Hepatoprotective effect of Forsythiae Fructus water extract against carbon tetrachloride-induced liver fibrosis in mice

2018 ◽  
Vol 218 ◽  
pp. 27-34 ◽  
Author(s):  
Yi Zhang ◽  
Hui Miao ◽  
Hongyu Yan ◽  
Yuchen Sheng ◽  
Lili Ji
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Water Extract ◽  
Hepatoprotective Effect

Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice

2021 ◽  
Author(s):  
Wei-Lun Hung ◽  
Yi-Ting Hsiao ◽  
Yi-Shiou Chiou ◽  
Nagabhushanam Kalyanam ◽  
Chi-Tang Ho ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Broad Spectrum ◽  
Red Wine ◽  
Health Benefits ◽  
Hepatoprotective Effect ◽  
Natural Analog

Piceatannol (3,5,3’,4’-trans-tetrahydroxystilbene) is a natural analog and a metabolite of resveratrol present in grapes and red wine. Previous studies have reported that piceatannol exerts a broad spectrum of health benefits...

The Ethanol-soluble Part of a Hot-water Extract fromArtemisia iwayomogiInhibits Liver Fibrosis Induced by Carbon Tetrachloride in Rats

2000 ◽  
Vol 52 (7) ◽  
pp. 875-881 ◽  
Author(s):  
EUN-JEON PARK ◽  
JI-XING NAN ◽  
JI-YOUNG KIM ◽  
HEE-CHUL KANG ◽  
JUNG HWAN CHOI ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Water Extract ◽  
Hot Water ◽  
Hot Water Extract ◽  
Soluble Part

scholarly journals Hepatoprotective Effect of Ganoderma applanatum Crude Polysaccharides on Carbon Tetrachloride-Induced Early Liver Fibrosis in Mice

2021 ◽  
Vol 13 (6) ◽  
pp. 1428-1436
Author(s):  
Raden Joko Kuncoroningrat Susilo ◽  
Dwi Winarni ◽  
Saikhu Akhmad Husen ◽  
Suhailah Hayaza ◽  
Sri Puji Astuti Wahyuningsih ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Hepatoprotective Effect ◽  
Ganoderma Applanatum

scholarly journals Hepatoprotective Effect of Tagetes Erecta L. Extract on Carbon Tetrachloride Induced Hepatotoxicity in Rats

2019 ◽  
Vol 9 (4-s) ◽  
pp. 269-272
Author(s):  
Kamshetti Manoj Vidyadhar ◽  
Hemant Kumar Sharma
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Water Extract ◽  
Free Radical Scavenger ◽  
Hepatoprotective Effect ◽  
Detoxification Enzymes ◽  
Radical Scavenger ◽  
Tagetes Erecta ◽  
Protective Effects ◽  
Tagetes Erecta L

Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. In this study, the protective effects of water extract of Tagetes erecta L. against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that Tagetes erecta L. Extract could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Keywords: Tagetes erecta L., Carbon Tetrachloride, Liver Damage, Hepato-protection

scholarly journals Correction: Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice

2021 ◽  
Author(s):  
Wei-Lun Hung ◽  
Yi-Ting Hsiao ◽  
Yi-Shiou Chiou ◽  
Kalyanam Nagabhushanam ◽  
Chi-Tang Ho ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Hepatoprotective Effect

Correction for ‘Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice’ by Wei-Lun Hung et al., Food Funct., 2021, DOI: 10.1039/D1FO02545G.

scholarly journals Protective Effect ofPhaleria macrocarpaWater Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-αand TGF-β1

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Nanik Sundari ◽  
Vivian Soetikno ◽  
Melva Louisa ◽  
Bantari W. Wardhani ◽  
Raymond R. Tjandrawinata
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect ◽  
Transforming Growth Factor ◽  
Water Extract ◽  
Control Group ◽  
Sprague Dawley ◽  
Liver Histopathology ◽  
Sprague Dawley Rats ◽  
Phaleria Macrocarpa

Phaleria macrocarpais one of the Indonesian herbal plants which has been shown to have a hepatoprotective effect. This study was conducted to evaluate the protective effect of water extract of mahkota dewa (Phaleria macrocarpa) in liver fibrosis and to elucidate its mechanism of action. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) for 8 weeks to induce liver fibrosis. Rats were randomly divided into 6 groups (n=5), i.e., control group, CCl4 group, CCl4 + NAC group, CCl4 + various doses of water extract ofPhaleria macrocarpa(50, 100, and 150 mg/kg body weight). Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), liver histopathology, malondialdehyde (MDA), ratio GSH/GSSG, Tumor Necrosis Factor- (TNF-)α, and Transforming Growth Factor- (TGF-)β1were analyzed.This study demonstrated that water extract ofPhaleria macrocarpaand NAC significantly protected CCl4-induced liver injury as demonstrated by reduced AST, ALT, ALP, and fibrosis percentage compared with the CCl4-only group. In addition, water extract ofPhaleria macrocarpaand NAC significantly reduced the levels of MDA, TNF-α, and TGF-β1as well as increasing the ratio of GSH/GSSG. Water extract ofPhaleria macrocarpaprevents CCl4-induced fibrosis in rats. The prevention of liver fibrosis was at least in part through its antioxidant and anti-inflammatory activities and through its capacity to inhibit hepatic stellate cells (HSC) activation by reducing fibrogenic cytokine TGF-β1.

Sign in / Sign up

Export Citation Format

Share Document