Histological evaluation of effectiveness of platelet-rich fibrin on healing of sinus membrane perforations: A preclinical animal study

2017 ◽  
Vol 45 (8) ◽  
pp. 1150-1157 ◽  
Author(s):  
Ceyhun Aricioglu ◽  
Dogan Dolanmaz ◽  
Alparslan Esen ◽  
Kubilay Isik ◽  
Mustafa Cihat Avunduk
Keyword(s):  
Animal Study ◽  
Histological Evaluation ◽  
Platelet Rich Fibrin ◽  
Preclinical Animal Study ◽  
Sinus Membrane

Novel self-expandable, stent-based transcatheter pulmonic valve: A preclinical animal study

2014 ◽  
Vol 173 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Gi Beom Kim ◽  
Hong-Gook Lim ◽  
Yong Jin Kim ◽  
Eun Young Choi ◽  
Bo Sang Kwon ◽  
...  
Keyword(s):  
Animal Study ◽  
Pulmonic Valve ◽  
Preclinical Animal Study

scholarly journals Repair of the Perforated Sinus Membrane with Platelet Rich Fibrin: A Case Report

2016 ◽  
Vol 12 (2) ◽  
pp. 63-68
Author(s):  
Nuray Yılmaz Altıntaş ◽  
Ümmügülsüm Coşkun ◽  
Yavuz Tolga Korkmaz ◽  
Bahar Eren Kuru
Keyword(s):  
Case Report ◽  
Platelet Rich Fibrin ◽  
Sinus Membrane

New Thrombolytic Brush Catheter in Thrombosed Polytetrafluoroethylene Dialysis Grafts: Preclinical Animal Study

1998 ◽  
Vol 9 (5) ◽  
pp. 793-798 ◽  
Author(s):  
Flavio Castañeda ◽  
Patrick L. Wyffels ◽  
Jitendra C. Patel ◽  
James L. Swischuk ◽  
Ruizong Li ◽  
...  
Keyword(s):  
Animal Study ◽  
Preclinical Animal Study

scholarly journals Safety and effectiveness of a novel generator algorithm for bipolar vessel sealing: a randomised controlled chronic animal study

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bernhard Kraemer ◽  
Christos Tsaousidis ◽  
Stephan Kruck ◽  
Martin Schenk ◽  
Marcus Scharpf ◽  
...  
Keyword(s):  
Animal Study ◽  
Clinical Success ◽  
Lateral Spread ◽  
Histological Evaluation ◽  
Vascular Bundles ◽  
The Novel ◽  
Success Rates ◽  
Vessel Sealing ◽  
Thermal Spread

Abstract Background Electrosurgical vessel sealers are gradually replacing conventional techniques such as ligation and clipping. Algorithms that control electrosurgical units (ESU), known as modes, are important for applications in different surgical disciplines. This chronic porcine animal study aimed to evaluate the safety and effectiveness of the novel thermoSEAL electrosurgical vessel sealing mode (TSM). The BiClamp® mode (BCM) of the renowned VIO® 300 D ESU served as control. BCM has been widely available since 2002 and has since been successfully used in many surgical disciplines. The TSM, for the novel VIO® 3 ESU, was developed to reduce sealing time and/or thermal lateral spread adjacent to the seal while maintaining clinical success rates. The primary aim of this study was to investigate the long-term and intraoperative seal quality of TSM. Methods The BiCision® device was used for vessel sealing with TSM and BCM in ten German Landrace pigs which underwent splenectomy and unilateral nephrectomy during the first intervention of the study. The seals were cut with the BiCision® knife. Ninety-nine arteries, veins and vascular bundles were chronically sealed for 5 or 21 days. Thereafter, during the second and terminal intervention of the study, 97 additional arteries and veins were sealed. The carotid arteries were used for histological evaluation of thermal spread. Results After each survival period, no long-term complications occurred with either mode. The intraoperative seal failure rates, i.e. vessel leaking or residual blood flow after the first sealing activation, were 2% with TSM versus 6% with BCM (p = 0.28). The sealing time was significantly shorter with TSM (3.5 ± 0.69 s vs. 7.3 ± 1.3 s, p < 0.0001). The thermal spread and burst pressure of arteries sealed with both modes were similar (p = 0.18 and p = 0.61) and corresponded to the histological evaluation. The measured tissue sticking parameter was rare with both modes (p = 0.33). Tissue charring did not occur. Regarding the cut quality, 97% of the seals were severed in the first and 3% in the second attempt (both with TSM and BCM). Conclusions The novel TSM seals blood vessels twice as fast as the BCM while maintaining excellent tissue effect and clinical success rates. Trial registration Not applicable.

A preclinical animal study of a novel, simple, and secure duct and vessel occluder for laparoscopic surgery

2018 ◽  
Vol 32 (7) ◽  
pp. 3311-3320
Author(s):  
Amir Szold ◽  
Arnold Miller ◽  
Nir Lilach ◽  
Ana-Maria Botero-Anug ◽  
Raanan Miller ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Animal Study ◽  
Preclinical Animal Study

Preclinical animal study of the NIPRO-ventricular assist device for use in pediatric patients

2017 ◽  
Vol 21 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Noritsugu Naito ◽  
Yoshiaki Takewa ◽  
Satoru Kishimoto ◽  
Kei Iizuka ◽  
Toshihide Mizuno ◽  
...  
Keyword(s):  
Animal Study ◽  
Ventricular Assist Device ◽  
Pediatric Patients ◽  
Assist Device ◽  
Ventricular Assist ◽  
Preclinical Animal Study

The evaluation of a novel technique to treat saphenous vein incompetence: preclinical animal study to examine safety and efficacy of a new vein occlusion device

2012 ◽  
Vol 29 (1) ◽  
pp. 16-24 ◽  
Author(s):  
A Farber ◽  
A Belenky ◽  
M Malikova ◽  
O Brenner ◽  
Z Brandeis ◽  
...  
Keyword(s):  
Animal Study ◽  
Saphenous Vein ◽  
Fibrous Tissue ◽  
Duplex Ultrasound ◽  
Histopathological Analysis ◽  
Novel Technique ◽  
Vein Occlusion ◽  
Occlusion Device ◽  
Preclinical Animal Study

Objectives We tested a novel technique to treat great saphenous vein (GSV) incompetence in an animal model. Methods V-block (VVT Medical Ltd, Kfar Saba, Israel), an occlusion device composed of a nitinol frame and anchoring hooks, was percutaneously deployed at the saphenofemoral junction in 12 sheep. Four of the 12 sheep were treated with adjunctive liquid sclerotherapy. Animals underwent duplex ultrasound, venography and histopathological evaluation immediately postimplantation at 30, 60 and 90 days. Results V-block was successfully deployed in all animals without adverse events. There was no device migration at follow-up. Histopathological analysis demonstrated V-block to be lodged within the GSV and surrounded by fibrous tissue in all samples. Obliteration of the GSV lumen, widespread intimal loss and multifocal medial smooth muscle loss was noted. Conclusions In this animal study V-block was deployed without complications, remained in stable position and led to GSV occlusion. This device has promise for future use in humans.

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