Corrigendum to “The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis” [J. Ethnopharmacol. 132 (2010) 115–121]

2012 ◽  
Vol 143 (3) ◽  
pp. 924
Author(s):  
Hye-Jin Park ◽  
Eun su Han ◽  
Dong Ki Park
Keyword(s):  
Cell Proliferation ◽  
Ethyl Acetate ◽  
Panax Ginseng ◽  
Melanoma Cell ◽  
Cellular Differentiation ◽  
Ethyl Acetate Extract ◽  
Phellinus Linteus ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cell ◽  
Melanoma Cell Proliferation

Studies on the inhibitory mechanisms of baicalein in B16F10 melanoma cell proliferation

2020 ◽  
Vol 19 (3) ◽  
Author(s):  
W.-H. Hsu ◽  
W.-W. Chang ◽  
J.-R. Sheu ◽  
Y.U.-K. Hsiao ◽  
Y.-J. Tsai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cell ◽  
Inhibitory Mechanisms ◽  
Melanoma Cell Proliferation

scholarly journals Antrodia camphorataGrown on Germinated Brown Rice Suppresses Melanoma Cell Proliferation by Inducing Apoptosis and Cell Differentiation and Tumor Growth

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Minjung Song ◽  
Dong Ki Park ◽  
Hye-Jin Park
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Mouse Model ◽  
Melanoma Cell ◽  
Anticancer Agent ◽  
Brown Rice ◽  
B16f10 Melanoma ◽  
Germinated Brown Rice ◽  
Melanoma Cell Proliferation ◽  
Etoac Fraction

Antrodia camphoratagrown on germinated brown rice (CBR) was prepared to suppress melanoma development. CBR extracts were divided into hexane, EtOAc, BuOH, and water fractions. Among all the fractions, EtOAc fraction showed the best suppressive effect on B16F10 melanoma cell proliferation by CCK-8 assay. It also showed the increased cell death and the changed cellular morphology after CBR treatment. Annexin V-FITC/PI, flow cytometry, and western blotting were performed to elucidate anticancer activity of CBR. The results showed that CBR induced p53-mediated apoptotic cell death of B16F10. CBR EtOAc treatment increased melanin content and melanogenesis-related proteins of MITF and TRP-1 expressions, which supports its anticancer activity. Its potential as an anticancer agent was further investigated in tumor-xenografted mouse model. In melanoma-xenografted mouse model, melanoma tumor growth was significantly suppressed under CBR EtOAc fraction treatment. HPLC analysis of CBR extract showed peak of adenosine. In conclusion, CBR extracts notably inhibited B16F10 melanoma cell proliferation through the p53-mediated apoptosis induction and increased melanogenesis. These findings suggest that CBR EtOAc fraction can act as an effective anticancer agent to treat melanoma.

Insight into Mechanistic Action of Thymoquinone Induced Melanogenesis in Cultured Melanocytes

2019 ◽  
Vol 26 (12) ◽  
pp. 910-918
Author(s):  
Kamal U. Zaidi ◽  
Firoz N. Khan ◽  
Sharique A. Ali ◽  
Kausar P. Khan
Keyword(s):  
Western Blot ◽  
Signaling Pathways ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Protein Kinase Inhibitors ◽  
Tyrosinase Activity ◽  
Dependent Manner ◽  
B16f10 Melanoma ◽  
B16f10 Melanoma Cell

Background: Melanin plays a crucial role in camouflage, social communication and protection against harmful ultraviolet radiations. Melanin is synthesized by melanocytes through melanogenesis and several intrinsic and extrinsic factors are involved during the process. Any change occuring in the normal melanogenesis process can cause severe pigmentation problems of hypopigmentation or hyperpigmentation. Objective: The present study is based on the evaluation of the effect of thymoquinone on melanogenesis and their possible mechanism of action using the B16F10 melanoma cell line for the production via blocking signaling pathways. Methods: Phase contrast microscopy, cell viability, tyrosinase activity, melanin content and western blot analysis were used in the present study. Results: In the present investigation, cultured melanocytes exhibit that the stimulation of melanin synthesis when treated with thymoquinone. Tyrosinase activity and melanin production in B16F10 melanoma cell line was increased in doze-dependent manner. In western blot, we investigated the involvement of the cAMP/PKA pathway in thymoquinone induced melanogenesis. It was observed protein kinase inhibitors PKA, PKC, PKB and MEK1 decreased the stimulatory effects of thymoquinone from 11.45- fold value to 8.312, 6.631, 4.51, and 7.211-fold value, respectively. However, the results also prove that thymoquinone may partially induce tyrosinase expression via PKA, PKB, PKC and MEK1 signaling pathways. Conclusion: The present finding proposed that thymoquinone is a protective challenger for melanogenesis and it might be useful for the treatment of hypopigmentary disorders.

scholarly journals The effect of a novel frizzled 8-related antiproliferative factor on in vitro carcinoma and melanoma cell proliferation and invasion

2011 ◽  
Vol 30 (5) ◽  
pp. 1849-1864 ◽  
Author(s):  
Kristopher R. Koch ◽  
Chen-Ou Zhang ◽  
Piotr Kaczmarek ◽  
Joseph Barchi ◽  
Li Guo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation And Invasion

Increased expression of MAP2 inhibits melanoma cell proliferation, invasion and tumor growth in vitro and in vivo

2010 ◽  
Vol 19 (11) ◽  
pp. 958-964 ◽  
Author(s):  
Zhiqi Song ◽  
Chun-Di He ◽  
Changkai Sun ◽  
Yanni Xu ◽  
Xin Jin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation

scholarly journals microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB

Oncotarget ◽  
2016 ◽  
Vol 7 (22) ◽  
pp. 31663-31680 ◽  
Author(s):  
Keith M. Giles ◽  
Rikki A.M. Brown ◽  
Clarissa Ganda ◽  
Melissa J. Podgorny ◽  
Patrick A. Candy ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation And Metastasis ◽  
Cell Proliferation And Metastasis
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