Predictors of the necessity for lymph node biopsy of cervical lymphadenopathy

2015 ◽  
Vol 43 (10) ◽  
pp. 2200-2204 ◽  
Author(s):  
Tadataka Tsuji ◽  
Koichi Satoh ◽  
Hiroshi Nakano ◽  
Yoshiya Nishide ◽  
Yasuhiro Uemura ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Node Biopsy

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

scholarly journals Case Report: Kikuchi: The great mimicker

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 520
Author(s):  
Kevin Bryan Lo ◽  
Anna Papazoglou ◽  
Lorayne Chua ◽  
Nellowe Candelario
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Disease Patient ◽  
Cervical Lymphadenopathy ◽  
Hematologic Malignancies ◽  
Lymph Node Biopsy ◽  
Benign Disease ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Serious Disease

Kikuchi-Fujimoto disease is a form of a benign necrotizing lymphadenitis which is most commonly misdiagnosed as tuberculosis and or lymphoma, usually more common among young adults in Asia. It is a benign disease but can mimic a lot of other disease processes spanning infectious, rheumatologic and even hematologic malignancies. Our patient presented with prolonged fever and lymphadenopathy. Initial considerations were lymphoma and a nonspecific viral infection. A CT scan showed diffuse cervical lymphadenopathy with lacrimal gland involvement. An excisional lymph node biopsy was done which revealed Kikuchi disease. Patient was given steroids with immediate response with defervescence. Kikuchi is a disease with many mimics and a complete workup is needed to exclude serious disease like malignancy.

scholarly journals Cervical-facial adenopathies in Odonto-stomatology: Study of 82 observations

2017 ◽  
Author(s):  
Boubacar Ba ◽  
Issa Konaté ◽  
Drissa Goita ◽  
Abdoulaye Kassambara ◽  
A Toure ◽  
...  
Keyword(s):  
Lymph Node ◽  
Medical Records ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
University Hospital ◽  
Tuberculous Lymphadenitis ◽  
Early Management ◽  
Node Biopsy ◽  
The University ◽  
Anatomic Region

Objective: The objective of this study is to describe the etiological profile of patients with cervical lymphadenopathy in relation to tuberculosis in our practice Odonto-stomatologique.Materials and Methods: We conducted a retrospective study over a period of four years at the University Hospital of Stomatology Odonto (CHU OS) Bamako. The successive cases of cervical lymphadenopathy of tuberculous origin confirmed by skin test (TST) to tuberculin 10 units or lymph node biopsy for histological referred. Data were collected from medical records and entered and analyzed with the software Epiinfo.fr 6.0Results: The lesions involved 82 patients including 37 men (45.1%) with a sex ratio of 1.21. The age group most represented was that of 20 and 29 years (28%). The anatomic region was privileged bilateral cervical (57.30%).Our patients underwent chest radiography in 90.20% of cases. The IDR was performed in 72% of patients and tuberculous lymphadenitis and follicular caseo was found in 8.50% of cases.Conclusion: Our study revealed a prevalence of 0.31% of cervical-facial adenopathies of which 80.50% was tuberculous. In the case of tuberculous endemic tuberculous adenopathy, an IDRT and anatomopathological examination of the lymph node biopsy should be systematic for the early management of tuberculosis

scholarly journals Kikuchi–Fujimoto Disease Associated With Mycoplasma Pneumoniae Infection

2021 ◽  
pp. 014556132110442
Author(s):  
Rui-Bin Yu ◽  
Yi-Jia Chen ◽  
Chun-Hsiang Chang ◽  
Yen-Lin Chen ◽  
Jeng-Wen Chen
Keyword(s):  
Lymph Node ◽  
Antibiotic Treatment ◽  
Mycoplasma Pneumoniae ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Asian Women ◽  
Limited Disease ◽  
Node Biopsy ◽  
Mycoplasma Pneumoniae Infection

