Oral cancer treatment and immune targets – A role for dendritic cells?

2012 ◽  
Vol 40 (2) ◽  
pp. 103-104 ◽  
Author(s):  
Hans-Robert Metelmann ◽  
Peter Hyckel ◽  
Fred Podmelle
Keyword(s):  
Dendritic Cells ◽  
Oral Cancer ◽  
Cancer Treatment

scholarly journals DCision-making in tumors governs T cell anti-tumor immunity

Oncogene ◽  
2021 ◽  
Author(s):  
Francesca Alfei ◽  
Ping-Chih Ho ◽  
Wan-Lin Lo
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
Cancer Treatment ◽  
Tumor Immunity ◽  
T Cell Activation ◽  
Cell Activation ◽  
Genetic Alterations ◽  
Immune Checkpoint Blockade ◽  
Oncological Treatment

AbstractThe exploitation of T cell-based immunotherapies and immune checkpoint blockade for cancer treatment has dramatically shifted oncological treatment paradigms and broadened the horizons of cancer immunology. Dendritic cells have emerged as the critical tailors of T cell immune responses, which initiate and coordinate anti-tumor immunity. Importantly, genetic alterations in cancer cells, cytokines and chemokines produced by cancer and stromal cells, and the process of tumor microenvironmental regulation can compromise dendritic cell–T cell cross-talk, thereby disrupting anti-tumor T cell responses. This review summarizes how T cell activation is controlled by dendritic cells and how the tumor microenvironment alters dendritic cell properties in the context of the anti-tumor immune cycle. Furthermore, we will highlight therapeutic options for tailoring dendritic cell-mediated decision-making in T cells for cancer treatment.

scholarly journals PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques

2016 ◽  
Vol 127 (4) ◽  
pp. E124-E131 ◽  
Author(s):  
Nathan Handley ◽  
Jacob Eide ◽  
Randall Taylor ◽  
Beverly Wuertz ◽  
Patrick Gaffney ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Treatment

Intraprostatic administration of autologous dendritic cells for prostate cancer treatment

2002 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Alexandre Zlotta ◽  
Michel Toungouz ◽  
Micheline Lambermont ◽  
Pierre Hoffman ◽  
Christian Garbar
Keyword(s):  
Prostate Cancer ◽  
Dendritic Cells ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment

Nanotechnology in Oral Cancer Treatment

2021 ◽  
pp. 369-379
Author(s):  
Chandramani B. More ◽  
Rahi M. Brahmbhatt ◽  
Naman R. Rao
Keyword(s):  
Oral Cancer ◽  
Cancer Treatment

scholarly journals 13-gene DNA Methylation Analysis from Oral Brushing: A Promising Non Invasive Tool in the Follow-up of Oral Cancer Patients

2019 ◽  
Vol 8 (12) ◽  
pp. 2107 ◽  
Author(s):  
Davide B. Gissi ◽  
Achille Tarsitano ◽  
Andrea Gabusi ◽  
Roberto Rossi ◽  
Giuseppe Attardo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Oral Cancer ◽  
Cancer Treatment ◽  
Sample Collection ◽  
Methylation Analysis ◽  
Non Invasive ◽  
Locoregional Relapse ◽  
Positive Score ◽  
Dna Methylation Analysis

Background: This study aimed to evaluate the prognostic value of a non-invasive sampling procedure based on 13-gene DNA methylation analysis in the follow-up of patients previously treated for oral squamous cell carcinoma (OSCC). Methods: The study population included 49 consecutive patients treated for OSCC. Oral brushing sample collection was performed at two different times: before any cancer treatment in the tumor mass and during patient follow-up almost 6 months after OSCC treatment, within the regenerative area after OSCC resection. Each sample was considered positive or negative in relation to a predefined cut-off value. Results: Before any cancer treatment, 47/49 specimens exceeded the score and were considered as positive. Six months after OSCC resection, 16/49 specimens also had positive scores in the samples collected from the regenerative area. During the follow-up period, 7/49 patients developed locoregional relapse: 6/7 patients had a positive score in the regenerative area after OSCC resection. The presence of a positive score after oral cancer treatment was the most powerful variable related to the appearance of locoregional relapse. Conclusion: 13-gene DNA methylation analysis by oral brushing may have a clinical application as a prognostic non-invasive tool in the follow-up of patients surgically treated for OSCC.

Follow‐up after oral cancer treatment transition to a personalised approach

2020 ◽  
Author(s):  
Marieke Brands ◽  
André Verbeek ◽  
Sandra Geurts ◽  
Thijs Merkx
Keyword(s):  
Oral Cancer ◽  
Cancer Treatment

SUN-PO110: Basic Investigation on the Mechanisms of Action of Elemental Diet Elental® in Oral Cancer Treatment

2019 ◽  
Vol 38 ◽  
pp. S100
Author(s):  
K. Harada ◽  
R. Fujiwara ◽  
T. Hisano ◽  
T. Takenawa ◽  
K. Mishima
Keyword(s):  
Oral Cancer ◽  
Cancer Treatment ◽  
Elemental Diet ◽  
Mechanisms Of Action ◽  
Basic Investigation
Sign in / Sign up

Export Citation Format

Share Document