Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement

2015 ◽  
Vol 43 (6) ◽  
pp. 751-757 ◽  
Author(s):  
Zhonglong Liu ◽  
Zao Fang ◽  
Tianguo Dai ◽  
Chenping Zhang ◽  
Jian Sun ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adenoid Cystic Carcinoma ◽  
Distant Metastasis ◽  
Lymph Node Ratio ◽  
Positive Lymph Node ◽  
Nodal Involvement ◽  
Free Survival ◽  
Adenoid Cystic ◽  
Distant Metastasis Free Survival ◽  
Node Ratio

Tumour immune characterization in adenoid cystic carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15191-e15191
Author(s):  
Shengjin Dou ◽  
Di Chen ◽  
Rongrong Li ◽  
Yining Yang ◽  
Ning He ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Survival Time ◽  
Distant Metastasis ◽  
Cox Regression ◽  
Expression Profiles ◽  
Univariate Analysis ◽  
Free Survival ◽  
Immune Infiltration ◽  
Adenoid Cystic ◽  
Distant Metastasis Free Survival

e15191 Background: Here, we profiled genetic hallmarks of Chinese adenoid cystic carcinoma (ACC) patients and immune cells infiltration levels by gene expression-based computational methods to investigate the correlation with immunotherapy. Methods: 54 patients with pathologically confirmed ACC admitted from January 2016 to October 2019 were included. Mutation and expression profiles were obtained by whole-exome sequencing (WES) and RNA-seq, respectively. A nomogram that integrated clinicopathological features with the immune signature to predict recurrence or distant metastasis probability was constructed by multivariate Cox regression. Results: As expected, we observed MYB fusion and somatic mutations in our cohort (57%, 31/54), strengthening the role of these aberrations as critical events in ACC. Mutations in NOTCH1 were also found in our cohort (19%, 10/54). Median tumour mutational burden (TMB) of these patients is 0.85 Muts/Mbp (0-11 Muts/Mbp). Analysis of WES data showed that all patients were microsatellite instability (MSI)-negative, and 17 of them were confirmed by conventional MSI-PCR testing. Lack of PD-L1 expression is 96.0% (n = 46/48) at a tumour proportion score 0% and 22.9% (11/48) of cases showed more than 10% CD8+ prevalence. We compared cancer types using an immune infiltration score (IIS) and an antigen presenting machinery expression (APM) score and find that ACC is among the lowest for both scores. Statistically significant correlations were found between IIS and distant metastasis-free survival (univariate analysis, HR = 2.64, 95% confidence interval [CI], 1.134 to 6.145, p = 0.023). Patients with higher IIS had shorter distant metastasis-free survival time (log-rank p = 0.020), and patients with higher T cell infiltration score (TIS) had shorter locoregional recurrence-free survival time (log-rank p = 0.050). In addition, we investigated the pretreatment immune profile of five ACC patients treated with PD-1 checkpoint inhibitors, and found that both TIS and APM were elevated in responding patient (with a partial response to camrelizumab) whereas they were in the lowest for patients with progressive disease on camrelizumab or pembrolizumab. Conclusions: Our study highlights the immune infiltration patterns and unravels mRNA signatures with prognostic utility and immunotherapeutic biomarker potential in ACC.

High Expression of H3K9me3 Is a Strong Predictor of Poor Survival in Patients With Salivary Adenoid Cystic Carcinoma

2013 ◽  
Vol 137 (12) ◽  
pp. 1761-1769 ◽  
Author(s):  
Ronghui Xia ◽  
Rongrui Zhou ◽  
Zhen Tian ◽  
Chunye Zhang ◽  
Lizhen Wang ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Distant Metastasis ◽  
Survival Data ◽  
Histone H3 ◽  
Disease Free Survival ◽  
Rank Test ◽  
Free Survival ◽  
Salivary Adenoid Cystic Carcinoma ◽  
Adenoid Cystic ◽  
Disease Free

Context.—Histone methylation and acetylation play important roles in the carcinogenesis and progression of cancer. Objective.—To investigate whether histone modifications influence the prognosis of patients with salivary adenoid cystic carcinoma (ACC). Design.—The expression of histone H3 lysine 9 trimethylation (H3K9me3) and histone H3 lysine 9 acetylation (H3K9Ac) was assessed by immunohistochemistry in 66 specimens of primary ACC. Tests were used to determine the presence of any correlation between H3K9me3 and H3K9Ac levels and clinicopathologic parameters. Log-rank test and Cox proportional hazards regression models were used to analyze the survival data. Results.—H3K9me3 expression was positively correlated with solid pattern tumors (P = .002) and distant metastasis (P = .001). Solid pattern tumors had lower H3K9Ac expression levels than cribriform-tubular pattern tumors (P = .03). Patients whose tumors showed high H3K9me3 expression and a solid pattern had a significantly poorer overall survival (OS) (P < .001 and P < .001, respectively) and disease-free survival (P < .001 and P = .01, respectively). Low H3K9Ac expression was correlated with poor OS (P = .05). The multivariate analysis indicated that high levels of H3K9me3 expression and solid pattern tumors were independent prognostic factors that significantly influenced OS (P = .004 and P = .04, respectively). H3K9me3 expression was identified as the only independent predictor of disease-free survival (P = .006). Conclusions.—Our results suggest that high levels of H3K9me3 expression are predictive of rapid cell proliferation and distant metastasis in ACC. Compared with histologic patterns, H3K9me3 might be a better predictive biomarker for the prognosis of patients with salivary ACC.

Comparison of positive lymph node ratio with an inflammation-based prognostic score in colorectal cancer

2010 ◽  
Vol 98 (2) ◽  
pp. 282-286 ◽  
Author(s):  
S. J. Moug ◽  
G. McColl ◽  
S. M. Lloyd ◽  
G. Wilson ◽  
J. D. Saldanha ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Prognostic Score ◽  
Positive Lymph Node ◽  
Node Ratio
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