scholarly journals Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson's disease model mice

2021 ◽  
Vol 85 ◽  
pp. 104635
Author(s):  
Lei Wang ◽  
Shengyu Li ◽  
Yu Jiang ◽  
Zijian Zhao ◽  
Yunjiao Shen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lactobacillus Plantarum ◽  
Neuroprotective Effect ◽  
Disease Model

scholarly journals Neuroprotective effect and mechanism of baicalin on Parkinson’s disease model induced by 6-OHDA

2020 ◽  
Vol Volume 15 ◽  
pp. 3615-3625 ◽  
Author(s):  
Li Tu ◽  
Zhuo-Yu Wu ◽  
Xiu-Lin Yang ◽  
Qian Zhang ◽  
Ran Gu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Disease Model

Synphilin-1 has neuroprotective effect on Parkinson’s disease-model cells by inhibiting apoptosis

2017 ◽  
Vol 381 ◽  
pp. 736-737
Author(s):  
T. Shishido ◽  
Y. Nagano ◽  
M. Araki ◽  
T. Takahashi ◽  
M. Matsumoto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Disease Model

scholarly journals Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Juan Lu ◽  
Xuelei Liu ◽  
Ye Tian ◽  
Hang Li ◽  
Zhenxing Ren ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Disease Model ◽  
Protective Mechanism ◽  
Neural Cells ◽  
Ferritin Heavy Chain ◽  
Functional Pathway ◽  
6 Hydroxydopamine ◽  
The Right

The objective of this study was to explore the neuroprotective effect of moxibustion on rats with Parkinson’s disease (PD) and its mechanism. A Parkinson’s disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (SN) and ventral tegmental area. The rats received moxibustion at the Baihui (GV20) and Sishencong (EX-HN1) acupoints for 20 minutes, six times a week, for 6 weeks. The right SN tissue was histologically and immunohistochemically examined. Differentially expressed genes (DEGs) were identified through RNA sequencing. In addition, the levels of tyrosine hydroxylase (TH), glutathione peroxidase 4 (GPX4), and ferritin heavy chain 1 (FTH1) in SN were measured. In comparison to the model group, the moxibustion group showed a significantly greater TH immunoreactivity and a higher behavioural score. In particular, moxibustion led to an increase in the number and morphological stability of SN neural cells. The functional pathway analysis showed that DEGs are closely related to the ferroptosis pathway. GPX4 and FTH1 in the SN were significantly overexpressed in the moxibustion-treated rats with PD. Moxibustion can effectively reduce the death of SN neurons, decrease the occurrence of ferroptosis, and increase the TH activity to protect the neurons in rats with PD. The protective mechanism may be associated with suppression of the ferroptosis.

Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model

2018 ◽  
Vol 14 (4) ◽  
pp. 1123-1136 ◽  
Author(s):  
Kaikai Hu ◽  
Xiaohui Chen ◽  
Wuya Chen ◽  
Lingkun Zhang ◽  
Jian Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gold Nanoparticles ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Disease Model

Neuroprotective effect of NXP031 in the MPTP-induced Parkinson's disease model

2021 ◽  
Vol 740 ◽  
pp. 135425
Author(s):  
Min Kyung Song ◽  
Joo Hee Lee ◽  
Jinil Kim ◽  
Ji Hyun Kim ◽  
Soonhye Hwang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuroprotective Effect ◽  
Disease Model

Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase

2004 ◽  
Vol 18 (3) ◽  
pp. 589-591 ◽  
Author(s):  
Wei Zhang ◽  
Tongguang Wang ◽  
Liya Qin ◽  
Hui‐Ming Gao ◽  
Belinda Wilson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nadph Oxidase ◽  
Neuroprotective Effect ◽  
Disease Model

Neuroprotective effect of crocin on substantia nigra in MPTP-induced Parkinson’s disease model of mice

2018 ◽  
Vol 94 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Parisa Haeri ◽  
Abbas Mohammadipour ◽  
Zahra Heidari ◽  
Alireza Ebrahimzadeh-bideskan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Neuroprotective Effect ◽  
Disease Model
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