Colouring materials of pre-Columbian codices: non-invasive in situ spectroscopic analysis of the Codex Cospi

2012 ◽  
Vol 39 (3) ◽  
pp. 672-679 ◽  
Author(s):  
C. Miliani ◽  
D. Domenici ◽  
C. Clementi ◽  
F. Presciutti ◽  
F. Rosi ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Non Invasive

Efficiency of diagnosis and treatment non-invasive and microinvasive sgamous cell cervical cancer

2020 ◽  
pp. 71-74
Author(s):  
M.M. Melnyk ◽  
◽  
S.V. Nespradko ◽  
I.V. Goncharuk ◽  
M.V. Marchenko ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Key Words ◽  
National Cancer Institute ◽  
Reproductive Function ◽  
Diagnosis And Treatment ◽  
Non Invasive ◽  
Corpus Uteri ◽  
Complex Program ◽  
Early Cervical Cancer

The objective: analyse the effectiveness of diagnosis and treatment for early cervical cancer. Materials and methods. Analysed 107 cases of women’s disease on CIN ІІІ, cancer in situ, they were on treatment in National cancer institute and Kyiv dictrict cancer dispensary from 2010 till 2015 years. Results. Diagnosed percent relapse CIN ІІІ, cancer in situ contain 4.57% uninvasive and invasive form – 0.94%. Conclusion. According diagnostic CIN ІІ and CIN ІІІ is recommended to do treatment conization and dynamic dispensary observation. Are making complex program of infection HPV16, 18. In appering of margins resection some elements of tumor after wider conization by forms of cancer in situ. Many of expansive burns in cervical glands, in making of reproductive function, going disease (nodel leiomyoma of corpus uteri etc). In perspective is accept the notion of looking after and screening research of considering infection HPV16, 18 on CIN І, CIN ІІ. Key words: cervical cancer, сancer in situ, CIN І–ІІІ, diagnostic, treatment, conization.

scholarly journals New from Old: Thorectandrin Alkaloids in a Southern Australian Marine Sponge, Thorectandra choanoides (CMB-01889)

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 97
Author(s):  
Shamsunnahar Khushi ◽  
Angela A. Salim ◽  
Ahmed H. Elbanna ◽  
Laizuman Nahar ◽  
Robert J. Capon
Keyword(s):  
Marine Sponge ◽  
Tissue Specificity ◽  
Spectroscopic Analysis ◽  
Transformation Products ◽  
Chemical Fractionation ◽  
Cancer Tissue ◽  
Michael Acceptor ◽  
Michael Acceptors ◽  
Stable Ring

Thorectandra choanoides (CMB-01889) was prioritized as a source of promising new chemistry from a library of 960 southern Australian marine sponge extracts, using a global natural products social (GNPS) molecular networking approach. The sponge was collected at a depth of 45 m. Chemical fractionation followed by detailed spectroscopic analysis led to the discovery of a new tryptophan-derived alkaloid, thorectandrin A (1), with the GNPS cluster revealing a halo of related alkaloids 1a–1n. In considering biosynthetic origins, we propose that Thorectandrachoanoides (CMB-01889) produces four well-known alkaloids, 6-bromo-1′,8-dihydroaplysinopsin (2), 6-bromoaplysinopsin (3), aplysinopsin (4), and 1′,8-dihydroaplysinopsin (10), all of which are susceptible to processing by a putative indoleamine 2,3-dioxygenase-like (IDO) enzyme to 1a–1n. Where the 1′,8-dihydroalkaloids 2 and 10 are fully transformed to stable ring-opened thorectandrins 1 and 1a–1b, and 1h–1j, respectively, the conjugated precursors 3 and 4 are transformed to highly reactive Michael acceptors that during extraction and handling undergo complete transformation to artifacts 1c–1g, and 1k–1n, respectively. Knowledge of the susceptibility of aplysinopsins as substrates for IDOs, and the relative reactivity of Michael acceptor transformation products, informs our understanding of the pharmaceutical potential of this vintage marine pharmacophore. For example, the cancer tissue specificity of IDOs could be exploited for an immunotherapeutic response, with aplysinopsins transforming in situ to Michael acceptor thorectandrins, which covalently bind and inhibit the enzyme.

scholarly journals Optical nanomanipulation on solid substrates via optothermally-gated photon nudging

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jingang Li ◽  
Yaoran Liu ◽  
Linhan Lin ◽  
Mingsong Wang ◽  
Taizhi Jiang ◽  
...  
Keyword(s):  
Colloidal Particles ◽  
Solid Substrate ◽  
Optical Scattering ◽  
Functional Nanostructures ◽  
Non Invasive ◽  
Solid Substrates ◽  
All Optical ◽  
Scattering Force ◽  
Reconfigurable Assembly

AbstractConstructing colloidal particles into functional nanostructures, materials, and devices is a promising yet challenging direction. Many optical techniques have been developed to trap, manipulate, assemble, and print colloidal particles from aqueous solutions into desired configurations on solid substrates. However, these techniques operated in liquid environments generally suffer from pattern collapses, Brownian motion, and challenges that come with reconfigurable assembly. Here, we develop an all-optical technique, termed optothermally-gated photon nudging (OPN), for the versatile manipulation and dynamic patterning of a variety of colloidal particles on a solid substrate at nanoscale accuracy. OPN takes advantage of a thin surfactant layer to optothermally modulate the particle-substrate interaction, which enables the manipulation of colloidal particles on solid substrates with optical scattering force. Along with in situ optical spectroscopy, our non-invasive and contactless nanomanipulation technique will find various applications in nanofabrication, nanophotonics, nanoelectronics, and colloidal sciences.

