scholarly journals Solvent-free MALDI-MS: Developmental improvements in the reliability and the potential of MALDI in the analysis of synthetic polymers and giant organic molecules

2006 ◽  
Vol 17 (5) ◽  
pp. 661-671 ◽  
Author(s):  
S. Trimpin ◽  
S. Keune ◽  
H. J. Räder ◽  
K. Müllen
Keyword(s):  
Organic Molecules ◽  
Synthetic Polymers ◽  
Solvent Free ◽  
Maldi Ms

Solvent-Free Iodination of Organic Molecules Using the I2/Urea—H2O2 Reagent System.

ChemInform ◽  
2007 ◽  
Vol 38 (27) ◽  
Author(s):  
Jasminka Pavlinac ◽  
Marko Zupan ◽  
Stojan Stavber
Keyword(s):  
Organic Molecules ◽  
Solvent Free

Mechanochemistry for sustainable, efficient dehydrogenation/hydrogenation

2020 ◽  
Author(s):  
Blaine G. Fiss ◽  
Austin James Richard ◽  
Tomislav Friscic ◽  
Audrey Moores
Keyword(s):  
Ball Milling ◽  
Chemical Industry ◽  
Organic Molecules ◽  
Solvent Free ◽  
Chemical Transformations ◽  
Triple Bonds ◽  
Bulk Chemicals ◽  
Challenges And Opportunities ◽  
Hydrogenation Reactions ◽  
Solution Routes

Hydrogenation reactions are one of the pillars of the chemical industry, with applications from bulk chemicals to pharmaceuticals manufacturing. The ability to selectively add hydrogen across double and/or triple bonds is key in the chemist’s toolbox, and the enabling component in the development of sustainable processes. Traditional solution-based approaches to hydrogenation reactions are tainted by significant consumption of energy and production of solvent waste. This review highlights the development and applications of recently emerged solvent-free approaches to conduct the hydrogenation of organic molecules using mechanochemistry, i.e. chemical transformations induced or sustained by mechanical force. In particular, we will show how mechanochemical techniques such as ball-milling enable catalytic or stoichiometric metal-mediated hydrogenation reactions that are simple, fast, and are conducted under significantly milder conditions compared to traditional solution routes. Importantly, we highlight the current challenges and opportunities in this field, while also identifying exciting cases in which mechanochemical hydrogenation strategies lead to new, unique targets and reactivity.

scholarly journals Ozone-Mediated Amine Oxidation and Beyond: A Solvent Free, Flow-Chemistry Approach

2021 ◽  
Author(s):  
Eric Skrotzki ◽  
Jaya Kishore Vandavasi ◽  
Stephen Newman
Keyword(s):  
Organic Molecules ◽  
Flow Chemistry ◽  
Packed Bed ◽  
High Reactivity ◽  
Solvent Free ◽  
Packed Bed Reactor ◽  
Primary Amines ◽  
Amine Oxidation ◽  
Synthetic Utility ◽  
Free Oxidation

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to over-oxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time of this reaction to achieve improved control and chemoselectivity over this challenging reaction. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C–H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.<br>

Characterization of synthetic polymers by MALDI-MS

2006 ◽  
Vol 31 (3) ◽  
pp. 277-357 ◽  
Author(s):  
Giorgio Montaudo ◽  
Filippo Samperi ◽  
Maurizio S. Montaudo
Keyword(s):  
Synthetic Polymers ◽  
Maldi Ms

scholarly journals Derivatization of Aminoglycoside Antibiotics with Tris(2,6-dimethoxyphenyl)carbenium Ion

Acta Naturae ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 128-135 ◽  
Author(s):  
A. P. Topolyan ◽  
M. A. Belyaeva ◽  
E. E. Bykov ◽  
P. V. Coodan ◽  
E. A. Rogozhin ◽  
...  
Keyword(s):  
Organic Molecules ◽  
Positive Charge ◽  
Aminoglycoside Antibiotics ◽  
Maldi Ms ◽  
Amino Groups ◽  
Uv Detectors ◽  
Aromatic Residue ◽  
Amide Bonds ◽  
Carbenium Ion

Detection of aminoglycoside antibiotics by MS or HPLC is complicated, because a) carbohydrate molecules have low ionization ability in comparison with other organic molecules (particularly in MALDI-MS), and b) the lack of aromatics and/or amide bonds in the molecules makes common HPLC UV-detectors useless. Here, we report on the application of a previously developed method for amine derivatization with tris(2,6-dimethoxyphenyl)carbenium ion to selective modification of aminoglycoside antibiotics. Only amino groups bound to primary carbons get modified. The attached aromatic residue carries a permanent positive charge. This makes it easy to detect aminoglycoside antibiotics by MS-methods and HPLC, both as individual compounds and in mixtures.

Peer Reviewed: Characterizing Synthetic Polymers by MALDI MS

1998 ◽  
Vol 70 (13) ◽  
pp. 456A-461A ◽  
Author(s):  
Kuang Jen Wu ◽  
Robert W. Odom
Keyword(s):  
Synthetic Polymers ◽  
Maldi Ms
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