scholarly journals Elevated Mitral Valve Pressure Gradient After MitraClip Implantation Deteriorates Long-Term Outcome in Patients With Severe Mitral Regurgitation and Severe Heart Failure

2017 ◽  
Vol 10 (9) ◽  
pp. 931-939 ◽  
Author(s):  
Michael Neuss ◽  
Thomas Schau ◽  
Akihiro Isotani ◽  
Markus Pilz ◽  
Maren Schöpp ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Pressure Gradient ◽  
Severe Heart Failure ◽  
Severe Mitral Regurgitation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Valve Pressure

Results of Coronary Bypass and Valve Operations for Mitral Valve Regurgitation

2007 ◽  
Vol 15 (5) ◽  
pp. 396-404 ◽  
Author(s):  
Srikrishna Sirivella ◽  
Isaac Gielchinsky
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Coronary Bypass ◽  
Mitral Valve Regurgitation ◽  
Left Ventricular ◽  
Valve Regurgitation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Coronary Bypass Grafting

Combined coronary bypass grafting and valve procedures for mitral valve regurgitation result in poor outcomes, but the impact of the etiology of valve regurgitation on operative and long-term outcomes is not well defined. A retrospective analysis of 468 patients who had combined coronary bypass grafting and valve operations for mitral regurgitation showed that 78% had valve repairs and 22% had replacements for ischemic (45%) or degenerative (55%) disease. Predictors of operative mortality were ischemic mitral regurgitation, failure to use the internal mammary artery for grafting, severe coronary disease, acute myocardial infarction, low ejection fraction, advanced heart failure, emergency operation, and mitral valve replacement. The 5-year survival rates for propensity-matched patients with ischemic or degenerative disease were similar (66%). Low ejection fraction (< 35%), advanced age (> 67 years), valve replacement surgery, residual mitral regurgitation, and severe coronary artery disease were predictors of poor long-term outcome. Although the operative outcomes of ischemic mitral regurgitation were poor compared to those of degenerative disease, the long-term survival was similar in both groups of propensity-matched patients. Left ventricular remodeling, an optimal valve procedure without residual mitral regurgitation, and left ventricular function are more important determinants of long-term outcome than the etiology of valve regurgitation.

P4724Elevated mitral valve pressure gradient is predictive for long-term outcome after percutaneous edge-to-edge mitral valve repair (PMVR) in patients with degenerative MR, but not in functional MR

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Patzelt ◽  
W Zhang ◽  
R Sauter ◽  
M Mezger ◽  
H Nording ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Cox Regression ◽  
Regression Analyses ◽  
Valve Repair ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Patient Cohort ◽  
Kaplan Meier ◽  
Valve Pressure

Abstract Background To analyze the effects of residual mitral regurgitation (MR) and mean mitral valve pressure gradient (MVPG) after percutaneous edge-to-edge mitral valve repair (PMVR) using the MitraClip-system on long term outcome. Methods and results Two hundred fifty-five patients who underwent PMVR were analyzed. Kaplan-Meier and Cox regression analyses were performed to evaluate the impact of residual MR and MVPG on clinical outcome. A combined clinical endpoint (all-cause mortality, MV surgery, redo procedure, implantation of a left ventricular assist device) was used. After PMVR, mean MVPG increased from 1.6±1.0 mmHg to 3.1±1.5 mmHg (p<0.001). Reduction of MR severity to ≤2+ postintervention was achieved in 98.4% of all patients. In the overall patient cohort, residual MR was predictive for the combined endpoint while elevated MVPG >4.4 mmHg was not according to Kaplan-Meier and Cox regression analyses. We then analyzed the cohort with degenerative and that with functional MR separately to account for these different entities.In the cohort with degenerative MR, elevated MVPG was associated with increased occurrence of the primary endpoint, whereas this was not observed in the cohort with functional MR. Conclusions MVPG >4.4 mmHg after MitraClip-implantation was predictive for clinical outcome in the patient cohort with degenerative MR. In the patient cohort with functional MR, MVPG >4.4 mmHg was not associated with increased clinical events. Acknowledgement/Funding This study was supported by grants from the German Research Foundation (KFO 274), the Volkswagen Foundation (Lichtenberg Program) and the German Heart

scholarly journals 0562: Long term outcome of patients with benfluorex-induced mitral regurgitation and first episode of heart failure

2015 ◽  
Vol 7 (1) ◽  
pp. 57
Author(s):  
Pierre-Philippe Nicol ◽  
Florent Le Ven ◽  
Yves Etienne ◽  
Isabelle Quintin-Roué ◽  
Eric Bezon ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mitral Regurgitation ◽  
First Episode ◽  
Term Outcome ◽  
Long Term Outcome
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