scholarly journals Antioxidant potential and radioprotective effect of soy isoflavone against gamma irradiation induced oxidative stress

2012 ◽  
Vol 4 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Amit Kumar Dixit ◽  
Deepti Bhatnagar ◽  
Vineet Kumar ◽  
D. Chawla ◽  
K. Fakhruddin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Irradiation ◽  
Radioprotective Effect ◽  
Antioxidant Potential ◽  
Soy Isoflavone

scholarly journals Quantitative Ethnomedicinal Status and Phytochemical Analysis of Berberis lyceum Royle

Agronomy ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 130
Author(s):  
Nausheen Nazir ◽  
Abdur Rahman ◽  
Faheem Uddin ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zahoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chlorogenic Acid ◽  
Local Community ◽  
Antioxidant Activities ◽  
Local Communities ◽  
Antioxidant Potential ◽  
Phytochemical Analysis ◽  
Therapeutic Effects ◽  
Use Value ◽  
Phytochemical Composition

Berberis lyceum Royle has such pronounced medicinal values that it is used as cure of many diseases and has exhibited great therapeutic effects among the local communities throughout the world. The present research was carried out to evaluate the quantitative ethnobotanical status and phytochemical analysis of B. lyceum. Regular field trips were arranged to the study area (Shangla District) in August 2017 to October 2019 and interviews with 100 residents (age range: 30 to 50 years) were conducted. The approach adopted for ethnobotanical data was semi-scientific as the inhabitants were not aware about the modern names of some diseases and therefore physician prescriptions were also consulted. Ethnobotanical data were examined using relative frequency of citation and % use value. The % use value of B. lyceum indicates that the people of District Shangla mostly used it for curing of different diseases. In spite of tremendous uses the plant still survived in this area mainly due to the non-accessibility for humans of the mountain tops; otherwise, increase in anthropogenic activities even in these hilly areas poses a threat of the eradication of this plant. To correlate the folkloric uses with its phytochemical composition, HPLC (high performance liquid chromatography) analysis was performed and a total of six phenolic compounds (quercetin, chlorogenic acid, berberine, rutin, mandellic acid, and hydroxy benzoic acid) were identified in its root. As most of the health complications are correlated to oxidative stress therefore in vitro antioxidant activity were also performed using DPPH (2, 2- diphenyl-1-picrylhydrazyl) and ABTS (2, 2′-azinobis-3-ethyl benzo thiazoline -6- sulfonic acid) assays. The observed antioxidant potential may most probably be due to berberine and chlorogenic acid that were present in highest concentration in the analyzed extract. The effectiveness of the selected plant as remedy for a number of diseases (that were pointed out by the local community) may be due to its phytochemical composition especially berberine and chlorogenic acid as oxidative stress is the root cause of many diseases. The plant extract exhibited high antioxidant potential (DPPH IC50 = 165µg/mL; ABTSIC50 = 110µg/mL) in relation to the detected concentration of berberine and chlorogenic acid. It can be inferred from experimental results that the ethnopharmacological efficacy of this endangered species may be due to its phytochemical composition and antioxidant activities. This case study helps to revive the importance of B. lyceum in local communities and emphasizes the need for its conservation.

scholarly journals Protective and antioxidant potential of the argan oil on induced oxidative stress in Tetrahymena pyriformis

2013 ◽  
Vol 7 (27) ◽  
pp. 1961-1968 ◽  
Author(s):  
Cadi Rachida ◽  
Mounaji Khadija ◽  
Amraoui Fadila ◽  
Soukri Abdelaziz
Keyword(s):  
Oxidative Stress ◽  
Tetrahymena Pyriformis ◽  
Antioxidant Potential ◽  
Argan Oil

scholarly journals Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Nadia Afsheen ◽  
Khalil-ur-Rehman ◽  
Nazish Jahan ◽  
Misbah Ijaz ◽  
Asad Manzoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Medicinal Plants ◽  
Plasmid Dna ◽  
Research Work ◽  
Antioxidant Potential ◽  
Piper Nigrum ◽  
Coronary Artery Ligation ◽  
Hemodynamic Parameters ◽  
Metabolomic Profiling

In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. The C. oxyacantha and T. arjuna showed maximum antioxidant potential, while the E. cardamom showed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2. The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters. The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal. The histopathological examination also confirmed the cardioprotective potential of HC4. Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.

