Antihyperglycemic effect of Codariocalyx motorius modulated carbohydrate metabolic enzyme activities in streptozotocin-induced diabetic rats

2014 ◽  
Vol 11 ◽  
pp. 517-527 ◽  
Author(s):  
C. Uma ◽  
N. Suganya ◽  
P. Vanitha ◽  
E. Bhakkiyalakshmi ◽  
S. Suriyanarayanan ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Diabetic Rats ◽  
Metabolic Enzyme ◽  
Antihyperglycemic Effect

scholarly journals Changes in hepatic metabolic enzyme activities and biliary excretion of 4-nitrophenol in streptozotocin induced diabetic rats

2018 ◽  
Vol 54 (1) ◽  
Author(s):  
Attila Almási ◽  
Évora da Ibéria Leite Nogueira Pinto ◽  
Noémi-Piroska Kovács ◽  
Tamás Fischer ◽  
Zoltán Markovics ◽  
...  
Keyword(s):  
Biliary Excretion ◽  
Enzyme Activities ◽  
Diabetic Rats ◽  
Metabolic Enzyme

Effect of experimental diabetes and insulin replacement on intestinal metabolism and excretion of 4-nitrophenol in rats

2015 ◽  
Vol 93 (6) ◽  
pp. 459-464 ◽  
Author(s):  
Emil Fischer ◽  
Attila Almási ◽  
Sztojan Bojcsev ◽  
Tamás Fischer ◽  
Noémi Piroska Kovács ◽  
...  
Keyword(s):  
Small Intestine ◽  
Enzyme Activities ◽  
Experimental Diabetes ◽  
Diabetic Rats ◽  
Metabolic Enzyme ◽  
Intestinal Metabolism ◽  
Insulin Administration ◽  
Perfusion Solution ◽  
Acting Insulin ◽  
Insulin Replacement

Luminal appearance of 4-nitrophenol (PNP) metabolites (4-nitrophenol-β-glucuronide (PNP-G) and 4-nitrophenol-sulfate (PNP-S)) and activity of the related metabolic enzymes have been investigated in control and experimental diabetic rats. Experimental diabetes was induced by administration of streptozotocin (65 mg/kg i.v.). PNP (500 μmol/L) was luminally perfused in the small intestine and the metabolites were determined in the perfusion solution. Effect of insulin replacement was also investigated in the diabetic rats. It was found that experimental diabetes increased the luminal appearance of PNP-G, which could be completely compensated by rapid-acting insulin administration (1 U/kg i.v.). Activities of the enzymes involved in PNP-G production (UDP-glucuronyltransferase and β-glucuronidase) were also elevated; however, these changes were only partially compensated by insulin. Luminal appearance of PNP-S was not significantly changed by administration of streptozotocin and insulin. Activities of the enzymes of PNP-S production (sulfotransferases and arylsulfatases) did not change in the diabetic rats. The results indicate that experimental diabetes can provoke changes in intestinal drug metabolism. It increased intestinal glucuronidation of PNP but did not influence sulfate conjugation. No direct correlation was found between the changes of metabolic enzyme activities and the luminal appearance of the metabolites.

Glutathione metabolic enzyme activities in diabetic platelets as a function of glycemic control

1992 ◽  
Vol 67 (4) ◽  
pp. 385-397 ◽  
Author(s):  
Arumugam Muruganandam ◽  
Christine Drouillard ◽  
Roger J. Thibert ◽  
Raphael M-C.Cheung ◽  
Thomas F.Draisey ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Enzyme Activities ◽  
Metabolic Enzyme

Beneficial Effect of Saharan Propolis on Glucose Metabolism in Streptozotocin-induced Diabetic Rats

2021 ◽  
Vol 21 ◽  
Author(s):  
Mourad Akdad ◽  
Azzoui Bouchra ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Serum Lipid ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Phytochemical Screening ◽  
Antihyperglycemic Effect ◽  
Desert Region ◽  
Beneficial Action ◽  
Ancient Times

Aims: The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco. Background: Propolis is known from ancient times for its beneficial action on health. Objective: The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism. Methods: The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance. Results: This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract). Conclusion: The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.

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