Kikuchi–Fujimoto disease (KFD) is a self-limited disease that is more common in young Asian women. Typical presentations included fever and cervical lymphadenopathy. The etiology of KFD is unknown, and diagnosis is based mainly on lymph node biopsy. KFD has been reported to be associated with Mycoplasma pneumoniae infection. However, the role of antibiotic treatment is unclear. We reported 2 cases of KFD associated with Mycoplasma pneumoniae infection and were successfully treated with a macrolide.

scholarly journals A young girl with chronic isolated cervical lymphadenopathy found to have lupus lymphadenopathy, progressing to develop lupus nephritis: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
K. P. Jayawickreme ◽  
S. Subasinghe ◽  
S. Weerasinghe ◽  
L. Perera ◽  
P. Dissanayaka
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lymph Node ◽  
Lupus Nephritis ◽  
Diagnostic Criteria ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Lower Limbs ◽  
Systemic Lupus ◽  
Node Biopsy

Abstract Background Systemic lupus erythematosus is a rare autoimmune disorder, with the prevalence in Asia ranging from 30 to 50/100,000. The diagnosis of systemic lupus erythematosus is made according to the 2019 European League Against Rheumatism/American College of Rheumatology classification criteria, and it does not contain lymphadenopathy as diagnostic criteria. However, lupus lymphadenopathy has an estimated prevalence of 5–7% at the onset of disease, and 12–15% at any stage of the disease. Case presentation A 19-year-old Sinhalese girl had neck nodules since the age of 5 years, which increased in size and became tender since 1 year. She had alopecia and joint stiffness for 6 months. She presented with a 5-day history of worsening joint pain, fever, and painful, enlarging cervical nodules. She had tender cervical lymphadenopathy, and a vasculitic rash on both lower limbs. She had pancytopenia, an erythrocyte sedimentation rate of 92, positive antinuclear antibody titer, and high anti-double-stranded deoxyribonucleic acid (DNA), with low C3 and C4 complements. She had a high reticulocyte count of 5%, with direct and indirect antiglobulin tests being positive, indicating autoimmune hemolytic anemia. Lymph node biopsy showed moderate reactive follicular hyperplasia, with scattered plasma cells and immunoblasts, with varying degree of coagulative necrosis, suggestive of lupus lymphadenopathy. On immunohistochemistry of the lymph node biopsy, Bcl2 was negative, excluding lymphoma. Contrast-enhanced computed tomography of abdomen and chest was normal with no hepatosplenomegaly or lymphadenopathy. Skin biopsy showed leukocytoclastic vasculitis. Later, with development of generalized edema, she was found to have impaired renal function, and renal biopsy showed lupus nephritis. She was started on hydroxychloroquine, prednisolone, and mycophenolate mofetil, and her symptoms improved and lymphadenopathy regressed. Conclusion In the case of cervical lymphadenopathy in a patient with systemic lupus erythematosus, the possibilities of lupus lymphadenopathy, Kikuchi–Fujimoto disease, and lymphoma should all be considered, after excluding secondary infection due to immunosuppression. Histology confirms the differentiation of these pathologies. It is important to differentiate the cause for lymphadenopathy in systemic lupus erythematosus as the outcome and treatment varies. Lupus lymphadenopathy is usually generalized, but isolated cervical lymphadenopathy could also rarely be the first presentation of systemic lupus erythematosus. Lupus lymphadenopathy can be the only presenting feature, and needs a high index in suspecting systemic lupus erythematosus, though it is not included in the diagnostic criteria.

scholarly journals Still’s Disease–A Case of Diagnostic Dilemma

2020 ◽  
Vol 15 (2) ◽  
pp. 240-242
Author(s):  
Md Abdur Razzak ◽  
Afsana Rahman ◽  
Quazi Audry Arafat Rahman
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Bacterial Infection ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
High Serum ◽  
Therapeutic Trial ◽  
Still’S Disease ◽  
Still's Disease ◽  
Node Biopsy