scholarly journals RADIOPROTECTIVE EFFECT OF HUMAN LACTOFERRIN AGAINST GAMMA-IRRADIATION WITH SUBLETHAL DOSE

2020 ◽  
Author(s):  
Marina Yu. Kopaeva ◽  
Irina B. Alchinova ◽  
Mikhail V. Nesterenko ◽  
Anton B. Cherepov ◽  
Marina S. Demorzhi ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Radioprotective Effect ◽  
Human Lactoferrin ◽  
Sublethal Dose

scholarly journals Outcomes Assessment of Sustainable and Innovatively Simple Lifestyle Modification at the Workplace-Drinking Electrolyzed-Reduced Water (OASIS-ERW): A Randomized, Double-Blind, Placebo-Controlled Trial

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 564 ◽  
Author(s):  
Young Ah Choi ◽  
Dong Hyeon Lee ◽  
Doo-Yeoun Cho ◽  
Yong-Jae Lee
Keyword(s):  
Oxidative Stress ◽  
Lifestyle Modification ◽  
Antioxidant Potential ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Health Related ◽  
Stress And Health ◽  
Reduced Water ◽  
Biomarkers Of Oxidative Stress ◽  
Electrolyzed Reduced Water

Oxidative stress has been associated with many diseases as well as aging. Electrolyzed-reduced water (ERW) has been suggested to reduce oxidative stress and improve antioxidant potential. This study investigated the effects of drinking ERW on biomarkers of oxidative stress and health-related indices in healthy adults. We conducted a randomized, double-blind, placebo-controlled clinical trial on 65 participants, who were allocated into two groups. Of these, 61 received intervention (32 with ERW and 29 MW [mineral water]). All participants were instructed to drink 1.5 L/day of ERW or MW for eight weeks. Biomarkers of oxidative stress and health-related indices were assessed at baseline as well as after 4 weeks and 8 weeks of intervention. Of the primary outcome variables assessed, diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential showed a significant interaction between the groups and time, with d-ROMs levels significantly decreased at 8 weeks in ERW compared to those in MW. Among the secondary outcome variables, total, visceral, and subcutaneous fat mass significantly changed over time, with a significant association observed between the group and time. Thus, daily ERW consumption may be a potential consideration for a sustainable and innovatively simple lifestyle modification at the workplace to reduce oxidative stress, increase antioxidant potential, and decrease fat mass.

Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice

2019 ◽  
Vol 52 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Soghra Farzipour ◽  
Fereshteh Talebpour Amiri ◽  
Ehsan Mihandoust ◽  
Fatemeh Shaki ◽  
Zohreh Noaparast ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Radioprotective Effect ◽  
Radiation Induced ◽  
And Oxidative Stress

scholarly journals Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Yasmen F. Mahran ◽  
Amira M. Badr ◽  
Alhanouf Aldosari ◽  
Raghad Bin-Zaid ◽  
Hind N. Alotaibi
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Ovarian Failure ◽  
Radioprotective Effect ◽  
Whole Body ◽  
Nuclear Antigen ◽  
Hormonal Changes ◽  
Tnf Α ◽  
Ovarian Damage ◽  
The Cross

Premature ovarian failure (POF) is a common cause of infertility in premenopausal women who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective cytotoxic treatments. However, the radiosensitivity of ovarian tissues limits its therapeutic outcome and results in the depletion of the primordial follicle and loss of fertility. Therefore, the need for an effective radioprotective therapy is evident especially when none of the current clinically used modalities for radioprotection succeeds efficiently. The present study investigated the potential radioprotective effect of carvacrol (CAR) (80 mg) or thymol (80 mg) on gamma- (γ-) irradiation-induced ovarian damage as well as their role in the cross-talk between IGF-1 and TNF-α signaling and antioxidative activity. In immature female Wister rats, a single dose of whole-body irradiation (3.2 Gy, L D 20 ) produced considerable ovarian damage, which was evident by histopathological findings and hormonal changes. Interestingly, pretreatment with CAR or thymol significantly enhanced the follicular development and restored the anti-Mullerian hormone (AMH), E2, and FSH levels. Both essential oils improved the irradiation-mediated oxidative stress and reduction in proliferating cell nuclear antigen (PCNA) expression. Moreover, irradiated rats exhibited an inverse relationship between IGF-1 and TNF-α levels two days post irradiation, which was further inverted by the pretreatment with CAR and thymol and ought to contribute in their radioprotective mechanisms. In conclusion, CAR and thymol showed a radioprotective effect and rescued the ovarian reserve mainly through counteracting oxidative stress and the dysregulated cross-talk between IGF-1 and TNF-α.

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