scholarly journals Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings

2020 ◽  
Vol 13 (2) ◽  
pp. 326-327
Author(s):  
A Ayfan ◽  
N Ertl ◽  
D Whiley ◽  
D Paterson ◽  
C Heney ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Molecular Detection ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Low Resource Settings ◽  
Low Resource

Distance-based microfluidic quantitative detection methods for point-of-care testing

Lab on a Chip ◽  
2016 ◽  
Vol 16 (7) ◽  
pp. 1139-1151 ◽  
Author(s):  
Tian Tian ◽  
Jiuxing Li ◽  
Yanling Song ◽  
Leiji Zhou ◽  
Zhi Zhu ◽  
...  
Keyword(s):  
Real Time ◽  
Point Of Care ◽  
Detection Methods ◽  
Quantitative Detection ◽  
Point Of Care Testing ◽  
Low Resource Settings ◽  
Low Resource ◽  
Time Readout

Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings.

scholarly journals Point-of-care testing for sexually transmitted infections in low-resource settings

2021 ◽  
Author(s):  
Silver Vargas ◽  
Gino Calvo ◽  
Jazmin Qquellon ◽  
Francesca Vasquez ◽  
Karel Blondel ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Low Resource Settings ◽  
Sexually Transmitted ◽  
Low Resource

scholarly journals The good and the bad: using C reactive protein to distinguish bacterial from non-bacterial infection among febrile patients in low-resource settings

2020 ◽  
Vol 5 (5) ◽  
pp. e002396 ◽  
Author(s):  
Camille Escadafal ◽  
Sandra Incardona ◽  
B Leticia Fernandez-Carballo ◽  
Sabine Dittrich
Keyword(s):  
Antimicrobial Resistance ◽  
Low Income ◽  
Bacterial Infections ◽  
Laboratory Diagnostics ◽  
Antibiotic Prescribing ◽  
Health Coverage ◽  
C Reactive Protein ◽  
Low Resource Settings ◽  
Low Resource ◽  
Reactive Protein

C reactive protein (CRP), a marker for the presence of an inflammatory process, is the most extensively studied marker for distinguishing bacterial from non-bacterial infections in febrile patients. A point-of-care test for bacterial infections would be of particular use in low-resource settings where other laboratory diagnostics are not always available, antimicrobial resistance rates are high and bacterial infections such as pneumonia are a leading cause of death. This document summarises evidence on CRP testing for bacterial infections in low-income and middle-income countries (LMICs). With a push for universal health coverage and prevention of antimicrobial resistance, it is important to understand if CRP might be able to do the job. The use of CRP polarised the global health community and the aim of this document is to summarise the ‘good and the bad’ of CRP in multiple settings in LMICs. In brief, the literature that was reviewed suggests that CRP testing may be beneficial in low-resource settings to improve rational antibiotic use for febrile patients, but the positive predictive value is insufficient to allow it to be used alone as a single tool. CRP testing may be best used as part of a panel of diagnostic tests and algorithms. Further studies in low-resource settings, particularly with regard to impact on antibiotic prescribing and cost-effectiveness of CRP testing, are warranted.

scholarly journals Detecting tuberculosis: rapid tools but slow progress

2019 ◽  
Vol 9 (3) ◽  
pp. 80-83
Author(s):  
K. England ◽  
T. Masini ◽  
E. Fajardo
Keyword(s):  
Point Of Care ◽  
Scale Up ◽  
Critical Issue ◽  
World Health ◽  
High Turnover ◽  
Low Resource Settings ◽  
Laboratory Staff ◽  
Low Resource ◽  
Point Of Care Test ◽  
Health Organization

The World Health Organization (WHO) currently recommends Xpert® MTB/RIF as the initial test for all people with presumptive tuberculosis (TB). A number of challenges have been reported, however, in using this technology, particularly in low-resource settings. Here we examine these challenges, and provide our perspective of the barriers to Xpert scale-up as assessed through a survey in 16 TB burden countries in which the Médecins Sans Frontières is present. We observed that the key barriers to scale-up include a lack of policy adoption and implementation of WHO recommendations for the use of Xpert, resulting from high costs, poor sensitisation of clinical staff and a high turnover of trained laboratory staff; insufficient service and maintenance provision provided by the manufacturer; and inadequate resources for sustainability and expansion. Funding is a critical issue as countries begin to transition out of support from the Global Fund. While it is clear that there is still an urgent need for research into and development of a rapid, affordable point-of-care test for TB that is truly adapted for use in low-resource settings, countries in the meantime need to develop functional and sustainable Xpert networks in order to close the existing diagnostic gap.

scholarly journals A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3898-3903 ◽  
Author(s):  
Maowei Dou ◽  
Juan Lopez ◽  
Misael Rios ◽  
Oscar Garcia ◽  
Chuan Xiao ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Power Supplies ◽  
Low Resource Settings ◽  
Low Resource ◽  
External Power

A low-cost b̲a̲ttery-powered s̲pectrophotometric s̲ystem (BASS) was developed for high-sensitivity point-of-care analysis in low-resource settings on a microfluidic chip without relying on external power supplies.

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