Comparative analysis of prognostic markers for aggressiveness of giant cell tumour

2015 ◽  
Vol 6 (1) ◽  
pp. 65-66
Author(s):  
Chaitanya dev
Keyword(s):  
Comparative Analysis ◽  
Giant Cell ◽  
Prognostic Markers ◽  
Giant Cell Tumour ◽  
Cell Tumour

scholarly journals Aberrant sphingomyelin 31P-NMR signatures in giant cell tumour of bone

2021 ◽  
Author(s):  
Tayde Quiroz-Acosta ◽  
Yazmin Montserrat Flores-Martinez ◽  
Elvia Becerra-Martínez ◽  
Elizabeth Pérez-Hernández ◽  
Nury Pérez-Hernández ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Giant Cell ◽  
Prognostic Markers ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Resonance Spectroscopy ◽  
Metabolomic Analysis ◽  
Tissue Samples ◽  
Altered Pathway ◽  
Low Expression

An understanding of the biochemistry of the giant cell tumour of bone (GCTB) provides an opportunity for the development of prognostic markers and identification of therapeutic targets. Based on metabolomic analysis, we proposed glycerophospholipid metabolism as the altered pathway in GCTB and the objective of this study was to identify these altered metabolites. Using phosphorus-31 nuclear magnetic resonance spectroscopy (<sup>31</sup>P-NMR), sphingomyelin was determined as the most dysregulated phospholipid in tissue samples from six patients with GCTB; subsequently, enzymes related to its biosynthesis and hydrolysis were examined using immunodetection techniques. High expression of sphingomyelin synthases 1 and 2, but low expression of neutral sphingomyelinase 2 (nSMase2), was found in GCTB tissues compared to non-neoplastic bone tissues. Sphingomyelin/ ceramide biosynthesis is dysregulated in GCTB due to alterations in the expression of SMS1, SMS2, and nSMase2.

scholarly journals AB0049 Rheumatoid arthritis and giant cell tumour of the tendon sheath: A case report

2001 ◽  
Author(s):  
S Kiraz ◽  
D Altýnok ◽  
Ý Ertenli ◽  
MA Öztürk ◽  
S Apras ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Tendon Sheath ◽  
Cell Tumour

scholarly journals Giant-cell tumour of bone: cytological studies

1979 ◽  
Vol 40 (2) ◽  
pp. 201-209 ◽  
Author(s):  
K Kasahara ◽  
T Yamamuro ◽  
A Kasahara
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour

Giant-cell tumour of bone metastasising to the lungs

1998 ◽  
Vol 80-B (1) ◽  
pp. 43-47 ◽  
Author(s):  
K. A. Siebenrock ◽  
K. K. Unni ◽  
M. G. Rock
Keyword(s):  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour

Giant cell tumour of the first metatarsal: a case report

2004 ◽  
Vol 14 (1) ◽  
pp. 40-41
Author(s):  
Roop Singh ◽  
Ashwini Sharma ◽  
N. K. Magu ◽  
Rajeev Mittal
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
First Metatarsal
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