A prospective study of isolated human hepatocyte function following liver resection for colorectal liver metastases: The effects of prior exposure to chemotherapy

2006 ◽  
Vol 45 (2) ◽  
pp. 263-270 ◽  
Author(s):  
James C. Hewes ◽  
Darren Riddy ◽  
Richard W. Morris ◽  
Amanda J. Woodrooffe ◽  
Brian R. Davidson ◽  
...  
Keyword(s):  
Liver Resection ◽  
Prospective Study ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Human Hepatocyte ◽  
Prior Exposure ◽  
A Prospective Study

Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: A prospective study

2002 ◽  
Vol 9 (5) ◽  
pp. 430-438 ◽  
Author(s):  
Daniel Jaeck ◽  
Hiroshi Nakano ◽  
Philippe Bachellier ◽  
Keiichiro Inoue ◽  
Jean-Christophe Weber ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prospective Study ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Lymph Node Involvement ◽  
Hepatic Pedicle ◽  
Node Involvement ◽  
A Prospective Study

Comparison Between Local Ablative Therapy and Chemotherapy for Non-Resectable Colorectal Liver Metastases: A Prospective Study

2006 ◽  
Vol 14 (3) ◽  
pp. 1161-1169 ◽  
Author(s):  
Theo J. M. Ruers ◽  
Joris J. Joosten ◽  
Bastiaan Wiering ◽  
Barbara S. Langenhoff ◽  
Heleen M. Dekker ◽  
...  
Keyword(s):  
Prospective Study ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Ablative Therapy ◽  
Local Ablative Therapy ◽  
A Prospective Study

904 Radioembolisation for colorectal liver metastases after ablation: A prospective study - The RELAPSE study

2015 ◽  
Vol 51 ◽  
pp. S140-S141
Author(s):  
M. Samim ◽  
W. Prevoo ◽  
M. Van den Bosch ◽  
I. Borel Rinkes ◽  
T. Ruers ◽  
...  
Keyword(s):  
Prospective Study ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
A Prospective Study

Radiofrequency ablation of colorectal liver metastases

2019 ◽  
Vol 98 (10) ◽  
Keyword(s):  
Radiofrequency Ablation ◽  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Survival Rates ◽  
Postoperative Mortality ◽  
Disease Free Survival ◽  
Female Ratio ◽  
Liver Resections ◽  
Multi Stage

Introduction: Radical liver resection is the only method for the treatment of patients with colorectal liver metastases (CLM); however, only 20–30% of patients with CLMs can be radically treated. Radiofrequency ablation (RFA) is one of the possible methods of palliative treatment in such patients. Methods: RFA was performed in 381 patients with CLMs between 01 Jan 2001 and 31 Dec 2018. The mean age of the patients was 65.2±8.7 years. The male to female ratio was 2:1. Open laparotomy was done in 238 (62.5%) patients and the CT-navigated transcutaneous approach was used in 143 (37.5%) patients. CLMs <5 cm (usually <3 cm) in diameter were the indication for RFA. We used RFA as the only method in 334 (87.6%) patients; RFA in combination with resection was used in 36 (9.4%), and with multi-stage resection in 11 (3%) patients. We performed RFA in a solitary CLM in 170 (44.6%) patients, and in 2−5 CLMs in 211 (55.6%) patients. We performed computed tomography in each patient 48 hours after procedure. Results: The 30-day postoperative mortality was zero. Complications were present in 4.8% of transcutaneous and in 14.2% of open procedures, respectively, in the 30-day postoperative period. One-, 3-, 5- and 10-year overall survival rates were 94.8, 66.8, 43.9 and 16.6%, respectively, in patients undergoing RFA, and 90.6, 69.1, 52.8 and 39.2%, respectively, in patients with liver resections. Disease free survival was 63.2, 30.1, 18.4 and 13.1%, respectively, in the same patients after RFA, and 71.1, 33.3, 22.8 and 15.5%, respectively, after liver resections. Conclusion: RFA is a palliative thermal ablation method, which is one of therapeutic options in patients with radically non-resectable CLMs. RFA is useful especially in a non-resectable, or resectable (but for the price of large liver resection) solitary CLM <3 cm in diameter and in CLM relapses. RFA is also part of multi-stage liver procedures.

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