A facile and sensitive video-analysis method for tracking floating lag-time and floating rate of gastro-retentive tablets

2021 ◽  
Vol 62 ◽  
pp. 102403
Author(s):  
Safwan Abdel Rahim ◽  
Marco Cespi ◽  
Lorina Bisharat ◽  
Alberto Berardi
Keyword(s):  
Video Analysis ◽  
Lag Time ◽  
Analysis Method ◽  
Floating Rate ◽  
Gastro Retentive

Effects of acute methamphetamine administration on spacing in paired rats: Investigation with an automated video-analysis method

1996 ◽  
Vol 20 (6) ◽  
pp. 1037-1049 ◽  
Author(s):  
Toshikazu Shinba ◽  
Ken-Ichi Yamamoto ◽  
Gong-Min Cao ◽  
G.O. Mugishima ◽  
Yoshinori Andow ◽  
...  
Keyword(s):  
Video Analysis ◽  
Analysis Method ◽  
Automated Video Analysis

Design, in vitro and in vivo Evaluation of Gemifloxacin Mesylate Floating Matrix Tablets

1970 ◽  
Vol 9 (1) ◽  
pp. 3143-3149
Author(s):  
Sushma Appala ◽  
Ramesh Bomma ◽  
Kishan Veerabrahma
Keyword(s):  
Helicobacter Pylori ◽  
Drug Release ◽  
Lag Time ◽  
Matrix Tablets ◽  
In Vivo Evaluation ◽  
In Vitro Drug Release ◽  
Weight Variation ◽  
Gastro Retentive

Objective of the investigation was to develop gastro retentive dosage form of gemifloxacin mesylate for local action in the stomach as it has antibacterial activity against Helicobacter pylori. Gemifloxacin mesylate is a synthetic broad-spectrum antibacterial agent for oral administration, having 7 hrs half-life and 71% oral bioavailability. In present study, gemifloxacin mesylate floating matrix tablets were prepared by direct compression method using polymers (HPMC K4M, HPMC K15M and polyox WSR 1105) and evaluated for various parameters like drug content, floating behavior (floating lag time and total floating time), in vitro drug release, swelling index, weight variation, friability, hardness and thickness. Sodium bicarbonate was incorporated as gas generating agent in all formulations. Drug-excipients compatibility was studied by Differential Scanning Calorimetry. Results have shown that the amount of polymer in the formulation affected the drug release. Optimized formulation (F8 containing polyox WSR1105 as release retarding agent) was selected based on in vitro drug release, floating lag time, floating time and other parameters. This formulation followed zero order kinetics and non-Fickian mechanism of drug release. In vivo radiographic study was conducted in healthy human volunteers using tablets containing BaSO4 as radio opaque agent. The average residence time was found to be 4.5± 0.86 h (n=3). This design of gastro retentive drug delivery system helps in increasing the local delivery of drug in patients with Helicobacter pylori infection

scholarly journals Inter-rater reliability of a video-analysis method measuring low-back load in a field situation

2013 ◽  
Vol 44 (5) ◽  
pp. 828-834 ◽  
Author(s):  
Pieter Coenen ◽  
Idsart Kingma ◽  
Cécile R.L. Boot ◽  
Paulien M. Bongers ◽  
Jaap H. van Dieën
Keyword(s):  
Video Analysis ◽  
Low Back ◽  
Analysis Method ◽  
Rater Reliability ◽  
Field Situation

scholarly journals Physico-chemical evaluation of Gastroretentive Ranitidine Hydrochloride: An Anti-Ulcer Drug

2016 ◽  
Vol 3 (2) ◽  
pp. 4-12
Author(s):  
RK Yadav ◽  
Satyam Prakash ◽  
K Yadav ◽  
NK Yadav ◽  
M Mostafa
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Entrapment Efficiency ◽  
Lag Time ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Drug Content ◽  
Drug Entrapment Efficiency ◽  
Gastro Retentive

Background  and  Objectives:  The  prevention  and  treatment  of  peptic  ulcers  has  become  an important challenge in the current medicine  world.   Modern progress in novel drug delivery system aims to improve the efficacy of the drug molecule by formulating a dosage form of RHCL. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in GI tract is to control the gastric residence time.  Therefore, a multi-unit gastro retentive dosage form of RHCL capable of floating on simulated gastric fluid for more than 12 hours was formulated and evaluated.Materials  and  Methods:  Nine  batches  of  the  light  liquid  paraffin  entrapped  emulsion  gel  beads were  prepared  by  a  new  emulsion  gelation  technique  using  sodium  alginate  and  xanthan  gum  as polymers.  The  polymeric  solution  was  extruded  into  Calcium  chloride  solution  by  the  use  of  21G needles.  Morphology  of  beads,  drug  content,  drug  entrapment  efficiency,  floating  lag  time  and buoyancy were studied. Compatibility study of Ranitidine HCl with polymers used in the formulation was performed using DSC and FT-IR.Results:  Mean  surface  diameter  were  between  1.220  ±  2.259%  (F1)  to  1.230  ±  2.316%  (F9)  and floating lag time were between 6 minute (F9) to 11 minute (F1). All formulations were buoyant for more than 12 hours in simulated gastric  fluid  at  37ºC.  The  drug  content  and  drug  entrapment efficiency  among  the  formulations  were  between  17.48%~19.68%  and  71.06%  ~84.32% respectively. Formulation F1 showed lowest drug content and drug entrapment efficiency while F9 showed highest drug content and drug entrapment efficiency. F4 showed most acceptable sustained drug release profile.Conclusion:  The gastro retentive drug delivery system designed as floating beads was found to be satisfactory drug delivery system for Ranitidine HCl to improve the bioavailability of the drug. Janaki Medical College Journal of Medical Sciences (2015) Vol. 3 (2): 4-12

Feasibility Analysis of Laboratory Emulation Study on In-Run Phase of Freestyle Skiing Aerial Athletes

2013 ◽  
Vol 423-426 ◽  
pp. 1771-1777
Author(s):  
Xin Wang ◽  
Yi Ma ◽  
Yan Ming Fu
Keyword(s):  
Video Analysis ◽  
Feasibility Analysis ◽  
Analysis Method ◽  
Significant Difference

In order to summarize the kinematic law of in-run stage of free skiing aerials and identify the feasibility and scientificity of the method of laboratory emulation study, this study employed video analysis method etc. to compare the kinematic indices of laboratory in-run emulation and actual in-run stage on snow. Results show that the actions of our national ski steam are highly identical and there is no significant difference between laboratory and actual parameters. So we can safely come to the conclusion that laboratory emulation is feasible in the analysis of the in-run phase of free skiing aerials.

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