scholarly journals Impact of antibiotic de-escalation on hospitalized patients with urinary tract infections: A retrospective cohort single center study

2020 ◽  
Vol 13 (7) ◽  
pp. 985-990 ◽  
Author(s):  
Hanan Alshareef ◽  
Wafa Alfahad ◽  
Abeer Albaadani ◽  
Huda Alyazid ◽  
Ruba Bin Talib
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Retrospective Cohort ◽  
Hospitalized Patients ◽  
Single Center ◽  
Single Center Study ◽  
Tract Infections ◽  
Center Study

scholarly journals Outcome and clinical course of EHEC O104 infection in hospitalized patients: A prospective single center study

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0191544
Author(s):  
J. P. Albersmeier ◽  
J. P. Bremer ◽  
W. Dammermann ◽  
S. Lüth ◽  
F. Hagenmüller ◽  
...  
Keyword(s):  
Clinical Course ◽  
Hospitalized Patients ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

scholarly journals Fosfomycin versus Ertapenem for Outpatient Treatment of Complicated Urinary Tract Infections: A Multicenter, Retrospective Cohort Study

2021 ◽  
Author(s):  
Noah Wald-Dickler ◽  
Todd C Lee ◽  
Soodtida Tangpraphaphorn ◽  
Susan M Butler-Wu ◽  
Nina Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Urinary Tract ◽  
Los Angeles ◽  
Urinary Tract Infections ◽  
Retrospective Cohort Study ◽  
Outpatient Treatment ◽  
Retrospective Cohort ◽  
Clinical Success ◽  
Public Hospitals ◽  
Tract Infections

Abstract Objectives We sought to determine the comparative efficacy of fosfomycin vs. ertapenem for outpatient treatment of complicated urinary tract infections (cUTI). Methods We conducted a multi-centered, retrospective cohort study involving patients with cUTI treated with outpatient oral fosfomycin vs. intravenous ertapenem at three public hospitals in Los Angeles County between January 2018 and September 2020. The primary outcome was resolution of clinical symptoms 30 days after diagnosis. Results We identified 322 patients with cUTI treated with fosfomycin (n = 110) or ertapenem (n = 212) meeting study criteria. Study arms had similar demographics, although patients treated with ertapenem more frequently had pyelonephritis or bacteremia while fosfomycin-treated patients had more retained catheters, nephrolithiasis, or urinary obstruction. Most infections were due to extended-spectrum β-lactamase-producing E. coli and Klebsiella pneumoniae; 80-90% of which were resistant to other oral options. Adjusted odds ratios for clinical success at 30 days, clinical success at last follow up, and relapse were 1.21 (0.68 to 2.16), 0.84 (0.46 to 1.52), and 0.94 (0.52 to 1.70), for fosfomycin vs. ertapenem, respectively. Patients treated with fosfomycin had significant reductions in length of hospital stay and length of antimicrobial therapy, and fewer adverse events (1 vs. 10). Fosfomycin outcomes were similar irrespective of duration of lead-in IV therapy or fosfomycin dosing interval (daily, every other day, every third day). Conclusion These results would support the conduct of a randomized controlled trial to verify efficacy. In the meantime, they suggest fosfomycin may be a reasonable stepdown from IV antibiotics for cUTI.

Sign in / Sign up

Export Citation Format

Share Document