Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis

2011 ◽  
Vol 51 (3) ◽  
pp. 199-201 ◽  
Author(s):  
Jorge Joven ◽  
Eugenia Espinel ◽  
Anna Rull ◽  
Raúl Beltrán-Debón ◽  
Gerard Aragonès ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Viral Infection ◽  
Fatty Acid Synthase ◽  
Liver Steatosis ◽  
Serum Fatty Acid

scholarly journals Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170721 ◽  
Author(s):  
Sheo B. Singh ◽  
Ling Kang ◽  
Andrea R. Nawrocki ◽  
Dan Zhou ◽  
Margaret Wu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Liver Steatosis ◽  
Synthase Inhibitor

Abstract 1186: Overexpression Of Endothelial Lipase In The Liver Promotes The Clearance Of Plasma Lipids But Accelerates Liver Steatosis In A Mouse Model Of Metabolic Syndrome

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Tomoyuki Yasuda ◽  
Tatsuro Ishida ◽  
Yoko Kojima ◽  
Hanayo Tanaka ◽  
Takeaki Okada ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Mouse Model ◽  
Fatty Acid Synthase ◽  
Plasma Lipids ◽  
Recombinant Adenovirus ◽  
Mrna Level ◽  
Liver Steatosis ◽  
Endothelial Lipase ◽  
The Metabolic Syndrome

The metabolic syndrome includes high triglyceride (TG) and low HDL-cholesterol (HDL-C) levels in the plasma, and often accompanies steatosis in the liver. Endothelial lipase (EL) is a phospholipase that regulates HDL metabolism. EL is expressed by hepatocytes, while the function of EL in the liver has not been identified. Here, we examined the role of EL in the liver using a mouse model of metabolic syndrome. The EL expression in the liver was analyzed by real-time PCR. It revealed that liver EL expression was significantly increased in obese and diabetic db/db mice compared to that of control mice. To examine the significance of the EL upregulation in the liver, we injected the recombinant adenovirus encoding human EL into mice. The EL overexpression in the liver resulted in a significant decrease in plasma HDL-C, TG, and free fatty acid levels. Interestingly, the EL overexpression in the liver increased liver weight and liver TG content both in wild-type and db/db mice. In db/db mice, particularly, EL overexression accelerated the formation of steatosis by increasing the mRNA level of fatty acid synthase. These findings indicate that EL expression is increased in the liver in the metabolic syndrome. The upregulation of EL promotes the uptake of plasma lipids by hepatocytes, and accelerates the progression of steatosis in db/db mice. Thus EL may play a role in the genesis of steatosis as well as dyslipidemia in the metabolic syndrome.

Abstract 166: Elevated levels of serum fatty acid synthase (FAS) in patients with gastric carcinoma.

2013 ◽  
Author(s):  
Tomoaki Ito ◽  
Koichi Sato ◽  
Hiroshi Maekawa ◽  
Takashi Tada ◽  
Mutsumi Sakurada ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gastric Carcinoma ◽  
Fatty Acid Synthase ◽  
Serum Fatty Acid

scholarly journals Dietary chia seed induced changes in hepatic transcription factors and their target lipogenic and oxidative enzyme activities in dyslipidaemic insulin-resistant rats

2012 ◽  
Vol 109 (9) ◽  
pp. 1617-1627 ◽  
Author(s):  
Andrea S. Rossi ◽  
Maria E. Oliva ◽  
Maria R. Ferreira ◽  
Adriana Chicco ◽  
Yolanda B. Lombardo
Keyword(s):  
Fatty Acid ◽  
Enzyme Activities ◽  
Fatty Acid Synthase ◽  
Regulatory Element ◽  
Liver Steatosis ◽  
Control Group ◽  
Acid Oxidase ◽  
Insulin Resistant ◽  
Protein Levels ◽  
Chia Seed

The present study analyses the effect of dietary chia seed rich in n-3 α-linolenic acid on the mechanisms underlying dyslipidaemia and liver steatosis developed in rats fed a sucrose-rich diet (SRD) for either 3 weeks or 5 months. The key hepatic enzyme activities such as fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), glucose-6-phosphate dehydrogenase (G-6-PDH), carnitine palmitoyltransferase-1 (CPT-1) and fatty acid oxidase (FAO) involved in lipid metabolism and the protein mass levels of sterol regulatory element-binding protein-1 (SREBP-1) and PPARα were studied. (1) For 3 weeks, Wistar rats were fed either a SRD with 11 % of maize oil (MO) as dietary fat or a SRD in which chia seed replaced MO (SRD+Chia). (2) A second group of rats were fed a SRD for 3 months. Afterwards, half the rats continued with the SRD while for the other half, MO was replaced by chia for 2 months (SRD+Chia). In a control group, maize starch replaced sucrose. Liver TAG and the aforementioned parameters were analysed in all groups. The replacement of MO by chia in the SRD prevented (3 weeks) or improved/normalised (5 months) increases in dyslipidaemia, liver TAG, FAS, ACC and G-6-PDH activities, and increased FAO and CPT-1 activities. Protein levels of PPARα increased, and the increased mature form of SREBP-1 protein levels in the SRD was normalised by chia in both protocols (1 and 2). The present study provides new data regarding some key mechanisms related to the fate of hepatic fatty acid metabolism that seem to be involved in the effect of dietary chia seed in preventing and normalising/improving dyslipidaemia and liver steatosis in an insulin-resistant rat model.

scholarly journals Serum Fatty Acid Synthase as a Marker of Pancreatic Neoplasia

2009 ◽  
Vol 18 (9) ◽  
pp. 2380-2385 ◽  
Author(s):  
K. Walter ◽  
S.-M. Hong ◽  
S. Nyhan ◽  
M. Canto ◽  
N. Fedarko ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Serum Fatty Acid ◽  
Pancreatic Neoplasia

Elevated levels of serum fatty acid synthase in patients with colorectal cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e14540-e14540
Author(s):  
Tomoaki Ito ◽  
Hajime Orita ◽  
Hiroshi Maekawa ◽  
Mutsumi Sakurada ◽  
Tomoyuki Kushida ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Serum Fatty Acid

scholarly journals Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated

2019 ◽  
Vol 287 ◽  
pp. 38-45 ◽  
Author(s):  
Gayan S. De Silva ◽  
Kshitij Desai ◽  
Malik Darwech ◽  
Uzma Naim ◽  
Xiaohua Jin ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Fatty Acid Synthase ◽  
Artery Stenosis ◽  
Serum Fatty Acid ◽  
Patients With Diabetes
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