Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

2016 ◽  
Vol 25 ◽  
pp. 186-196 ◽  
Author(s):  
Mengmei Ma ◽  
Taihua Mu
2015 ◽  
Vol 169 ◽  
pp. 269-274 ◽  
Author(s):  
Tabusi Manaer ◽  
Lan Yu ◽  
Yi Zhang ◽  
Xue-Jun Xiao ◽  
Xin-Hua Nabi

2012 ◽  
Vol 132 (1) ◽  
pp. 186-193 ◽  
Author(s):  
V.P. Veerapur ◽  
K.R. Prabhakar ◽  
B.S. Thippeswamy ◽  
Punit Bansal ◽  
K.K. Srinivasan ◽  
...  

2013 ◽  
Vol 7 (3-4) ◽  
pp. 186-196 ◽  
Author(s):  
Uma Bhandari ◽  
Hemantkumar Somabhai Chaudhari ◽  
Geetika Khanna ◽  
Abul Kalam Najmi

2007 ◽  
Vol 97 (3) ◽  
pp. 514-521 ◽  
Author(s):  
J. M. A. Hannan ◽  
L. Ali ◽  
B. Rokeya ◽  
J. Khaleque ◽  
M. Akhter ◽  
...  

Trigonella foenum-graecum(fenugreek) seeds have been documented as a traditional plant treatment for diabetes. In the present study, the antidiabetic properties of a soluble dietary fibre (SDF) fraction ofT. foenum-graecumwere evaluated. Administration of SDF fraction (0·5 g/kg body weight) to normal, type 1 or type 2 diabetic rats significantly improved oral glucose tolerance. Total remaining unabsorbed sucrose in the gastrointestinal tract of non-diabetic and type 2 diabetic rats, following oral sucrose loading (2·5 g/kg body weight) was significantly increased byT. foenum-graecum(0·5 g/kg body weight). The SDF fraction suppressed the elevation of blood glucose after oral sucrose ingestion in both non-diabetic and type 2 diabetic rats. Intestinal disaccharidase activity and glucose absorption were decreased and gastrointestinal motility increased by the SDF fraction. Daily oral administration of SDF to type 2 diabetic rats for 28 d decreased serum glucose, increased liver glycogen content and enhanced total antioxidant status. Serum insulin and insulin secretion were not affected by the SDF fraction. Glucose transport in 3T3-L1 adipocytes and insulin action were increased byT. foenum-graecum.The present findings indicate that the SDF fraction ofT. foenum-graecumseeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.


2010 ◽  
Vol 48 (10) ◽  
pp. 1137-1148 ◽  
Author(s):  
V.P. Veerapur ◽  
K.R. Prabhakar ◽  
M.R. Kandadi ◽  
K.K. Srinivasan ◽  
M.K. Unnikrishnan

2014 ◽  
Vol 78 (10) ◽  
pp. 1738-1742 ◽  
Author(s):  
Xiao-Tao Feng ◽  
Qun Chen ◽  
Zhen Xie ◽  
Xiao Liang ◽  
Ze-Hui Jiang ◽  
...  

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