Lack of association of matrix metalloproteinase-9 promoter gene polymorphism in obstructive sleep apnea syndrome

2015 ◽  
Vol 43 (7) ◽  
pp. 1099-1103 ◽  
Author(s):  
Mustafa Yalcınkaya ◽  
Selim S. Erbek ◽  
Seda Turkoglu Babakurban ◽  
Elif Kupeli ◽  
Serife Bozbas ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Matrix Metalloproteinase ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Promoter Gene ◽  
Apnea Syndrome ◽  
Metalloproteinase 9

scholarly journals Matrix Metalloproteinase-9 Is a Predictive Factor for Systematic Hypertension and Heart Dysfunction in Patients with Obstructive Sleep Apnea Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Shuhui Wang ◽  
Shisheng Li ◽  
Bin Wang ◽  
Jiajia Liu ◽  
Qinglai Tang
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Cardiovascular Diseases ◽  
Matrix Metalloproteinase ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Metalloproteinase 9

Patients with obstructive sleep apnea syndrome (OSAS) showed higher prevalence in cardiovascular diseases due to aberrant hypoxia and oxidative stress. However, not all OSAS patients end up with cardiovascular disorders, and identification of novel biomarker will be invaluable for differentiating patients at risk. Here we tested the serum matrix metalloproteinase-9 (MMP-9) levels in 47 untreated OSAS patients and found that the MMP-9 level was positively correlated with severity of OSAS, which was consistent with hypoxia degree and duration. Besides, the MMP-9 level was higher in patients complicated with systematic hypertension (P < 0.001). Furthermore, we selected those OSAS patients without any cardiovascular dysfunction (n=35) and followed up for up to five years. By the end of follow-up, 12 patients had hypertension onset and 3 patients had left ventricular hypertrophy. By analyzing the clinical outcomes with MMP-9 expression, we demonstrated that high serum MMP-9 in OSAS patients was a risk factor for occurrence of cardiovascular diseases. In addition, we cultured the vascular endothelial cells (VEC) from rat aorta in hypoxia condition to investigate whether MMP-9 was elevated due to hypoxia in OSAS patients. Cellular results revealed that the expression, secretion, and activity of MMP-9 were all upregulated by hypoxia and can cleave the beta2-adrenergic receptor (β2AR) on VEC surface. Our results not only determined MMP-9 as a risk factor for cardiovascular diseases in OSAS patients, but also showed the possible involvement of hypoxia-MMP-9-β2AR signaling axis.

Association of GABABR1 Receptor Gene Polymorphism with Obstructive Sleep Apnea Syndrome

ORL ◽  
2007 ◽  
Vol 69 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Yildirim A. Bayazit ◽  
Metin Yılmaz ◽  
Oguz Kokturk ◽  
M. Emin Erdal ◽  
Tansu Ciftci ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Obstructive Sleep Apnea Syndrome ◽  
Receptor Gene ◽  
Sleep Apnea Syndrome ◽  
Receptor Gene Polymorphism ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Insulin Receptor Substrate Gene Polymorphism Is Associated With Obstructive Sleep Apnea Syndrome in Men

2006 ◽  
Vol 116 (11) ◽  
pp. 1962-1965 ◽  
Author(s):  
Yildirim A. Bayazit ◽  
Mehmet Emin Erdal ◽  
Metin Yilmaz ◽  
Tansu Ulukavak Ciftci ◽  
Fatma Soylemez ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Insulin Receptor ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Insulin Receptor Substrate ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Association of Serotonin Transporter Gene Polymorphism with Obstructive Sleep Apnea Syndrome

2005 ◽  
Vol 115 (5) ◽  
pp. 832-836 ◽  
Author(s):  
Metin Ylmaz ◽  
Yildirim A. Bayazit ◽  
Tansu Ulukavak Ciftci ◽  
M Emin Erdal ◽  
Meral Urhan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gene Polymorphism ◽  
Obstructive Sleep Apnea Syndrome ◽  
Serotonin Transporter ◽  
Sleep Apnea Syndrome ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Obstructive Sleep ◽  
Apnea Syndrome
Sign in / Sign up

Export Citation Format

Share Document