scholarly journals CRT-200.29 Evaluation Of Lesion Flow Coefficient For The Detection Of Coronary Artery Disease In Patient Groups From Two Academic Medical Centers

2017 ◽  
Vol 10 (3) ◽  
pp. S38
Author(s):  
Srikara Viswanath Peelukhana ◽  
Rupak Banerjee ◽  
Tim P. van de Hoef ◽  
Kranthi Kolli ◽  
Mohamed Effat ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Flow Coefficient ◽  
Academic Medical Centers ◽  
Medical Centers ◽  
Academic Medical ◽  
Patient Groups ◽  
Artery Disease ◽  
Lesion Flow Coefficient

scholarly journals Lower Antiplatelet Effect of Aspirin in Essential Thrombocythemia than in Coronary Artery Disease

TH Open ◽  
2021 ◽  
Vol 05 (03) ◽  
pp. e230-e238
Author(s):  
Oliver Buchhave Pedersen ◽  
Anne-Mette Hvas ◽  
Hans Beier Ommen ◽  
Steen Dalby Kristensen ◽  
Erik Lerkevang Grove
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Platelet Aggregation ◽  
Essential Thrombocythemia ◽  
Antiplatelet Effect ◽  
Immature Platelet Fraction ◽  
Increased Risk ◽  
Platelet Disorder ◽  
Patient Groups ◽  
Artery Disease

Abstract Background Patients with essential thrombocythemia (ET) and coronary artery disease (CAD) have increased risk of thromboembolic complications. In addition, a reduced antiplatelet effect of aspirin has been demonstrated in both patient groups. As ET is a platelet disorder, platelets may be more important for the thromboembolic risk in ET than in CAD. We aimed to investigate the antiplatelet effect of aspirin and platelet turnover in ET versus CAD patients. Methods We included 48 ET patients and an age-matched group of 48 CAD patients. The effect of aspirin was evaluated by thromboxane B2 (TXB2) levels and platelet aggregation. Platelet turnover was assessed by immature platelet count (IPC) and immature platelet fraction (IPF). Results ET patients had reduced effect of aspirin compared with CAD patients, demonstrated by significantly higher TXB2 levels (median of differences = 22.3 ng/mL, p < 0.0001) and platelet aggregation (median of differences = 131.0 AU*min, p = 0.0003). Furthermore, ET patients had significantly higher IPC (p < 0.0001) and IPF (p = 0.0004) than CAD patients. Conclusion ET patients have lower 24-hour antiplatelet effect of aspirin than CAD patients. This may be explained by an increased platelet production and turnover counteracting the antiplatelet effect of aspirin. These findings strengthen the rationale for exploring novel antiplatelet regimens in ET patients to reduce the risk of cardiovascular events.

scholarly journals Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Ji-Ren Peng ◽  
Ting-Ting Lu ◽  
Hao-Teng Chang ◽  
Xuan Ge ◽  
Bian Huang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Levels ◽  
Protein Quantification ◽  
Superoxide Dismutases ◽  
Coronary Syndrome ◽  
Patient Groups ◽  
Artery Disease ◽  
And Gender ◽  
And Control

Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD).Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP,n=33), patients with acute coronary syndrome (ACS,n=49), and controls (n=42). Protein quantification was done using ELISA.Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis.Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.

scholarly journals The Importance of the Autopsy in Medicine: Perspectives of Pathology Colleagues

2019 ◽  
Vol 6 ◽  
pp. 237428951983404 ◽  
Author(s):  
Louis Maximilian Buja ◽  
Rolf F. Barth ◽  
Gerhard R. Krueger ◽  
Sergey V. Brodsky ◽  
Robert L. Hunter
Keyword(s):  
Viral Infections ◽  
Academic Medical Centers ◽  
Positive Side ◽  
Medical Centers ◽  
Academic Medical ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Artery Disease ◽  
Physician Scientists ◽  
Formalin Fixed

