Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood

2011 ◽  
Vol 51 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Shouichi Ohga ◽  
Masataka Ishimura ◽  
Goichi Yoshimoto ◽  
Toshihiro Miyamoto ◽  
Hidetoshi Takada ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Nk Cell ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Clonal Origin ◽  
Epstein Barr ◽  
Cell Subpopulations

scholarly journals Clonal origin of Epstein-Barr virus-infected T/NK-cell subpopulations in chronic active Epstein-Barr virus infection

2010 ◽  
Author(s):  
Shouichi Ohga ◽  
Masataka Ishimura ◽  
Goichi Toshimoto ◽  
Toshihiro Miyamoto ◽  
Hidetoshi Takada ◽  
...  
Keyword(s):  
Virus Infection ◽  
Epstein Barr Virus ◽  
Nk Cell ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Clonal Origin ◽  
Epstein Barr ◽  
Cell Subpopulations ◽  
Barr Virus Infection

scholarly journals Epstein–Barr Virus-Positive T/NK-Cell Lymphoproliferative Disorders Manifested as Gastrointestinal Perforations and Skin Lesions

Medicine ◽  
2016 ◽  
Vol 95 (5) ◽  
pp. e2676 ◽  
Author(s):  
Hai-Juan Xiao ◽  
Ji Li ◽  
Hong-Mei Song ◽  
Zheng-Hong Li ◽  
Mei Dong ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Nk Cell ◽  
Skin Lesions ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein–Barr virus-positive T/NK-cell lymphoproliferative disorders

2015 ◽  
Vol 47 (1) ◽  
pp. e133-e133 ◽  
Author(s):  
Qingqing Cai ◽  
Kailin Chen ◽  
Ken H Young
Keyword(s):  
Epstein Barr Virus ◽  
Nk Cell ◽  
Lymphoproliferative Disorders ◽  
Barr Virus ◽  
Epstein Barr

Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients

Blood ◽  
2004 ◽  
Vol 104 (1) ◽  
pp. 243-249 ◽  
Author(s):  
Wing-Yan Au ◽  
Annie Pang ◽  
Carolyn Choy ◽  
Chor-Sang Chim ◽  
Yok-Lam Kwong
Keyword(s):  
Multivariate Analysis ◽  
Natural Killer ◽  
Epstein Barr Virus ◽  
Nk Cell ◽  
Disease Stage ◽  
Tumor Biomarker ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Immunocompetent Patients

Abstract In Epstein-Barr-virus (EBV)–positive lymphomas in immunocompetent patients, release of EBV DNA from tumor cells into the plasma might be useful for disease monitoring and prognostication. To test this hypothesis, we quantified serially plasma EBV DNA by quantitative polymerase chain reaction in 39 cases of EBV-positive (natural killer [NK] cell, n = 23; T cell, n = 8; B cell, n = 4; Hodgkin, n = 4) lymphomas. As control, EBV DNA was undetectable in 34 cases of EBV-negative lymphomas at diagnosis and during chemotherapy. In all cases of EBV-positive lymphomas, EBV DNA was detectable (105-1010 copies/mL) at diagnosis. It paralleled the clinical course, with EBV DNA becoming undetectable at remission and remaining elevated in refractory disease. On multivariate analysis, high-presentation EBV DNA (> 7.3 × 107 copies/mL) was significantly associated with an inferior overall survival (OS). Subgroup analysis of NK cell lymphomas, the largest cohort in this study, showed that presentation EBV DNA was correlated with disease stage and lactate dehydrogenase. On multivariate analysis, high-presentation EBV DNA (> 6.1 × 107 copies/mL) was significantly associated with an inferior disease-free survival. During treatment, patients with EBV DNA that showed further increases or failed to become undetectable had significantly inferior OS. In EBV-positive lymphomas, plasma EBV DNA is valuable as a tumor biomarker and for prognostication.

scholarly journals Hydroa Vacciniforme and Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Spectrum of Disease Phenotypes Associated with Ultraviolet Irradiation and Chronic Epstein–Barr Virus Infection

2020 ◽  
Vol 21 (23) ◽  
pp. 9314
Author(s):  
Chien-Chin Chen ◽  
Kung-Chao Chang ◽  
L Jeffrey Medeiros ◽  
Julia Yu-Yun Lee
Keyword(s):  
T Cell ◽  
Natural Killer ◽  
Ultraviolet Irradiation ◽  
Epstein Barr Virus ◽  
Nk Cell ◽  
Current Evidence ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hydroa Vacciniforme ◽  
Epstein Barr

Hydroa vacciniforme (HV) is a rare form of photosensitivity disorder in children and is frequently associated with Epstein–Barr virus (EBV) infection, whereas HV-like lymphoproliferative disorders (HVLPD) describe a spectrum of EBV-associated T-cell or natural killer (NK)-cell lymphoproliferations with HV-like cutaneous manifestations, including EBV-positive HV, atypical HV, and HV-like lymphoma. Classic HV occurs in childhood with papulovesicules on sun-exposed areas, which is usually induced by sunlight and ultraviolet irradiation, and mostly resolves by early adult life. Unlike classic HV, atypical or severe HV manifests itself as recurrent papulovesicular eruptions in sun-exposed and sun-protected areas associated occasionally with facial edema, fever, lymphadenopathy, oculomucosal lesions, gastrointestinal involvement, and hepatosplenomegaly. Notably, atypical or severe HV may progress to EBV-associated systemic T-cell or natural killer (NK)-cell lymphoma after a chronic course. Although rare in the United States and Europe, atypical or severe HV and HV-like lymphoma are predominantly reported in children from Asia and Latin America with high EBV DNA levels, low numbers of NK cells, and T cell clones in the blood. In comparison with the conservative treatment used for patients with classic HV, systemic therapy such as immunomodulatory agents is recommended as the first-line therapy for patients with atypical or severe HV. This review aims to provide an integrated overview of current evidence and knowledge of HV and HVLPD to elucidate the pathophysiology, practical issues, environmental factors, and the impact of EBV infection.

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