Enhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (generation 3, G3)

2006 ◽  
Vol 116 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Hidetoshi Arima ◽  
Yuko Chihara ◽  
Masayo Arizono ◽  
Shogo Yamashita ◽  
Koki Wada ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Transfer Activity

Liposomal Polyamine−Dialkyl Phosphate Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity

2010 ◽  
Vol 21 (5) ◽  
pp. 844-852 ◽  
Author(s):  
Takehisa Dewa ◽  
Tomohiro Asai ◽  
Yuka Tsunoda ◽  
Kiyoshi Kato ◽  
Daisuke Baba ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Chemical Structure ◽  
Transfer Activity ◽  
Gene Carriers ◽  
Structure Morphology ◽  
Dialkyl Phosphate

scholarly journals In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Keiichi Motoyama ◽  
Yoshihiro Nakashima ◽  
Yukihiko Aramaki ◽  
Fumitoshi Hirayama ◽  
Kaneto Uekama ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Plasmid Dna ◽  
Transfection Efficiency ◽  
Cationic Liposomes ◽  
Nonviral Vector ◽  
Liposomal Membrane ◽  
Transfer Activity ◽  
Potential Use

The purpose of this study is to evaluate in vitro gene delivery mediated by asialofetuin-appended cationic liposomes (AF-liposomes) associating cyclodextrins (CyD/AF-liposomes) as a hepatocyte-selective nonviral vector. Of various CyDs, AF-liposomes associated with plasmid DNA (pDNA) and γ-cyclodextrin (γ-CyD) (pDNA/γ-CyD/AF-liposomes) showed the highest gene transfer activity in HepG2 cells without any significant cytotoxicity. In addition, γ-CyD enhanced the encapsulation ratio of pDNA with AF-liposomes, and also increased gene transfer activity as the entrapment ratio of pDNA into AF-liposomes was increased. γ-CyD stabilized the liposomal membrane of AF-liposomes and inhibited the release of calcein from AF-liposomes. The stabilizing effect of γ-CyD may be, at least in part, involved in the enhancing gene transfer activity of pDNA/γ-CyD/AF-liposomes. Therefore, these results suggest the potential use of γ-CyD for an enhancer of transfection efficiency of AF-liposomes.

Effects of a Novel Archaeal Tetraether-Based Colipid on the In Vivo Gene Transfer Activity of Two Cationic Amphiphiles

2014 ◽  
Vol 11 (9) ◽  
pp. 2973-2988 ◽  
Author(s):  
Tony Le Gall ◽  
Julie Barbeau ◽  
Sylvain Barrier ◽  
Mathieu Berchel ◽  
Loïc Lemiègre ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Cationic Amphiphiles ◽  
Transfer Activity ◽  
In Vivo Gene Transfer

Possible enhancing mechanisms for gene transfer activity of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate

2012 ◽  
Vol 426 (1-2) ◽  
pp. 239-247 ◽  
Author(s):  
Takayuki Anno ◽  
Taishi Higashi ◽  
Keiichi Motoyama ◽  
Fumitoshi Hirayama ◽  
Kaneto Uekama ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Transfer Activity

scholarly journals Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity

Gene Therapy ◽  
2007 ◽  
Vol 14 (15) ◽  
pp. 1160-1165 ◽  
Author(s):  
S Kurachi ◽  
K Tashiro ◽  
F Sakurai ◽  
H Sakurai ◽  
K Kawabata ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Tat Peptide ◽  
Transfer Activity ◽  
Efficient Gene ◽  
Adenovirus Vectors ◽  
Hiv 1

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

2005 ◽  
Vol 13 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Alan L. Parker ◽  
Kerry D. Fisher ◽  
David Oupicky ◽  
Martin L. Read ◽  
Stuart A. Nicklin ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Targeted Gene Delivery ◽  
Transfer Activity ◽  
Gene Delivery Vectors
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