scholarly journals Modulating smooth muscle cell response by the release of TGFβ2 from tubular scaffolds for vascular tissue engineering

2019 ◽  
Vol 299 ◽  
pp. 44-52 ◽  
Author(s):  
D.C. Ardila ◽  
E. Tamimi ◽  
T. Doetschman ◽  
W.R. Wagner ◽  
J.P. Vande Geest
Keyword(s):  
Tissue Engineering ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Response ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering

scholarly journals Integrin-Linked Kinase in the Vascular Smooth Muscle Cell Response to Injury

2008 ◽  
Vol 173 (1) ◽  
pp. 278-288 ◽  
Author(s):  
Bernard Ho ◽  
Guangpei Hou ◽  
J. Geoffrey Pickering ◽  
Gregory Hannigan ◽  
B. Lowell Langille ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Response ◽  
Integrin Linked Kinase

The Effect of Dynamical Strain on the Maturation of Collagen-Based Cell-Containing Scaffolds for Vascular Tissue Engineering

2011 ◽  
Vol 409 ◽  
pp. 152-157 ◽  
Author(s):  
Lucie Levesque ◽  
D. Mantovani
Keyword(s):  
Tissue Engineering ◽  
Smooth Muscle ◽  
Blood Vessel ◽  
Smooth Muscle Cells ◽  
Vascular Tissue ◽  
Muscle Cells ◽  
Collagen Fibrils ◽  
Vascular Tissue Engineering ◽  
Silicone Membrane ◽  
Custom Made

Diseases occurring to blood vessel are preferentially solved by replacing the vessel by an autologous graft. When it is not available, a synthetic graft is used which has low patency rates for small diameter (<6 mm) vessels. Tissue engineering of blood vessel aims to improve the performance of vascular substitutes. Bioreactors are used in vascular tissue engineering to mimic the mechanical and biochemical environment of blood vessel. A 2D bioreactor was custom made in order to impose a dynamical strain to silicone membrane receiving the collagen cell-based construct. Collagen gels with vascular smooth muscle cells cultured inside were subdued to maturation under dynamical uniaxial stretch regimes at 1Hz for 48 hours. The percentage of deformation encountered by the silicone membrane was measured by ImageJ. Collagen fibrils and porcine smooth muscle cells (PSMC) orientations were assessed by scanning electron microscopy (SEM). Results show that the study of mechanical conditioning on cell activity is an important issue for enhancing the alignment of collagen fibrils.

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