Cytologic Features of False Negative Axillary Lymph Node Fine Needle Aspiration Smears from Patients with Breast Cancer: An Attempt to Define Adequacy Criteria

2016 ◽  
Vol 5 (5) ◽  
pp. S11-S12
Author(s):  
Andrea Jones ◽  
Sarah Kerr
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Axillary Lymph Node ◽  
False Negative ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Fine Needle

The Role of Axillary Lymph Node Fine Needle Aspiration in Breast Cancer Staging prior to Chemotherapy with Histological Correlation

2012 ◽  
Vol 56 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Sara E. Monaco ◽  
Amy Colaizzi ◽  
Anisa Kanbour ◽  
Ahmed S. Ibrahim ◽  
Amal Kanbour-Shakir
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Axillary Lymph Node ◽  
Cancer Staging ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Fine Needle ◽  
Breast Cancer Staging

scholarly journals Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Isabela Panzeri Carlotti Buzatto ◽  
Francisco José Cândido dos Reis ◽  
Jurandyr Moreira de Andrade ◽  
Tamara Cristina Gomes Ferraz Rodrigues ◽  
Jéssica Maria Camargo Borba ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Axillary Lymph Node ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Axillary Ultrasound ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Abstract Background Axillary lymph node involvement is one important prognostic factor in breast cancer, but the way to access this information has been modified over the years. This study evaluated if axillary ultrasound (US) coupled with fine-needle aspiration cytology (FNAC) can accurately predict clinically relevant node metastasis in patients with breast cancer, and thus assist clinical decisions Methods This is a cross-sectional study with retrospective data collection of 241 individuals (239 women and 2 men) with unilateral operable breast cancer who were submitted to preoperative axillary assessment by physical exam, US and FNAC if suspicious nodes by imaging. We calculated sensitivity, specificity, and accuracy of the methods. We compared the patient's characteristics using chi-square test, parametrics and non-parametrics statistics according to the variable. Results The most sensible method was US (0.59; 95% CI, 0.50–0.69), and the most specific was US coupled with FNAC (0.97; 95% CI, 0.92–0.99). Only 2.7% of the patients with normal axillary US had more than 2 metastatic nodes in the axillary lymph node dissection, against 50% of the patients with suspicious lymph nodes in the US and positive FNAC. Conclusions Axillary US coupled with FNAC can sort patients who have a few metastatic nodes at most from those with heavy axillary burden and could be one more tool to initially evaluate patients and define treatment strategies.

scholarly journals Shortcomings of ultrasound-guided fine needle aspiration in the axillary management of women with breast cancer

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Michel Attieh ◽  
Faek Jamali ◽  
Ghina Berjawi ◽  
Mothana Saadeldine ◽  
Fouad Boulos
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Axillary Lymph Node ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Ultrasound Guided ◽  
Fine Needle

Abstract Background Ultrasound, along with ultrasound-guided fine needle aspiration, is currently used for the axillary evaluation of breast cancer patients in order to identify candidates for axillary lymph node dissection. The aim of this study is to evaluate the accuracy of this tool in correctly identifying patients who may or may not benefit from axillary clearance in light of the ACOSOG Z0011 trial recommendations. Methods One hundred one patients (65 with positive US-FNA with corresponding axillary lymph node dissection (ALND), and 36 with negative US-FNA with corresponding ALND/sentinel lymph node biopsy) were studied for the number of involved axillary lymph nodes, tumor clinicopathologic features, and axillary radiologic findings. Results From the positive US-FNA group, 43% of patients had two or fewer positive lymph nodes upon ALND pathologic examination. In the US-FNA negative group, the negative predictive value for detecting axillary disease was 72.7%. With both groups combined, the sensitivity, specificity, PPV, and NPV of US-FNA for selecting patients based on axillary disease burden were 86%, 51.7%, 57%, and 83.3%, respectively. Conclusion Based on Z0011 guidelines, US-FNA is not a reliable tool in triaging patients in need for ALND and leads to overtreatment of 43% patients when positive, while depriving a small but significant percentage of patients from necessary therapy, when negative.

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