Autoantibodies to p75/LEDGF, a cell survival factor, found in patients with atypical retinal degeneration

2006 ◽  
Vol 27 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Marian S. Chin ◽  
Rafael C. Caruso ◽  
Barbara Detrick ◽  
John J. Hooks
Keyword(s):  
Cell Survival ◽  
Retinal Degeneration ◽  
Survival Factor ◽  
A Cell ◽  
Cell Survival Factor

scholarly journals Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor

2010 ◽  
Vol 21 (4) ◽  
pp. 499-500 ◽  
Author(s):  
Martin A. Schwartz
Keyword(s):  
Cell Survival ◽  
Cancer Metastasis ◽  
Control Cell ◽  
Integrin Signaling ◽  
Tumor Resistance ◽  
Survival Factor ◽  
Response To Chemotherapy ◽  
A Cell ◽  
Resistance To Chemotherapy ◽  
Cell Survival Factor

In 1992, Jere Meredith and I followed up on a serendipitous observation and showed that matrix deprivation can lead to apoptosis. Our article in Molecular Biology of the Cell, together with work form Steve Frisch's lab, helped establish the paradigm that integrin signals control cell survival in a variety of systems. It has been a pleasure to watch that work take on a life of its own as other investigators have explored its role in processes such as cavitation, regression of the mammary gland at the end of pregnancy, cancer metastasis, and tumor resistance to chemotherapy. Recently, we described an exception to the paradigm: In some tumors, reagents that activate integrin signaling enhance apoptosis in response to chemotherapy.

scholarly journals The extracellular matrix as a cell survival factor.

1993 ◽  
Vol 4 (9) ◽  
pp. 953-961 ◽  
Author(s):  
J E Meredith ◽  
B Fazeli ◽  
M A Schwartz
Keyword(s):  
Extracellular Matrix ◽  
Cell Death ◽  
Cell Survival ◽  
Tyrosine Phosphatase ◽  
Cell Types ◽  
Specific Gene ◽  
Survival Factor ◽  
A Cell ◽  
Cell Growth And Differentiation ◽  
Cell Survival Factor

Programmed cell death (PCD) or apoptosis is a naturally occurring cell suicide pathway induced in a variety of cell types. In many cases, PCD is induced by the withdrawal of specific hormones or growth factors that function as survival factors. In this study, we have investigated the potential role of the extracellular matrix (ECM) as a cell survival factor. Our results indicate that in the absence of any ECM interactions, human endothelial cells rapidly undergo PCD, as determined by cell morphology, nuclei fragmentation, DNA degradation, protein cross-linking, and the expression of the PCD-specific gene TRPM-2. PCD was blocked by plating cells on an immobilized integrin beta 1 antibody but not by antibodies to either the class I histocompatibility antigen (HLA) or vascular cell adhesion molecule-1 (VCAM-1), suggesting that integrin-mediated signals were required for maintaining cell viability. Treatment of the cells in suspension with the tyrosine phosphatase inhibitor sodium orthovanadate also blocked PCD. When other cell types were examined, some, but not all, underwent rapid cell death when deprived of adhesion to the ECM. These results suggest that in addition to regulating cell growth and differentiation, the ECM also functions as a survival factor for many cell types.

scholarly journals Whole Transcriptome Profiling Identifies CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160970 ◽  
Author(s):  
Iana H. Haralambieva ◽  
Michael T. Zimmermann ◽  
Inna G. Ovsyannikova ◽  
Diane E. Grill ◽  
Ann L. Oberg ◽  
...  
Keyword(s):  
Antibody Response ◽  
Cell Survival ◽  
Plasma Cell ◽  
Specific Antibody ◽  
Transcriptome Profiling ◽  
Specific Antibody Response ◽  
Survival Factor ◽  
Whole Transcriptome ◽  
Cell Survival Factor

Lens Epithelium-Derived Growth Factor (LEDGF/p75) is a cancer cell survival factor that controls the expression of decoy TRAIL-receptor 2 (DcR2)

Apmis ◽  
2008 ◽  
Vol 116 (5) ◽  
pp. 413-413
Author(s):  
Lou Klitgaard Povlsen ◽  
Mads Daugaard ◽  
Mikkel Rohde ◽  
Jakob E. Larsen ◽  
Marja Jäättelä
Keyword(s):  
Growth Factor ◽  
Cell Survival ◽  
Cancer Cell ◽  
Lens Epithelium ◽  
Trail Receptor ◽  
Survival Factor ◽  
Cancer Cell Survival ◽  
Cell Survival Factor

Demonstration of multiple novel glycoforms of the stem cell survival factor CCg

2004 ◽  
Vol 77 (1) ◽  
pp. 9-14 ◽  
Author(s):  
A. Dahl ◽  
P.S. Eriksson ◽  
P. Davidsson ◽  
A.I. Persson ◽  
R. Ekman ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Survival Factor ◽  
Stem Cell Survival ◽  
Cell Survival Factor

A Potential Th2 Cell Survival Factor, Amphiregulin Production Is Enhanced Following Neurotransmitter Signaling

2013 ◽  
Vol 131 (2) ◽  
pp. AB192
Author(s):  
Kanami Orihara ◽  
Sonia S. Charran ◽  
Kent T. HayGlass ◽  
Redwan Moqbel
Keyword(s):  
Cell Survival ◽  
Survival Factor ◽  
Th2 Cell ◽  
Cell Survival Factor
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