Citrus-derived auraptene stimulates angiogenesis by activating the Erk- and PI3K/Akt/eNOS-dependent signaling pathways in human umbilical vein endothelial cells

2012 ◽  
Vol 4 (4) ◽  
pp. 899-905 ◽  
Author(s):  
Shuaiyu Wang ◽  
Yeo Cho Yoon ◽  
Mi-Jeong Sung ◽  
Jin-Taek Hwang ◽  
Haeng-Jeon Hur ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Signaling Pathways ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

scholarly journals Identification of Key Candidate Genes and Pathways of Candida albicans-Infected Human Umbilical Vein Endothelial Cells and Drug Screening

2019 ◽  
Vol 60 (1) ◽  
pp. 62-69
Author(s):  
Wei Jiang ◽  
Ping Liu ◽  
Jianlei Zhang ◽  
Wenjie Yang
Keyword(s):  
Endothelial Cells ◽  
Candida Albicans ◽  
Signaling Pathways ◽  
Umbilical Vein ◽  
Enrichment Analysis ◽  
Cell Receptor ◽  
Gene Set Enrichment Analysis ◽  
Purine Nucleotide ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

AbstractCandida albicans is a common opportunistic pathogen that can cause serious infection by blood transmission. C. albicans enters the blood circulation and adheres to the endothelial cells of the vascular wall. However, the detailed mechanism of the effect of C. albicans on the endothelial cells remains unclear. In this study, the microarray expression profile of human umbilical vein endothelial cells exposed to C. albicans was analyzed. The 191 up-regulated genes were enriched in TNF, T cell receptor, and NF-kappa B signaling pathways. The 71 down-regulated genes were enriched in pyruvate metabolic, purine nucleotide metabolic, purine nucleotide biosynthetic, and humoral immune response processes. Gene set enrichment analysis showed that apoptosis, oxidative phosphorylation, IL6/JAK/STAT3 signaling pathways were enriched. Moreover, two hub genes with a high degree of connectivity, namely, MYC and IL6, were selected. Molecular screening of traditional Chinese medicine libraries was performed on the basis of the structure of MYC protein. The okanin had the highest docking score. MYC might be used as molecular targets for treatment. In addition, okanin may inhibit the infection of C. albicans. Thus, MYC can be subjected to further research.

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