scholarly journals Partially purified lead molecules from Dodonaea viscosa and their antimicrobial inhibitory efficacy against infectious human pathogens

2021 ◽  
Author(s):  
V. Thamil Priya ◽  
Balasubramanian N. ◽  
Shanmugaiah V. ◽  
Sathishkumar P. ◽  
Kannan N.D. ◽  
...  
Keyword(s):  
Human Pathogens ◽  
Dodonaea Viscosa

Plasminogen Activation by Invasive Human Pathogens

1997 ◽  
Vol 77 (01) ◽  
pp. 001-010 ◽  
Author(s):  
Michael D P Boyle ◽  
Richard Lottenberg
Keyword(s):  
Plasminogen Activators ◽  
Plasminogen Activation ◽  
Potential Importance ◽  
Human Pathogens

SummaryIn this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.

Multitemporal distribution analysis of Dodonaea viscosa (L.) Jacq. by remote sensing in Durango, Mexico

2020 ◽  
Vol 13 (8) ◽  
Author(s):  
Marco, A. Márquez-Linares ◽  
Jonathan G. Escobar--Flores ◽  
Sarahi Sandoval- Espinosa ◽  
Gustavo Pérez-Verdín
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Design Methodology ◽  
Supervised Classification ◽  
Satellite Images ◽  
Ground Cover ◽  
Distribution Analysis ◽  
Dodonaea Viscosa ◽  
Artificial Neural ◽  
Landsat Satellite

Objective: to determine the distribution of D. viscosa in the vicinity of the Guadalupe Victoria Dam in Durango, Mexico, for the years 1990, 2010 and 2017.Design/Methodology/Approach: Landsat satellite images were processed in order to carry out supervised classifications using an artificial neural network. Images from the years 1990, 2010 and 2017 were used to estimate ground cover of D. viscosa, pastures, crops, shrubs, and oak forest. This data was used to calculate the expansion of D. viscosa in the study area.Results/Study Limitations/Implications: the supervised classification with the artificial neural network was optimal after 400 iterations, obtaining the best overall precision of 84.5 % for 2017. This contrasted with the year 1990, when overall accuracy was low at 45 % due to less training sites (fewer than 100) recorded for each of the land cover classes.Findings/Conclusions: in 1990, D. viscosa was found on only five hectares, while by 2017 it had increased to 147 hectares. If the disturbance caused by overgrazing continues, and based on the distribution of D. viscosa, it is likely that in a few years it will have the ability to invade half the study area, occupying agricultural, forested, and shrub areas

The gut microbiota resistome provides development of drug resistance in causative agents of human infectious diseases

2017 ◽  
pp. 20-32 ◽  
Author(s):  
Е.Н. Ильина ◽  
Е.И. Олехнович ◽  
А.В. Павленко
Keyword(s):  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Integrated Approach ◽  
Modern Medicine ◽  
Pathogenic Microorganisms ◽  
Human Pathogens ◽  
Potential Source ◽  
Causative Agents ◽  
Bacterial Genes

С течением времени подходы к изучению резистентности к антибиотикам трансформировались от сосредоточения на выделенных в виде чистой культуры патогенных микроорганизмах к исследованию резистентности на уровне микробных сообществ, составляющих биотопы человека и окружающей среды. По мере того, как продвигается изучение устойчивости к антибиотикам, возникает необходимость использования комплексного подхода для улучшения информирования мирового сообщества о наблюдаемых тенденциях в этой области. Все более очевидным становится то, что, хотя не все гены резистентности могут географически и филогенетически распространяться, угроза, которую они представляют, действительно серьезная и требует комплексных междисциплинарных исследований. В настоящее время резистентность к антибиотикам среди патогенов человека стала основной угрозой в современной медицине, и существует значительный интерес к определению ниши, в которых бактерии могут получить гены антибиотикорезистентности, и механизмов их передачи. В данном обзоре мы рассматриваем проблемы, возникшие на фоне широкого использования человечеством антибактериальных препаратов, в свете формирования микрофлорой кишечника резервуара генов резистентности. Over the time, studies of antibiotic resistance have transformed from focusing on pathogenic microorganisms isolated as a pure culture to analysis of resistance at the level of microbial communities that constitute human and environmental biotopes. Advancing studies of antibiotic resistance require an integrated approach to enhance availability of information about observed tendencies in this field to the global community. It becomes increasingly obvious that, even though not all resistance genes can geographically and phylogenetically spread, the threat they pose is indeed serious and requires complex interdisciplinary research. Currently, the antibiotic resistance of human pathogens has become a challenge to modern medicine, which is now focusing on determining a potential source for bacterial genes of drug resistance and mechanisms for the gene transmission. In this review, we discussed problems generated by the widespread use of antibacterial drugs in the light of forming a reservoir of resistance genes by gut microflora.

Deep-Amplicon Sequencing(DAS) to evidence the presesence of human pathogens in drinking water

2020 ◽  
Author(s):  
Laura Moreno-Mesonero ◽  
Jorge García Hernández ◽  
Yolanda Moreno ◽  
PATRICIA SOLER
Keyword(s):  
Drinking Water ◽  
Amplicon Sequencing ◽  
Human Pathogens

scholarly journals Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation

2020 ◽  
Author(s):  
Kaat Schroven ◽  
Abram Aertsen ◽  
Rob Lavigne
Keyword(s):  
Small Molecules ◽  
Bacterial Infections ◽  
Bacterial Virulence ◽  
Arms Race ◽  
Control Mechanisms ◽  
Human Pathogens ◽  
Vaccine Candidates ◽  
Cargo Proteins ◽  
Genes Encoding ◽  
Mutualistic Relationship

ABSTRACT Bacteria-infecting viruses (phages) and their hosts maintain an ancient and complex relationship. Bacterial predation by lytic phages drives an ongoing phage-host arms race, whereas temperate phages initiate mutualistic relationships with their hosts upon lysogenization as prophages. In human pathogens, these prophages impact bacterial virulence in distinct ways: by secretion of phage-encoded toxins, modulation of the bacterial envelope, mediation of bacterial infectivity and the control of bacterial cell regulation. This review builds the argument that virulence-influencing prophages hold extensive, unexplored potential for biotechnology. More specifically, it highlights the development potential of novel therapies against infectious diseases, to address the current antibiotic resistance crisis. First, designer bacteriophages may serve to deliver genes encoding cargo proteins which repress bacterial virulence. Secondly, one may develop small molecules mimicking phage-derived proteins targeting central regulators of bacterial virulence. Thirdly, bacteria equipped with phage-derived synthetic circuits which modulate key virulence factors could serve as vaccine candidates to prevent bacterial infections. The development and exploitation of such antibacterial strategies will depend on the discovery of other prophage-derived, virulence control mechanisms and, more generally, on the dissection of the mutualistic relationship between temperate phages and bacteria, as well as on continuing developments in the synthetic biology field.

Sign in / Sign up

Export Citation Format

Share Document