scholarly journals Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy

2016 ◽  
Vol 238 ◽  
pp. 289-299 ◽  
Author(s):  
Alinda R. Fernandes ◽  
Divya M. Chari
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Stem Cell Therapy ◽  
Ex Vivo ◽  
Dna Size

Mesenchymal Stem Cell Therapy for Ex Vivo Repair of Ischemic Injury in Pig Donor Lungs

2017 ◽  
Vol 36 (4) ◽  
pp. S68 ◽  
Author(s):  
D. Nakajima ◽  
Y. Watanabe ◽  
A. Ohsumi ◽  
M. Pipkin ◽  
M. Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Ex Vivo ◽  
Ischemic Injury ◽  
Mesenchymal Stem Cell Therapy

P3-345: Restoration of memory in mouse models of Alzheimer's disease and neuronal loss: A new paradigm using human neural stem cell therapy

2012 ◽  
Vol 8 (4S_Part_16) ◽  
pp. P577-P578
Author(s):  
Mathew Blurton-Jones ◽  
Rahasson Ager ◽  
Joy Nerhus ◽  
Andy Agazaryan ◽  
Stephen Huhn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Mouse Models ◽  
Stem Cell Therapy ◽  
Neuronal Loss ◽  
New Paradigm ◽  
Human Neural Stem Cell

Lentivirus-mediated CD/TK fusion gene transfection neural stem cell therapy for C6 glioblastoma

Tumor Biology ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 3731-3741 ◽  
Author(s):  
Jian Niu ◽  
Chunyang Xing ◽  
Chao Yan ◽  
Hao Liu ◽  
Yuqiong Cui ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Stem Cell Therapy ◽  
Fusion Gene ◽  
Gene Transfection

scholarly journals Neuronal Replacement in Stem Cell Therapy for Stroke: Filling the Gap

2021 ◽  
Vol 9 ◽  
Author(s):  
Sara Palma-Tortosa ◽  
Berta Coll-San Martin ◽  
Zaal Kokaia ◽  
Daniel Tornero
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Cell Therapy ◽  
Human Skin ◽  
Stem Cell Therapy ◽  
Ex Vivo ◽  
Functional Integration ◽  
Short Review ◽  
Neuronal Replacement

Stem cell therapy using human skin-derived neural precursors holds much promise for the treatment of stroke patients. Two main mechanisms have been proposed to give rise to the improved recovery in animal models of stroke after transplantation of these cells. First, the so called by-stander effect, which could modulate the environment during early phases after brain tissue damage, resulting in moderate improvements in the outcome of the insult. Second, the neuronal replacement and functional integration of grafted cells into the impaired brain circuitry, which will result in optimum long-term structural and functional repair. Recently developed sophisticated research tools like optogenetic control of neuronal activity and rabies virus monosynaptic tracing, among others, have made it possible to provide solid evidence about the functional integration of grafted cells and its contribution to improved recovery in animal models of brain damage. Moreover, previous clinical trials in patients with Parkinson’s Disease represent a proof of principle that stem cell-based neuronal replacement could work in humans. Our studies with in vivo and ex vivo transplantation of human skin-derived cells neurons in animal model of stroke and organotypic cultures of adult human cortex, respectively, also support the hypothesis that human somatic cells reprogrammed into neurons can get integrated in the human lesioned neuronal circuitry. In the present short review, we summarized our data and recent studies from other groups supporting the above hypothesis and opening new avenues for development of the future clinical applications.

Neural stem cell therapy—Brief review

2018 ◽  
Vol 173 ◽  
pp. 8-14 ◽  
Author(s):  
Cezary Grochowski ◽  
Elżbieta Radzikowska ◽  
Ryszard Maciejewski
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Neural Stem Cell ◽  
Stem Cell Therapy
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