scholarly journals WU and KI polyomavirus infections in pediatric hematology/oncology patients with acute respiratory tract illness

2011 ◽  
Vol 52 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Suchitra Rao ◽  
Robert L. Garcea ◽  
Christine C. Robinson ◽  
Eric A.F. Simões
Keyword(s):  
Respiratory Tract ◽  
Oncology Patients ◽  
Pediatric Hematology ◽  
Respiratory Tract Illness ◽  
Ki Polyomavirus

Nosocomial infections among pediatric hematology/oncology patients: Results of a prospective incidence study

2004 ◽  
Vol 32 (4) ◽  
pp. 205-208 ◽  
Author(s):  
Mireya Urrea ◽  
Susana Rives ◽  
Ofelia Cruz ◽  
Albert Navarro ◽  
Juan José Garcı́a ◽  
...  
Keyword(s):  
Incidence Study ◽  
Nosocomial Infections ◽  
Oncology Patients ◽  
Pediatric Hematology

Prospective analysis of urokinase in the treatment of catheter sepsis in pediatric hematology-oncology patients

1993 ◽  
Vol 28 (3) ◽  
pp. 350-357 ◽  
Author(s):  
Gary R. Jones ◽  
Gwen K. Konsler ◽  
Rose P. Dunaway ◽  
Stuart R. Lacey ◽  
Richard G. Azizkhan
Keyword(s):  
Prospective Analysis ◽  
Oncology Patients ◽  
Pediatric Hematology ◽  
Catheter Sepsis

scholarly journals In SilicoApproach towards Designing Virtual Oligopeptides for HRSV

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ruchi Jain ◽  
Shanmughavel Piramanayagam
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Virus Replication ◽  
Lower Respiratory Tract ◽  
Specific Interaction ◽  
Infection Process ◽  
Rational Choices ◽  
Respiratory Tract Illness ◽  
Syncytial Virus ◽  
Infants And Young Children

HRSV (human respiratory syncytial virus) is a serious cause of lower respiratory tract illness in infants and young children. Designing inhibitors from the proteins involved in virus replication and infection process provides target for new therapeutic treatments. In the present study,in silicodocking was performed using motavizumab as a template to design motavizumab derived oligopeptides for developing novel anti-HRSV agents. Additional simulations were conducted to study the conformational propensities of the oligopeptides and confirmed the hypothesis that the designed oligopeptide is highly flexible and capable of assuming stable confirmation. Our study demonstrated the best specific interaction of GEKKLVEAPKS oligopeptide for glycoprotein strain A among various screened oligopeptides. Encouraged by the results, we expect that the proposed scheme will provide rational choices for antibody reengineering which is useful for systematically identifying the possible ways to improve efficacy of existing antibody drugs.

Day-Care Center Attendance and Hospitalization for Lower Respiratory Tract Illness

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 300-308
Author(s):  
Larry J. Anderson ◽  
Robert A. Parker ◽  
Raymond A. Strikas ◽  
Jeffrey A. Farrar ◽  
Eugene J. Gangarosa ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Day Care ◽  
Lower Respiratory Tract ◽  
Care Center ◽  
Demographic Data ◽  
Care Home ◽  
Univariate Analysis ◽  
Day Care Center ◽  
Respiratory Tract Illness ◽  
Syncytial Virus

To identify risk factors associated with hospitalization for acute lower respiratory tract illness, 102 children <2 years of age admitted to four Atlanta metropolitan area hospitals between December 1984 and June 1985 with the diagnosis of lower respiratory tract illness were studied. The most common causative agent associated with illness was respiratory syncytial virus, followed by other respiratory viruses, Haemophilus influenzae, and Streptococcus pneumoniae. The 102 case-patients were compared with 199 age- and sex-matched controls. A parent or guardian for each patient and control was interviewed by telephone regarding demographic data, care outside the home, breast-feeding, previous medical history, allergies, and smoking and illness in household members. Five factors were associated with lower respiratory tract illness in both a univariate analysis and a multiple logistic regression model (P < .05). These factors were the number of people sleeping in the same room with the child, a lack of immunization the month before the patient was hospitalized, prematurity, a history of allergy, and regular attendance in a day-care center (more than six children in attendance). Care received outside of the home in a day-care home (less than or equal to six children in attendance) was not associated with lower respiratory tract illness. The suggestion made by our study and other studies was that for children <2 years of age, care outside of the home is an important risk factor for acquiring lower respiratory tract illness, as well as other infectious diseases, and that this risk can be reduced by using a day-care home instead of a day-care center.

