Application of drug selective electrode in the drug release study of pH-responsive microgels

2007 ◽  
Vol 118 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Jeremy P.K. Tan ◽  
Kam C. Tam
Keyword(s):  
Drug Release ◽  
Ph Responsive ◽  
Selective Electrode ◽  
Drug Release Study ◽  
Release Study

pH-Responsive sulphonated mesoporous silica: a comparative drug release study

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 57929-57940 ◽  
Author(s):  
Mohamad M. Ayad ◽  
Nehal A. Salahuddin ◽  
Nagy L. Torad ◽  
Ahmed Abu El-Nasr
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Surface Functionalization ◽  
High Surface ◽  
Ph Responsive ◽  
Drug Release Study ◽  
Surface Areas ◽  
Silica Materials ◽  
Mesoporous Silica Materials ◽  
Release Study

Control of morphology and surface functionalization of mesoporous silica materials have enhanced the biocompatibility of these materials with high surface areas and total pore volumes.

Formulation and Evaluation of Transdermal patch of Methimazole

2021 ◽  
pp. 4667-4672
Author(s):  
Nani Tadhi ◽  
Himansu Chopra ◽  
Gyanendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Transdermal Patch ◽  
Formulation Development ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Percent Moisture ◽  
Release Study

Transdermal patch is a drug delivery device in which the drugs are incorporated and is design in such a way that it releases the drug in sustained and at predetermined rate to deliver the drug through the skin to the systemic circulation painlessly. The aim of this research study was to formulate a controlled and sustained release transdermal matrix type patch of Methimazole. The matrix patch was prepared by solvent casting method using a various polymer in different concentration, HPMC (hydrophilic), Eudragit RL100 and Ethyl cellulose (hydrophobic) polymer. Total 9 prototype formulation were prepared and it was subjected for various evaluation test; weight uniformity, Folding endurance, thickness, Drug content, percent moisture content, percent Moisture uptake and In-vitro drug release study using Franz diffusion cell. The in-vitro CDR% data was fit into kinetics model to see the release kinetics from the patches. The Formulation F5 was choosen as a best formulation according to in-vitro drug release study. The in-vitro release was found 81.12 % in 12 hours, it followed zero order kinetics. The nature of polymer and concentration ratio of polymers plays a crucial role for obtaining a good transdermal patch design; therefore optimisation is very important step to formulate a desired TDDS. Therefore the result of the study encourages a further study and is hopeful that the present study would contribute to the recent pharmaceutical research for formulation development.

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (07) ◽  
pp. 52-57
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Release Profile ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Drug Release Study ◽  
Drug Content ◽  
Release Study

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of formulation variables on responses R1 (% swelling index), R2 (% drug content), R3 (mucoadhesion time) and R4 (mucoadhesion strength). In vitro drug release study was performed on the optimized formulations. All the prepared formulations had good mechanical strength, mucoadhesion strength, neutral surface pH and drug content up to 98.17%. In vitro drug release study revealed that F-5 formulation showed promising sustained drug release profile (98.21%) for over 8 h and could be a potential substitute for marketed conventional formulations. The developed formulation (F5) was found to be optimized with considerably good stability and extended drug release profile.

Comparative drug release study from artificially engineered DOX loaded MPEG-PLA nanoparticles

2008 ◽  
Vol 136 ◽  
pp. S196
Author(s):  
Eunjung Kim ◽  
Jaemoon Yang ◽  
Jin-Suck Suh ◽  
Yong-Min Huh ◽  
Seungjoo Haam
Keyword(s):  
Drug Release ◽  
Drug Release Study ◽  
Release Study

scholarly journals The Drug Release Study of Ceftriaxone from Porous Hydroxyapatite Scaffolds

2009 ◽  
Vol 10 (3) ◽  
pp. 772-779 ◽  
Author(s):  
Zeki N. Al-Sokanee ◽  
Abedl Amer H. Toabi ◽  
Mohammed J. Al-assadi ◽  
Erfan A. S. Alassadi
Keyword(s):  
Drug Release ◽  
Porous Hydroxyapatite ◽  
Drug Release Study ◽  
Release Study
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