of psoriatic arthritis

2011 ◽  
Vol 39 (3) ◽  
pp. 286-287 ◽  
Author(s):  
Utako KIMURA ◽  
Ayako KINOSHITA ◽  
Kunitaka HARUNA ◽  
Yuki MIZUNO ◽  
Iwao SEKIGAWA ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

Successful treatment with adalimumab in a patient with psoriatic arthritis and generalized pustular psoriasis

2012 ◽  
Vol 39 (12) ◽  
pp. 1071-1072 ◽  
Author(s):  
Utako KIMURA ◽  
Ayako KINOSHITA ◽  
Iwao SEKIGAWA ◽  
Kenji TAKAMORI ◽  
Yasushi SUGA
Keyword(s):  
Psoriatic Arthritis ◽  
Successful Treatment ◽  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis

scholarly journals Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Makoto Nagai ◽  
Yasutomo Imai ◽  
Yoshihiro Wada ◽  
Minori Kusakabe ◽  
Kiyofumi Yamanishi
Keyword(s):  
Psoriatic Arthritis ◽  
Psoriasis Vulgaris ◽  
High Serum ◽  
Serum Biomarkers ◽  
Pustular Psoriasis ◽  
Cutoff Value ◽  
Generalized Pustular Psoriasis ◽  
The Mean ◽  
Diagnosis Of Infection

Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP levels in patients with psoriatic diseases. The enrolled patients included 27 with psoriasis vulgaris (PV) (22 males, 5 females; mean age 47.7 years), 12 with psoriatic arthritis (PsA) (8 males, 4 females; mean age 51.3 years), and 15 with GPP (10 males, 5 females; mean age 63.7 years). The mean serum PCT levels in patients with PV, PsA, and GPP were 0.01 ng/mL (25th–75th percentile; 0.00–0.03), 0.013 ng/mL (0.00–0.03), and 0.12 ng/mL (0.05–0.18), respectively; the levels of PCT were higher for patients with GPP than with PV or PsA but were lower than the PCT cutoff value (0.5 ng/mL) for the diagnosis of infection. The mean serum P-SEP levels in patients with PV, PsA, and GPP were 144.9 pg/mL (25th–75th percentile; 78–181), 168.1 pg/mL (124–203), and 479.9 pg/mL (216–581), respectively. Unexpectedly, the levels of P-SEP in the patients with GPP were as high as the P-SEP cutoff value (317 to 647 pg/mL) used for the diagnosis of infection. We also found that neutrophils produced P-SEP, suggesting that the high serum P-SEP levels in patients with GPP might arise at least in part due to the P-SEP derived from neutrophils activated in GPP. Both serum PCT and P-SEP might therefore be useful as novel serum biomarkers for GPP because their levels were decreased by GPP treatments. However, the measurement of PCT might be more useful than the measurement of P-SEP for discriminating between GPP and sepsis.

Generalized pustular psoriasis

1979 ◽  
Vol 115 (10) ◽  
pp. 1215-1216 ◽  
Author(s):  
F. R. Murphy
Keyword(s):  
Pustular Psoriasis ◽  
Generalized Pustular Psoriasis
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