scholarly journals Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model

2020 ◽  
Vol 73 ◽  
pp. 104142
Author(s):  
Anqi Wang ◽  
Changhao Xiao ◽  
Jianxian Zheng ◽  
Chuansong Ye ◽  
Zhen Dai ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Ganoderma Lucidum ◽  
In Vivo Model

scholarly journals A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment (P14-021-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Amelie Nkodo
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Ganoderma Lucidum ◽  
Dietary Supplementation ◽  
Cognitive Outcomes ◽  
In Vivo Studies ◽  
Hericium Erinaceus ◽  
Ophiocordyceps Sinensis ◽  
Positive Results

Abstract Objectives A systematic review was undertaken of the evidence on the use of Hericium erinaceus (Reishi), Ganoderma lucidum (Lion's Mane), Ophiocordyceps sinensis (Cordyceps) and Cordyceps militaris (Cordyceps), dietary supplementation on cognitive impairment outcomes. Methods Relevant articles were identified in major databases (PubMed, Embase, Web of Science, and SCOPUS). Key search words were Hericium erinaceus, Ganoderma lucidum, Ophiocordyceps sinensis, Lion's mane, Reishi, Cordyceps, cognitive, memory, dementia, Alzheimer's. Included studies were peer-reviewed in-vivo articles published in English before January 2019, with cognitive outcomes. Results Twenty-five (25) of 194 studies met the inclusion criteria: eight (8) studies on lion's mane mushroom, seven (7) studies on reishi mushroom and ten (10) studies on cordyceps mushroom. Three (3) randomized-controlled trials were included in this review. Studies varied by animals used, preparation of supplement, dosage and duration of supplementation, and cognitive outcomes. Twenty-two (22) animal studies found positive results (P < 0.05) on at least one of the doses tested for at least one cognitive impairment outcome. Of the human trials, two (2) studies found positive results (P < 0.05) on at least one of the cognitive assessments. Conclusions Despite heterogeneous study design, the results of this review suggest that dietary supplementation with lion's mane, reishi and cordyceps mushrooms may have a beneficial effect on cognitive impairment. Further clinical research studies are needed to demonstrate the potential medicinal benefits of dietary mushroom supplementation in humans with cognitive impairments. Funding Sources No external funding.

Establishment of an in vivo model for KCNJ5 dependent hyperaldosteronism

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
U Lichtenauer ◽  
PL Schmid ◽  
A Oßwald ◽  
I Renner-Müller ◽  
M Reincke ◽  
...  
Keyword(s):  
In Vivo Model

An in vivo Model for the Assessment of Acute Fibrinolytic Capacity of the Endothelium

1997 ◽  
Vol 78 (04) ◽  
pp. 1242-1248 ◽  
Author(s):  
David E Newby ◽  
Robert A Wright ◽  
Christopher A Ludlam ◽  
Keith A A Fox ◽  
Nicholas A Boon ◽  
...  
Keyword(s):  
Blood Flow ◽  
Substance P ◽  
Sodium Nitroprusside ◽  
Plasma Concentrations ◽  
In Vivo Model ◽  
Forearm Circulation ◽  
Von Willebrand ◽  
Local Release ◽  
Willebrand Factor

SummaryThe effects on blood flow and plasma fibrinolytic and coagulation parameters of intraarterial substance P, an endothelium dependent vasodilator, and sodium nitroprusside, a control endothelium independent vasodilator, were studied in the human forearm circulation. At subsystemic locally active doses, both substance P (2-8 pmol/min) and sodium nitroprusside (2-8 μg/min) caused dose-dependent vasodilatation (p <0.001 for both) without affecting plasma concentrations of PAI-1, von Willebrand factor antigen or factor VIII:C activity. Substance P caused local increases in t-PA antigen and activity (p <0.001) in the infused arm while sodium nitroprusside did not. At higher doses, substance P increased blood flow and t-PA concentrations in the noninfused arm. We conclude that brief, locally active and subsystemic infusions of intraarterial substance P cause a rapid and substantial local release of t-PA which appear to act via a flow and nitric oxide independent mechanism. This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely.

Closure of Fetoscopic Access Sites with Amniotic Extracellular Matrix Scaffolds in an In Vivo Model

2006 ◽  
Vol 66 (S 01) ◽  
Author(s):  
N Ochsenbein-Kölble ◽  
J Jani ◽  
G Verbist ◽  
L Lewi ◽  
K Marquardt ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
In Vivo Model ◽  
Extracellular Matrix Scaffolds
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