This article presents a perspective on the importance of the autopsy in medical practice and science based on experiences of the authors as physician-scientists involved in autopsy practice. Our perspectives are presented on the seminal contributions of the autopsy in the areas of cardiovascular disease, including congenital heart disease, atherosclerosis, coronary artery disease, and myocardial infarction, and infectious disease, including tuberculosis and viral infections. On the positive side of the future of the autopsy, we discuss the tremendous opportunities for important research to be done by application of advanced molecular biological techniques to formalin-fixed, paraffin-embedded tissue blocks obtained at autopsy. We also note with concern the countervailing forces impacting the influence of pathology in education and clinical practice at our academic medical centers, which also present impediments to increasing autopsy rates. Our challenge as academic pathologists, whose careers have been molded by involvement in the autopsy, is to counter these trends. The challenges are great but the benefits for medicine and society are enormous.

Baseline cognitive performance in three patient groups with coronary artery disease

2002 ◽  
Vol 73 (1) ◽  
pp. S377
Author(s):  
L.M. Borowicz ◽  
M.A. Grega ◽  
O.A. Selnes ◽  
S. Quaskey ◽  
M.A. Martin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cognitive Performance ◽  
Patient Groups ◽  
Artery Disease

scholarly journals Coronary Artery Disease Reporting and Data System (CAD-RADS) Adoption: Analysis of Local Trends in a Large Academic Medical Center

2021 ◽  
Vol 3 (3) ◽  
pp. e210016
Author(s):  
Angelo K. Takigami ◽  
Vikas Thondapu ◽  
Reece J. Goiffon ◽  
Jena Depetris ◽  
Sumit Gupta ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Medical Center ◽  
Academic Medical Center ◽  
Data System ◽  
Disease Reporting ◽  
Academic Medical ◽  
Artery Disease

Serum BUN/Cr comparisons in three patient groups with coronary artery disease

2002 ◽  
Vol 73 (1) ◽  
pp. S370
Author(s):  
L.M. Borowicz ◽  
M.A. Grega ◽  
O.A. Selnes ◽  
S. Quaskey ◽  
M.A. Martin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Patient Groups ◽  
Artery Disease

Abstract P164: Health Status Outcomes in Patients With Non-Obstructive Coronary Artery Disease

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Rosanna Tavella ◽  
Natalie Cutri ◽  
John F Beltrame
Keyword(s):  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Health Outcomes ◽  
Short Form ◽  
Obstructive Coronary Artery Disease ◽  
Summary Score ◽  
Sf 36 ◽  
Patient Groups ◽  
Artery Disease

BACKGROUND. Approximately 20-30% of coronary angiograms undertaken for the investigation of chest pain show non-obstructive coronary artery disease (NoCAD). These patients receive little attention compared to their counterparts with obstructive coronary artery disease (CAD). The current study assessed the health outcomes of patients with NoCAD as compared with CAD over 12 months. METHOD. Consecutive patients undergoing angiography for the investigation of chest pain were recruited prior to the procedure. The following health outcomes were evaluated at baseline, 1, 6 and 12 months: (a) chest pain, (b) Seattle Angina Questionnaire (SAQ), and (c) Short-Form 36 (SF-36). RESULTS. Of the 1148 patients with chest pain recruited, 320 (28%) had NoCAD. Compared with CAD, these patients were younger (62 11 vs 57 12 years, respectively, p <0.001) and following age-adjusted analysis, were more likely to be female (29 vs 58%, respectively, p < 0.001). Baseline SF-36 and SAQ scores were similar for the two groups. Over 12 months, both patient groups showed an improvement in SF36 and SAQ scores. However, the change in SF-36 Physical Summary Score at 12 months compared to baseline was significantly lower in NoCAD patients (see plot). No longitudinal differences were seen in SAQ domain scores. Self reported chest pain was lower in the CAD patients compared with NoCAD at 1 (64% vs 68%, p>0.05), 6 (46% vs 61%, p <0 .001) and 12 months (40% vs 48%, p>0.05). CONCLUSION. Patients with NoCAD are younger and more likely to be female. After adjusting for age, they are more likely to have ongoing chest pain and impaired quality of life as assessed by the SF-36.

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