scholarly journals CRT-800.21 Triple Antithrombotic Therapy in High Bleeding Risk Population Has Higher Bleeding But Similar Stroke Rate Following Transcatheter Aortic Valve Implantation

2017 ◽  
Vol 10 (3) ◽  
pp. S69-S70
Author(s):  
M. Chadi Alraies ◽  
Kyle Buchanan ◽  
Edward Koifman ◽  
Homam Moussa Pacha ◽  
Arie Steinvil ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Antithrombotic Therapy ◽  
Bleeding Risk ◽  
Stroke Rate ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
High Bleeding Risk ◽  
Valve Implantation ◽  
Triple Antithrombotic Therapy

Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation

Heart ◽  
2019 ◽  
Vol 105 (10) ◽  
pp. 742-748 ◽  
Author(s):  
Vincent Johan Nijenhuis ◽  
Jorn Brouwer ◽  
Lars Søndergaard ◽  
Jean-Philippe Collet ◽  
Erik Lerkevang Grove ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Aortic Valve ◽  
Aortic Arch ◽  
Transcatheter Aortic Valve Implantation ◽  
Oral Anticoagulation ◽  
Antithrombotic Therapy ◽  
Coronary Syndrome ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation

This review provides a comprehensive overview of the available data on antithrombotic therapy after transcatheter aortic valve implantation (TAVI). In the absence of large randomised clinical trials, clinical practice is leaning towards evidence reported in other populations. Due to the greater risk of major bleeding associated with oral anticoagulation using a vitamin-K antagonist (VKA), antiplatelet therapy (APT) may be considered as the first-line treatment of patients undergoing TAVI. Overall, single rather than dual APT is preferred. However, dual APT should be considered in patients with a recent acute coronary syndrome (ie, within 6 months), complex coronary stenting, large aortic arch atheromas or previous non-cardioembolic stroke. Monotherapy with VKA should be considered if concomitant atrial fibrillation or any other indication for long-term oral anticoagulation is present. APT on top of VKA seems only reasonable in patients with recent acute coronary syndrome, extensive or recent coronary stenting or large aortic arch atheromas. A direct-acting oral anticoagulant may be considered if oral anticoagulation is indicated in the absence of contraindications. Initiation of VKA is indicated in clinical valve thrombosis, for example, with high transvalvular gradient, whereas the role of VKA in the case of subclinical leaflet thrombosis is currently uncertain.

scholarly journals Transcatheter Aortic Valve Implantation and Subclinical and Clinical Leaflet Thrombosis: Multimodality Imaging for Diagnosis and Risk Stratification

2021 ◽  
Vol 16 ◽  
Author(s):  
María Martín ◽  
Javier Cuevas ◽  
Helena Cigarrán ◽  
Juan Calvo ◽  
César Morís
Keyword(s):  
Aortic Valve ◽  
Risk Stratification ◽  
Transcatheter Aortic Valve Implantation ◽  
Treatment Strategy ◽  
Antithrombotic Therapy ◽  
Multimodality Imaging ◽  
Transcatheter Aortic Valve ◽  
Prevention And Treatment ◽  
Aortic Valve Implantation ◽  
Valve Implantation

In recent years, the phenomenon of subclinical leaflet thrombosis (SLT) in patients who have undergone transcatheter aortic valve implantation has become increasingly relevant. Hypo-attenuating leaflet thickening and hypo-attenuation affecting motion diagnosed by CT are the hallmarks of SLT, and their incidence varies depending on the intensity of screening. Whether these phenomena are a surrogate for leaflet thrombosis reducing valve durability and increasing the risk of stroke is still a matter of debate. Uncertainty remains over the optimal antithrombotic therapy after TAVI and the best treatment strategy is still not confirmed. Ongoing and future trials will provide more evidence about the best strategy for the prevention and treatment of SLT.

scholarly journals Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation

2021 ◽  
Vol 16 (3) ◽  
pp. 7
Author(s):  
A.I. Mironova ◽  
E.S. Kropacheva ◽  
A.E. Komlev ◽  
M.I. Makeev ◽  
T.E. Imaev ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Antithrombotic Therapy ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation
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