scholarly journals Effect of Lactobacillus plantarum KFY02 isolated from naturally fermented yogurt on the weight loss in mice with high-fat diet-induced obesity via PPAR-α/γ signaling pathway

2020 ◽  
Vol 75 ◽  
pp. 104264
Author(s):  
Jianfei Mu ◽  
Jing Zhang ◽  
Xianrong Zhou ◽  
Zsolt Zalan ◽  
Ferenc Hegyi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Signaling Pathway ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2341
Author(s):  
Conner W. Wallace ◽  
Nari S. Beatty ◽  
Sarah A. Hutcherson ◽  
Heather A. Emmons ◽  
Madison C. Loudermilt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Nucleus Accumbens ◽  
High Fat Diet ◽  
Elevated Plus Maze ◽  
High Fat ◽  
Food Cravings ◽  
Fast Scan Cyclic Voltammetry ◽  
Diet Induced Obesity ◽  
Plus Maze ◽  
Weight Loss Interventions

Diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (NAc), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. Activation of κ-opioid receptors (KORs) reduces synaptic dopamine, but contribution of KORs to lower dopamine tone after dietary changes is unknown. Therefore, the purpose of this study was to determine the function of KORs in C57BL/6 mice that consumed a 60% high-fat diet (HFD) for six weeks followed by replacement of HFD with a control 10% fat diet for one day or one week. HFD replacement induced voluntary caloric restriction and weight loss. However, fast-scan cyclic voltammetry revealed no differences in baseline dopamine parameters, whereas sex effects were revealed during KOR stimulation. NAc core dopamine release was reduced by KOR agonism after one day of HFD replacement in females but after one week of HFD replacement in males. Further, elevated plus-maze testing revealed no diet effects during HFD replacement on overt anxiety. These results suggest that KORs reduce NAc dopamine tone and increase food-related anxiety during dietary weight loss interventions that could subsequently promote palatable food cravings and inhibit weight loss.

Lactobacillus plantarum KFY04 prevents obesity in mice through the PPAR pathway and alleviates oxidative damage and inflammation

2020 ◽  
Vol 11 (6) ◽  
pp. 5460-5472
Author(s):  
Xingyao Long ◽  
Xiaofei Zeng ◽  
Fang Tan ◽  
Ruokun Yi ◽  
Yanni Pan ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Oxidative Damage ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
Adipocyte Size ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Ppar Pathway

Lactobacillus plantarum KFY04 can significantly inhibited the increase of adipocytes and decrease the adipocyte size in adipose tissue. LP-KFY04 can be used to mitigate high-fat-diet-induced obesity in mice.

scholarly journals Mass spectrometry imaging of mice brain lipid profile changes over time under high fat diet

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gianluca Sighinolfi ◽  
Samantha Clark ◽  
Landry Blanc ◽  
Daniela Cota ◽  
Boutayna Rhourri-Frih
Keyword(s):  
Mass Spectrometry ◽  
Weight Loss ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Overweight And Obesity ◽  
Mass Spectrometry Analysis ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Imaging Approach ◽  
The Brain

AbstractOverweight and obesity have been shown to significantly affect brain structures and size. Obesity has been associated with cerebral atrophy, alteration of brain functions, including cognitive impairement, and psychiatric diseases such as depression. Given the importance of lipids in the structure of the brain, here, by using 47 mice fed a high fat diet (HFD) with 60% calories from fat (40% saturated fatty acids) and 20% calories from carbohydrates and age-matched control animals on a normal chow diet, we examined the effects of HFD and diet-induced obesity on the brain lipidome. Using a targeted liquid chromatography mass spectrometry analysis and a non-targeted mass spectrometry MALDI imaging approach, we show that the relative concentration of most lipids, in particular brain phospholipids, is modified by diet-induced obesity (+ 40%of body weight). Use of a non-targeted MALDI-MS imaging approach further allowed define cerebral regions of interest (ROI) involved in eating behavior and changes in their lipid profile. Principal component analysis (PCA) of the obese/chow lipidome revealed persistence of some of the changes in the brain lipidome of obese animals even after their switch to chow feeding and associated weight loss. Altogether, these data reveal that HFD feeding rapidly modifies the murine brain lipidome. Some of these HFD-induced changes persist even after weight loss, implying that some brain sequelae caused by diet-induced obesity are irreversible.

scholarly journals Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Lisa R Beutler ◽  
Timothy V Corpuz ◽  
Jamie S Ahn ◽  
Seher Kosar ◽  
Weimin Song ◽  
...  
Keyword(s):  
Weight Loss ◽  
Dietary Fat ◽  
High Fat Diet ◽  
Neural Circuits ◽  
Gastrointestinal Hormones ◽  
Food Cues ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development of diet-induced obesity in mice. We show that high-fat diet attenuates the response of AgRP neurons to an array of nutritionally-relevant stimuli including food cues, intragastric nutrients, cholecystokinin and ghrelin. These alterations are specific to dietary fat but not carbohydrate or protein. Subsequent weight loss restores the responsiveness of AgRP neurons to exterosensory cues but fails to rescue their sensitivity to gastrointestinal hormones or nutrients. These findings reveal that obesity triggers broad dysregulation of hypothalamic hunger neurons that is incompletely reversed by weight loss and may contribute to the difficulty of maintaining a reduced weight.

Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via the AMPKα-LXRα/SREBP-1c pathway in high-fat diet-induced obese mice

2019 ◽  
Vol 10 (11) ◽  
pp. 7489-7497 ◽  
Author(s):  
Meng Xu ◽  
Licong Yang ◽  
Yanping Zhu ◽  
Mingfu Liao ◽  
Lulu Chu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Chlorogenic Acid ◽  
Signaling Pathway ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Diet Induced Obesity

The combination of CGA and caffeine exhibits anti-obesity effects and regulates lipid metabolism via the AMPKα-LXRα/SREBP-1c signaling pathway in mice with high-fat diet-induced obesity.

Regulating effect of Lactobacillus plantarum CQPC03 on lipid metabolism in high‐fat diet‐induced obesity in mice

2020 ◽  
Vol 44 (11) ◽  
Author(s):  
Yi Gan ◽  
Hong Chen ◽  
Xian‐Rong Zhou ◽  
Ling‐Ling Chu ◽  
Wan‐Ting Ran ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Lactobacillus Plantarum ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice

scholarly journals Effect of high-fat diet-induced obesity on the Akt/FoxO/Smad signaling pathway and the follicular development of the mouse ovary

2016 ◽  
Vol 14 (4) ◽  
pp. 3894-3900 ◽  
Author(s):  
Yanqing Wu ◽  
Zhenghong Zhang ◽  
Xinghui Liao ◽  
Lingbin Qi ◽  
Yiping Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
High Fat Diet ◽  
Follicular Development ◽  
High Fat ◽  
Mouse Ovary ◽  
Smad Signaling ◽  
Diet Induced Obesity ◽  
Smad Signaling Pathway
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