Surveillance for Nosocomial and Central Line-Related Infections Among Pediatric Hematology-Oncology Patients

2000 ◽  
Vol 21 (9) ◽  
pp. 592-596 ◽  
Author(s):  
Arne Simon ◽  
Gudrun Fleischhack ◽  
Carola Hasan ◽  
Udo Bode ◽  
Steffen Engelhart ◽  
...  
Keyword(s):  
Infection Control ◽  
Home Care ◽  
Nosocomial Infections ◽  
Surveillance System ◽  
Severe Neutropenia ◽  
Prospective Surveillance ◽  
Surveillance Period ◽  
Oncology Patients ◽  
Pediatric Hematology ◽  
Significant Difference

AbstractObjective:To determine the incidence of all nosocomial infections (NIs) in pediatric hematology-oncology patients, as well as central venous access device (CVAD)-associated infections acquired during home care.Design:Prospective surveillance study.Setting:The Pediatric Hematology and Oncology Department at the University Hospital Bonn.Patients:All patients admitted from January through October 1998 (surveillance period).Methods:Standardized surveillance system based on the Centers for Disease Control and Prevention's National Nosocomial Infections Surveillance System.Results:A total of 143 patients were hospitalized for 3,701 days (776 admissions) during the surveillance period. Of the 40 NIs detected, 26 were CVAD-related, with 21 bloodstream infections (BSIs) and 5 local infections. Four were Clostridium difficile-associated diarrheal illnesses, 3 were pneumonias, and 7 were other infections. The incidence of NIs was 10.8 per 1,000 patient-days (5.2 NIs/100 admissions). The overall CVAD-related BSI rate was 7.4 per 1,000 utilization days, without a significant difference between implanted infusion ports and tunneled catheters. In addition, 7 CVAD-related infections occurred during home care. All 8 BSIs associated with tunneled catheters and 13 (76%) of the 17 BSIs associated with ports were acquired nosocomially. For inpatients and outpatients combined, the exit sites of tunneled catheters were more likely to become locally infected than were the needle entry sites of ports (relative risk, 8.0; P=.007). In 30 (75%) of the 40 NIs, the affected patients had severe neutropenia (<500/mm3) at the time of infection.Conclusions:Most NIs in the pediatric hematology-oncology patients were associated with CVAD devices. Although many infections in this high-risk population may not be preventable through infection control measures, the careful evaluation of specific infection rates permits the identification of risk factors that may be targeted by infection control programs. Prospective surveillance for NIs on pediatric oncology units is an indispensable tool for this internal quality control.

scholarly journals Identification of a Third Human Polyomavirus

2007 ◽  
Vol 81 (8) ◽  
pp. 4130-4136 ◽  
Author(s):  
Tobias Allander ◽  
Kalle Andreasson ◽  
Shawon Gupta ◽  
Annelie Bjerkner ◽  
Gordana Bogdanovic ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Large Scale ◽  
Severe Disease ◽  
Amino Acid Identity ◽  
Human Polyomavirus ◽  
Clinical Samples ◽  
Human Pathogens ◽  
Human Respiratory Tract ◽  
Ki Polyomavirus ◽  
Virus Screening

ABSTRACT We have previously reported on a system for large-scale molecular virus screening of clinical samples. As part of an effort to systematically search for unrecognized human pathogens, the technology was applied for virus screening of human respiratory tract samples. This resulted in the identification of a previously unknown polyomavirus provisionally named KI polyomavirus. The virus is phylogenetically related to other primate polyomaviruses in the early region of the genome but has very little homology (<30% amino acid identity) to known polyomaviruses in the late region. The virus was found by PCR in 6 (1%) of 637 nasopharyngeal aspirates and in 1 (0.5%) of 192 fecal samples but was not detected in sets of urine and blood samples. Since polyomaviruses have oncogenic potential and may produce severe disease in immunosuppressed individuals, continued searching for the virus in different medical contexts is important. This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types.

scholarly journals Antibiotic Prescribing by Pediatricians for Respiratory Tract Illness in Children † 507

1998 ◽  
Vol 43 ◽  
pp. 89-89
Author(s):  
Sandra R Arnold ◽  
Upton D Allen ◽  
Mohamed al-Zahrani ◽  
Darrell Tan ◽  
Elaine E L Wang
Keyword(s):  
Respiratory Tract ◽  
Antibiotic Prescribing ◽  
Respiratory Tract Illness

Risk factors for acute respiratory tract illness in military conscripts

Respirology ◽  
2008 ◽  
Vol 13 (4) ◽  
pp. 575-580 ◽  
Author(s):  
Raija JUVONEN ◽  
Aini BLOIGU ◽  
Ari PEITSO ◽  
Sylvi SILVENNOINEN-KASSINEN ◽  
Pekka SAIKKU ◽  
...  
Keyword(s):  
Risk Factors ◽  
Respiratory Tract ◽  
Respiratory Tract Illness

An Outbreak of Mycobacterium mucogenicum Bacteremia in Pediatric Hematology-oncology Patients

2011 ◽  
Vol 30 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Yael Shachor-Meyouhas ◽  
Hannah Sprecher ◽  
Orna Eluk ◽  
Ayelet Ben-Barak ◽  
Imad Kassis
Keyword(s):  
Oncology Patients ◽  
Pediatric Hematology ◽  
Mycobacterium Mucogenicum
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