Saliva diagnostics in patients suffering from bisphosphonate-associated osteonecrosis of the jaw: Results of an observational study

2020 ◽  
Vol 48 (2) ◽  
pp. 176-180 ◽  
Author(s):  
Philipp Stockmann ◽  
Tobias Ebker ◽  
Jasmin Bergauer ◽  
Falk Wehrhan
Keyword(s):  
Observational Study ◽  
Osteonecrosis Of The Jaw ◽  
Saliva Diagnostics

scholarly journals A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1209
Author(s):  
Satoe Okuma ◽  
Yuhei Matsuda ◽  
Yoshiki Nariai ◽  
Masaaki Karino ◽  
Ritsuro Suzuki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Observational Study ◽  
Bone Metastases ◽  
Hormone Therapy ◽  
Stage Iv ◽  
Underlying Disease ◽  
Osteonecrosis Of The Jaw ◽  
Apical Periodontitis ◽  
Retrospective Observational Study ◽  
Solid Cancer

This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2–52 months). Univariate analyses showed a statistically significant correlation between DRONJ and hormone therapy, chemotherapy/molecular target drug, apical periodontitis, periodontal disease, sex and body mass index. Multivariate analysis showed a statistically significant correlation between DRONJ and hormone therapy (odds ratio [OR], 22.07; 95% confidence interval [CI], 2.86–170.24), chemotherapy and/or molecular targeted therapy (OR, 18.61; 95% CI, 2.54–136.27), and apical periodontitis (OR, 22.75; 95% CI, 3.20–161.73). These findings imply that collaborative oral examinations by oral specialists may reduce the risk of development of DRONJ in patients treated with denosumab for bone metastases from solid cancers.

First clinical experience with the Multi-LOC multiple stent delivery system for focal stenting in long femoro-popliteal lesions

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 452-461 ◽  
Author(s):  
Klaus Amendt ◽  
Ulrich Beschorner ◽  
Matthias Waliszewski ◽  
Martin Sigl ◽  
Ralf Langhoff ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Experience ◽  
Delivery System ◽  
Target Lesion ◽  
Lesion Length ◽  
Elastic Recoil ◽  
Delivery Device ◽  
Clinical Assessments ◽  
Balloon Catheters ◽  
Considerable Length

Abstract. Background: The purpose of this observational study is to report the six-month clinical outcomes with a new multiple stent delivery system in patients with femoro-popliteal lesions. Patients and methods: The LOCOMOTIVE study is an observational multicentre study with a primary endpoint target lesion revascularization (TLR) rate at six months. Femoro-popliteal lesions were prepared with uncoated and/or paclitaxel-coated peripheral balloon catheters. When flow limiting dissections, elastic recoil or recoil due to calcification required stenting, up to six short stents per delivery device, each 13 mm in length, were implanted. Sonographic follow-ups and clinical assessments were scheduled at six months. Results: For this first analysis, a total of 75 patients 72.9 ± 9.2 years of age were enrolled. The majority of the 176 individually treated lesions were in the superficial femoral artery (76.2 %, 134/176) whereas the rate of TASC C/D amounted to 51.1 % (90/176). The total lesion length was 14.5 ± 9.0 cm with reference vessel diameters of 5.6 ± 0.7 mm. Overall 47 ± 18 % of lesion lengths could be saved from stenting. At six months, the patency was 90.7 % (68/75) and all-cause TLR rates were 5.3 % (4/75) in the overall cohort. Conclusions: The first clinical experience at six months suggests that the MSDS strategy was safe and effective to treat femoro-popliteal lesions of considerable length (14.5 ± 9.0 cm). Almost half of the lesion length could be saved from stenting while patency was high and TLR rates were acceptably low.

Prospective Observational Study of Sleep and PTSD Symptoms in Patients Undergoing PTSD Treatment

2009 ◽  
Author(s):  
Ihori Kobayashi ◽  
Brian Hall ◽  
Courtney Hout ◽  
Vanessa Springston ◽  
Patrick Palmieri
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Ptsd Symptoms ◽  
Ptsd Treatment

Information for Helping Drivers Achieve Safe and Enjoyable Driving: An On-Road Observational Study

2009 ◽  
Author(s):  
Muneo Kitajima ◽  
Motoyuki Akamatsu ◽  
Yasunori Maruyama ◽  
Kouichi Kuroda ◽  
Kazuhito Katou ◽  
...  
Keyword(s):  
Observational Study
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