Still’s disease is an auto-inflammatory multisystem disease characterized by high spiking fever, salmon-colored rash that comes and goes, arthritis and other varieties of systemic manifestations. The puzzling fever and leukocytosis and high serum level of procalcitonin mistakenly may lead to diagnosis of severe bacterial infection or sepsis. But use of broad-spectrum antibiotic fails to improve the condition. It may mimic other multisystem autoimmune rheumatic diseases, but autoantibodies are negative. It may resemble the malignancies like leukemia and lymphoma, but lymph node biopsy and bone marrow study does not support. We have reported a case of Still’s disease in a 14-year-old young boy. Initially he presented like a viral illness, but high fever persisted for more than 4 weeks associated with body ache and skin rash withoutany arthritis. He had cervical lymphadenopathy, mild hepatosplenomegaly, pleural and pericardial effusion. He had persistent leukocytosis, high serum procalcitonin and high serum ferritin but low serum iron. Bacterial infection and sepsis were excluded, hematologic malignancy was ruled out by lymph node biopsy and bone marrow examination. There was no conclusive evidence of tuberculosis. Still a therapeutic trial was given but failed to produce any benefit. After exclusion of all the possible differentials and basing on diagnostic criteria he was diagnosed as a case of Still’s disease. With the use of steroid and immunosuppressive agent his condition improved dramatically and now he is leading a normal life. JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 240-242

scholarly journals Frequency of Infection in Cervical Lymph Node Biopsy Site using Chlorhexidine and Povidine Iodine

2018 ◽  
Vol 2 (1) ◽  
pp. 24-30
Author(s):  
Qudrat Ullah ◽  
Anam Parvaiz ◽  
Usman Ali Rehman ◽  
Asif Hanif ◽  
Sami Ullah Bhatti
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Skin Preparation ◽  
Cervical Lymph Nodes ◽  
Node Biopsy ◽  
Cervical Lymph Node Biopsy ◽  
Povidine Iodine

Abstract:Background: Lymph node are located throughout the lymphatic system, they are concentrated in certain areas of the body including head and neck. Cervical lymph nodes are lymph nodes found in the neck. Of the 800 lymph nodes in the human body, 300 are in the neck. Cervical lymph nodes are subject to several different pathological conditions including tumours, infection and inflammation.Methodology: The Povidine-iodine and chlorhexidine for preoperative skin preparation in cervical lymph node biopsy procedure were used in this study and patients were asked for follow up after a week. On follow up day their wounds were checked, assessed and withdraw all stiches and complications were recorded accordingly and analysed them. It was discussed and showed that which one of Povidine-iodine and chlorhexidine is best to use for preoperative skin preparation in cervical lymph node biopsy procedures to reduce surgical site infection and economical one.Results: Out of 150 patients, 46% (69) were males and 54% (81) were females that had cervical lymphadenopathy after skin preparation by chlorhexidine antiseptic solution showed frequency of infection in total of 150 patients 16.67% (25) were infected while the other 83.33%(125) were not infected. Out of 150 patients who were underwent cervical lymphadenopathy after using povidine iodine skin preparatory antiseptic solution, 42% (63) were males and 58% (87) were females and among those frequency of infection showed 44.67% (67) were infected while the others 55.33% (83) were not.Conclusion: Preoperative scrubbing of the patient’s skin with chlorhexidine–alcohol is better than scrubbing with povidone–iodine for preventing surgical-site infection after cervical lymph node biopsy.

scholarly journals Role of Fine needle aspiration cytology in the diagnosis of Cervical lymphadenopathy

1970 ◽  
Vol 11 (1) ◽  
pp. 25-27
Author(s):  
AH Kafi ◽  
HB Arif ◽  
AS Ruhul
Keyword(s):  
Lymph Node ◽  
Frozen Section ◽  
Cervical Lymphadenopathy ◽  
Neck Surgery ◽  
Needle Aspiration ◽  
Lymphoid Hyperplasia ◽  
Lymph Node Biopsy ◽  
College Hospital ◽  
Node Biopsy ◽  
Set Up

