scholarly journals Role of intravenous zoledronic acid in management of giant cell tumor of bone- A prospective, randomized, clinical, radiological and electron microscopic analysis

2019 ◽  
Vol 10 (6) ◽  
pp. 1021-1026 ◽  
Author(s):  
Siddharth Dubey ◽  
Shishir Rastogi ◽  
Venkatesan Sampath ◽  
Shah Alam Khan ◽  
Arvind Kumar
Keyword(s):  
Zoledronic Acid ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Microscopic Analysis ◽  
Cell Tumor ◽  
Electron Microscopic Analysis ◽  
Electron Microscopic

Role of radiologic imaging in management planning of giant cell tumor of bone

1984 ◽  
Vol 12 (2) ◽  
pp. 79-89 ◽  
Author(s):  
E. Levine ◽  
A. A. De Smet ◽  
J. R. Neff
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Management Planning ◽  
Radiologic Imaging

RECURRENCE OF GIANT CELL TUMOR OF BONE: THE ROLE OF MRI IN DIAGNOSIS

Orthopedics ◽  
1997 ◽  
Vol 20 (1) ◽  
pp. 67-69
Author(s):  
Barry J Waldman ◽  
Elias A Zerhouni ◽  
Frank J Frassica
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

scholarly journals Role of Bisphosphonates as Adjuvants of Surgery in Giant Cell Tumor of Spine

10.14444/5087 ◽  
2018 ◽  
Vol 12 (6) ◽  
pp. 695-702
Author(s):  
CHAITANYA DEV PANNU ◽  
PANKAJ KANDHWAL ◽  
VIJAY RAGHAVAN ◽  
SHAH ALAM KHAN ◽  
SHISHIR RASTOGI ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor

Giant Cell Tumor of Tendon Sheath: Immunohistochemical Study of 20 Cases

1997 ◽  
Vol 83 (5) ◽  
pp. 841-846 ◽  
Author(s):  
Antonio Cavaliere ◽  
Angelo Sidoni ◽  
Emilio Bucciarelli
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Neuron Specific Enolase ◽  
Synovial Cell ◽  
Tendon Sheath ◽  
Giant Cells ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Filament Bundles

Aims and background Giant cell tumor of tendon sheath (GCTTS) is a common tumor occurring on the tendon sheaths of the fingers. The nature of this lesion is still controversial: some researchers consider it a reactive process arising from chronic inflammation while others regard it as a tumor of presumed synovial cell or monocytic macrophage system origin. In an effort to clarify the histogenesis we decided to further investigate the immunophenotypic profile of this tumor. Study design We studied 20 GCTTS of the fingers using a panel of 18 antibodies, 13 monoclonal and 5 polyclonal. Results The immunohistochemical investigation revealed that the mononuclear cells of this lesion can be divided into two groups. The cells of the first and more numerous group were positive for vimentin, PG-M1 and KP1 but also for muscle actin (HHF35 monoclonal antibody) and neuron-specific enolase. A second population of mononuclear cells, usually arranged around the giant cells, were positive for PG-M1, KP1, LCA and occasionally for alpha-1-antitrypsin and alpha-1-antichymotrypsin. Multinucleated giant cells were also positive for KP1, PG-M1 and LCA monoclonal antibodies. A variable but usually weak positivity for al-pha-1-antitrypsin, alpha-1-antichymotrypsin and lysozyme was also observed. Conclusions Our results suggest a synovial cell origin for GCTTS and do not support the hypothesis that it could be a neoplasm with a true histiocytic origin. The positivity of some cells for the HHF35 antibody, together with electron microscopic evidence of filament bundles with focal dense bodies, suggests that at least part of the mononuclear cells may have a myofibroblastic differentiation.

scholarly journals The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shalini Singh ◽  
Isabella W. Y. Mak ◽  
Divya Handa ◽  
Michelle Ghert
Keyword(s):  
Cell Migration ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Epithelial Mesenchymal Transition ◽  
Cell Tumor ◽  
Stable Cell Line ◽  
Mesenchymal Transition

Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth. The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown. The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers. In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration. Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression. A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin. The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.

Giant cell tumor of the plantar tendon sheath: Role of MR imaging in diagnosis case report

1993 ◽  
Vol 17 (2) ◽  
pp. 153-155 ◽  
Author(s):  
Edward H. Demouy ◽  
Kuniyuki Kaneko ◽  
Howard M. Bear ◽  
Raoul P. Rodriguez
Keyword(s):  
Case Report ◽  
Mr Imaging ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tendon Sheath ◽  
Cell Tumor

Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study

2015 ◽  
Vol 33 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
Irene Quattrini ◽  
Serena Pollino ◽  
Laura Pazzaglia ◽  
Amalia Conti ◽  
Chiara Novello ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Bone Remodeling ◽  
Cell Tumor ◽  
Nuclear Factor ◽  
Prognostic Role
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