scholarly journals CRT-300.16 Drug-Eluting Balloon Expandable Stents for Below-The-Knee Revascularization in Patients With Critical Limb Ischemia. The Need for Better Therapies

2016 ◽  
Vol 9 (4) ◽  
pp. S38
Author(s):  
Manuel A. Gonzalez ◽  
Enrique Filgueiras ◽  
Glenn Barquet ◽  
Francis Crespo ◽  
Gibert Gonzalez ◽  
...  
Keyword(s):  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Below The Knee ◽  
Drug Eluting ◽  
Drug Eluting Balloon

Abstract 16656: Drug Eluting Balloon Versus Percutaneous Transluminal Angioplasty Below the Knee Intervention for Critical Limb Ischemia: A Meta-analysis of Randomized Controlled Trials

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Muhammad Khalid ◽  
Mahmoud El Iskandarani ◽  
Vijay Ramu ◽  
Michael Donovan ◽  
Terry Forrest ◽  
...  
Keyword(s):  
Critical Limb Ischemia ◽  
Meta Analysis ◽  
Limb Ischemia ◽  
Target Lesion ◽  
Major Amputation ◽  
Transluminal Angioplasty ◽  
Below The Knee ◽  
All Cause Mortality ◽  
Drug Eluting ◽  
Drug Eluting Balloon

Introduction: Studies have shown decrease rates of restenosis and target lesion revascularization (TLR) with drug eluting balloon (DEB) in diabetic patients with critical limb ischemia (CLI). Hypothesis: The aim of this meta-analysis to compare the efficacy of DEB versus Percutaneous transluminal angioplasty (PTA) below the knee peripheral intervention. Methods: Electronic databases including MEDLINE, ClinicalTrials.gov and the Cochrane Library were searched for all randomized controlled trials (RCTs) published until April 2020 comparing outcomes of DEB vs PTA in patients with CLI below the knee. End points were major amputation, major adverse events (MAEs), all-cause mortality, target lesion revascularization (TLR), myocardial infarction, and cerebrovascular accidents (CVA). The risk ratio (RR) with 95% confidence interval (CI) were computed and p <0.05 was considered as a level of significance. Results: A total of 4 RCTs (n=655) were included in the final analysis. There were no differences of major amputation (RR: 1.30; CI: 0.68-2.46; p=0.43), MAEs (RR: 0.86; CI: 0.60-1.23; p=0.41), all-cause mortality (RR: 0.91; CI: 0.69-1.19; p=0.48), TLR (RR: 0.65; CI: 0.30-1.44; p=0.29), MI (RR: 1.71; CI: 0.57-5.14; p=0.34) and CVA (RR: 0.66; CI: 0.19-2.26; p=0.50) between the 2 groups [Figure 1]. Conclusions: There were no significant differences of major amputation and TLR for DEB versus PTA . Major adverse cardiac, cerebrovascular events and all-cause mortality were not statistically different for drug coated balloon versus PTA in the management of below knee critical limb ischemia. Further studies needed to confirm these findings.

scholarly journals Preventing Leg Amputations in Critical Limb Ischemia With Below-the-Knee Drug-Eluting Stents

2010 ◽  
Vol 55 (15) ◽  
pp. 1580-1589 ◽  
Author(s):  
Andrew J. Feiring ◽  
Mari Krahn ◽  
Lori Nelson ◽  
Amy Wesolowski ◽  
Daniel Eastwood ◽  
...  
Keyword(s):  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Drug Eluting Stents ◽  
Below The Knee ◽  
Drug Eluting

scholarly journals Drug-Eluting Balloon Versus Standard Balloon Angioplasty for Infrapopliteal Arterial Revascularization in Critical Limb Ischemia

2014 ◽  
Vol 64 (15) ◽  
pp. 1568-1576 ◽  
Author(s):  
Thomas Zeller ◽  
Iris Baumgartner ◽  
Dierk Scheinert ◽  
Marianne Brodmann ◽  
Marc Bosiers ◽  
...  
Keyword(s):  
Balloon Angioplasty ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Arterial Revascularization ◽  
Drug Eluting ◽  
Drug Eluting Balloon
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