Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations

2012 ◽  
Vol 157 (3) ◽  
pp. 383-390 ◽  
Author(s):  
S. Al-Qadi ◽  
A. Grenha ◽  
D. Carrión-Recio ◽  
B. Seijo ◽  
C. Remuñán-López
Keyword(s):  
Protein Delivery ◽  
Chitosan Nanoparticles ◽  
In Vivo Evaluation

Formulation of Gliclazide Encapsulated Chitosan Nanoparticles: In Vitro and In Vivo Evaluation

2012 ◽  
pp. 77-85 ◽  
Author(s):  
Ranjith Kumar Averineni ◽  
Gopal Venkatesh Shavi ◽  
Om Prakash Ranjan ◽  
Praful Balavant Deshpande ◽  
Gurram Aravind Kumar ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Evaluation

Preparation and Evaluation of 6-Maleimidohexanoic Acid Grafted Chitosan Nanoparticles as a Novel Carrier for Intranasal Protein Delivery

2020 ◽  
Vol 859 ◽  
pp. 214-219
Author(s):  
Ekachai Dumkliang ◽  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Prasopchai Patrojanasophon ◽  
Boonnada Pamornpathomkul ◽  
...  
Keyword(s):  
Protein Delivery ◽  
Ex Vivo ◽  
Chitosan Nanoparticles ◽  
Fluorescein Isothiocyanate ◽  
Protein Loading ◽  
Before And After ◽  
Model Protein ◽  
Preparation And Evaluation ◽  
Positively Charged

In this study, 6-maleimidohexanoic acid grafted chitosan nanoparticles (MHA-CS NPs) were prepared and evaluated the efficiency of intranasal protein delivery as compared with well-known chitosan nanoparticles (CS NPs). Fluorescein isothiocyanate labelled with bovine serum albumin (FITC-BSA) was used as a model protein. The results indicated that both CS NPs and MHA-CS NPs were positively charged NPs before and after protein loading. The condition for optimal protein loading was 1:6 mass ratio of protein/NPs at 1 h incubation period. The optimal formulations of CS NPs and MHA-CS NPs were evaluated on porcine mucosa as ex vivo. The mucoadhesive and permeation properties of FITC-BSA loaded MHA-CS NPs showed a greater than FITC-BSA loaded CS NPs and FITC-BSA solution, respectively. These ex vivo studies present the potential of MHA-CS NPs as a novel carrier for intranasal protein delivery that will be a candidate for in vivo study.

Simvastatin nanoparticles loaded polymeric film as a potential strategy for diabetic wound healing: in vitro and in vivo evaluation

2021 ◽  
Vol 18 ◽  
Author(s):  
Saima Tufail ◽  
Muhammad Irfan Siddique ◽  
Muhammad Sarfraz ◽  
Muhammad Farhan Sohail ◽  
Muhammad Nabeel Shahid ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Chitosan Nanoparticles ◽  
Albino Rats ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
In Vivo Evaluation ◽  
Diabetic Wound Healing

Introduction: The pleiotropic effects of statins are recently explored for wound healing through angiogenesis and lymph-angiogenesis that could be of great importance in diabetic wounds. Aim: Aim of the present study is to fabricate nanofilm embedded with simvastatin loaded chitosan nanoparticles (CS-SIM-NPs) has been reported herein to explore the efficacy of SIM in diabetic wound healing. Methods: The NPs, prepared via ionic gelation, were 173nm ± 2.645 in size with a zeta potential -0.299 ± 0.009 and PDI 0.051 ± 0.088 with excellent encapsulation efficiency (99.97%). The optimized formulation (CS: TPP, 1:1) that exhibited the highest drug release (91.64%) was incorporated into polymeric nanofilm (HPMC, Sodium alginate, PVA), followed by in vitro characterization. The optimized nanofilm was applied to the wound created on the back of diabetes-induced (with alloxan injection 120 mg/kg) albino rats. Results: The results showed significant (p < 0.05) improvement in the wound healing process compared to the diabetes-induced non-treated group. The results highlighted the importance of nanofilms loaded with SIM-NPs in diabetic wound healing through angiogenesis promotion at the wound site. Conclusion: Thus, CS-SIM-NPs loaded polymeric nanofilms could be an emerging diabetic wound healing agent in the industry of nanomedicines.

scholarly journals In Vitro and in Vivo Evaluation of Osteoporosis Therapeutic Peptide PTH 1–34 Loaded PEGylated Chitosan Nanoparticles

2013 ◽  
Vol 10 (11) ◽  
pp. 4159-4167 ◽  
Author(s):  
Deepa Narayanan ◽  
A. Anitha ◽  
R. Jayakumar ◽  
K. P. Chennazhi
Keyword(s):  
Chitosan Nanoparticles ◽  
In Vivo Evaluation ◽  
Therapeutic Peptide
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