Objective: A study was carried out to know the overall prevalence of various causes responsible for cervical lymphadenopathy of more than 3 weeks duration. FNAC has been evaluated as a diagnostic tool in our clinical set up. We aimed to present 120 cases which we treated in our center within last 4 years. Methods: A retrospective study has been carried out from August 2007 to August 2011 in the department of Otolaryngology and Head-Neck Surgery at CMH Rangpur, Apollo Hospitals Dhaka And Ibn Sina Medical College Hospital Dhaka. All patients presented with cervical lymphadenopathy of more than 3 weeks duration. FNAC has been done for all suspected cases. CT neck has been done in 4 cases for deep jugular nodes. 60 patients underwent lymph node biopsy as FNAC report was non-specific lymphadenitis. For three cases we have done frozen section biopsy. Preoperative workup with routine blood tests, Xray chest and tuberculin tests have been carried out for all cases. Results: Out of 120 FNAC of cervical lymphadenopathy - 60 were non-specific lymphadenitis, 34 were tuberculosis, 13 were metastatic (with 2 occult primary), 7 were lymphomas (Immunocytochemistry proved ) and 6 were abscess. All 60 non-specific lymphadenopathy cases (FNAC report) underwent lymph node biopsy.5 cases were consistent with tuberculosis , 1 was lymphoma and rest were reactive . For 3 cases frozen section biopsy have been done. One was consistent with granulomatous disease and two cases were diagnosed as lymphoid hyperplasia. Both the lymphoid hyperplasia cases have been diagnosed as Castleman's disease after histopathology report. Conclusion: The study concluded the fact that the non-specific infection is the most common cause of cervical lymphadenopathy followed by tuberculosis .Supplemented with routine laboratory investigations, FNAC give very important clue to the physicians that can be routinely used in patients with cervical lymphadenopathy. DOI: http://dx.doi.org/10.3329/bjms.v11i1.9818 BJMS 2012; 11(1): 25-27

scholarly journals The Diagnostic Yield of Excisional Biopsy in Cervical Lymphadenopathy: A Retrospective Analysis of 158 Biopsies in Adults

2021 ◽  
pp. 014556132110230
Author(s):  
Mohamed Bassiouni ◽  
Gyeongphill Kang ◽  
Heidi Olze ◽  
Steffen Dommerich ◽  
Philipp Arens
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Retrospective Analysis ◽  
Malignant Disease ◽  
Diagnostic Yield ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Lymph Node Biopsy ◽  
Adult Patients ◽  
Node Biopsy

Objectives: Cervical lymph nodes are the most common site of peripheral lymphadenopathy. The underlying etiologies are usually benign and self-limiting but may include malignancies or other severe life-threatening diseases. The aim of the current study was to investigate the various underlying pathologies of cervical lymphadenopathy as assessed by the diagnostic yield of excisional lymph node biopsies of the neck in a tertiary adult practice. The evaluation was performed in light of previous literature and regional epidemiological patterns. Methods: Retrospective analysis of hospital charts of 158 adult patients who underwent an excisional biopsy for suspected cervical lymphadenopathy at a tertiary referral head and neck service between January 2017 and December 2019. Results: The most common underlying pathology was unspecific and/or reactive lymphadenitis in 44.5% of specimens, followed by malignant disease in 38.6% of cases. An age above 40 years was significantly correlated with an increased likelihood of malignant disease. Lower jugular and posterior triangle lymph nodes showed higher malignancy rates than other groups (100% and 66.7%, respectively). The overall surgical complication rate was 2.5%. Conclusions: The results of the current study serve as an indicator of the variety of etiologies causing cervical lymphadenopathy. In particular, given the increasing incidence of malignant diseases in recent decades, the findings should alert physicians to the importance of lymph node biopsy for excluding malignancy in persistent cervical lymphadenopathy especially in older adults. The findings emphasize the value of excisional lymph node biopsy of the neck as a useful diagnostic tool in adult patients with peripheral lymphadenopathy.

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