Possibility of in situ spectroscopic analysis for iron rust on the running band of rail

Wear ◽  
2008 ◽  
Vol 265 (9-10) ◽  
pp. 1396-1401 ◽  
Author(s):  
Yasutomo Sone ◽  
Junichi Suzumura ◽  
Takumi Ban ◽  
Fusayoshi Aoki ◽  
Makoto Ishida
Keyword(s):  
Spectroscopic Analysis

Non-invasive in-situ analysis of a wreath of gold leaves from the National Archaeological Museum of Taranto, Italy

Measurement ◽  
2018 ◽  
Vol 126 ◽  
pp. 164-167 ◽  
Author(s):  
Alessandro Buccolieri ◽  
Eva Degl'Innocenti ◽  
Roberto Cesareo ◽  
Alfredo Castellano ◽  
Giovanni Buccolieri
Keyword(s):  
In Situ Analysis ◽  
Non Invasive

Żelazna Nowa, stanowisko 2. Cmentarzysko kultury przeworskiej z Zapilcza na południowym Mazowszu

2020 ◽  
Author(s):  
Małgorzata Cieślak-Kopyt ◽  
Dorota Pogodzińska
Keyword(s):  
Material Culture ◽  
Archaeological Heritage ◽  
Non Invasive ◽  
Vistula River ◽  
Animal Bones ◽  
The Subject ◽  
Metal Detectors ◽  
Przeworsk Culture ◽  
Small Finds

The subject of the monograph, published as the 10th volume of the Saved Archaeological Heritage series, are the results of rescue excavations on a cemetery from the period of Roman influence on the Vistula River near Magnuszew in southern Mazovia (Poland), carried out several years ago at the initiative of the Museum in Radom. This necropolis, like many similar ones throughout the country, was systematically destroyed as a result of agricultural activities, and in recent years also through illegal prospection with the use of metal detectors. Archaeologists, with the cooperation of numerous volunteers, managed to protect against further destruction about 60 graves (urned and urnless) from the period between the 1st century BC and the 3rd century CE. These are an evidence of the settlement of the region by people whose material traces are referred to in the archaeological nomenclature as the Przeworsk culture (associated mainly with the Germanic tribes). The cinerary graves were equipped with ceramics, metal parts of clothing, tools, less often weapons, glass beads, imported vessels or dice. Among the forms of graves, the so-called groove object stands out: a kind of rectangular grave feature tied with survival to the beginnings of our era of Celtic traditions, arriving here from northern Małopolska. In addition to the standard catalogue with the description of graves, pottery and small finds, and very detailed illustration plates, the monograph includes an analysis of material culture and forms of burial, photographs of selected finds and very extensive specialist reports. The latter include both osteological materials (anatomo-anthropological analysis, analysis of animal bones placed in the graves), as well as other ecofacts and individual categories of furnishings (glass, faience, iron and bronze objects). The whole is complemented by clear plans with the location of graves and artifacts in the necropolises, as well as with the results of non-invasive research going far beyond the excavated area and of key importance for further in situ protection of this extremely valuable monument.

scholarly journals Online process monitoring of a batch distillation by medium field NMR spectroscopy

2021 ◽  
Author(s):  
Anne Friebel ◽  
Erik von Harbou ◽  
Kerstin Münnemann ◽  
Hans Hasse
Keyword(s):  
Process Monitoring ◽  
Binary Systems ◽  
Spectroscopic Analysis ◽  
Ternary Systems ◽  
Ethyl Formate ◽  
Batch Distillation ◽  
Non Invasive ◽  
Robust Measurements ◽  
Online Process Monitoring ◽  
Online Process

Medium field NMR spectrometers are attractive for online process monitoring. Therefore, in the present work, a single-stage laboratory batch distillation still was coupled online with a medium field NMR spectrometer. This enables quantitative non-invasive measurements without calibration. The technique was used for studying isobaric and isothermal residue curves in two ternary systems: (dimethyl sulfoxide + acetonitrile + ethyl formate) and (ethyl acetate + acetone + diethyl ether) and boiling curves and high-boiling azeotropes in two binary systems: (acetic acid + pyridine) and (methanol + diethylamine). The results of the online NMR spectroscopic analysis were compared to results from offline analysis as well as to results from thermodynamic modeling using NRTL parameters that were parametrized with literature data. The new method for online process monitoring gives reliable results and is well-suited for fast and robust measurements of residue curves.

scholarly journals Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

2021 ◽  
Author(s):  
Shinsuke Oda ◽  
Masayoshi Fujisawa ◽  
Li Chunning ◽  
Toshihiro Ito ◽  
Takahiro Yamaguchi ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Cancer Progression ◽  
Mapk Pathway ◽  
Negative Regulator ◽  
Mitogen Activated Protein Kinase ◽  
Ki67 Index ◽  
Erk Activation ◽  
Non Invasive ◽  
Erk Mapk

Aberrant activation of the Ras/Raf/ERK (extracellular-signal-regulated kinase)-MAPK (mitogen-activated protein kinase) pathway is involved in the progression of cancer, including urothelial carcinoma; but the negative regulation remains unclear. In the present study, we investigated pathological expression of Spred2 (Sprouty-related EVH1 domain-containing protein 2), a negative regulator of the Ras/Raf/ERK-MAPK pathway, and the relation to ERK activation and Ki67 index in various categories of 275 urothelial tumors obtained from clinical patients. In situ hybridization demonstrated that Spred2 mRNA was highly expressed in high-grade non-invasive papillary urothelial carcinoma (HGPUC), and the expression was decreased in carcinoma in situ (CIS) and infiltrating urothelial carcinoma (IUC). Immunohistochemically, membranous Spred2 expression, important to interact with Ras/Raf, was preferentially found in HGPUC. Interestingly, membranous Spred2 expression was decreased in CIS and IUC relative to HGPUC, while ERK activation and the expression of the cell proliferation marker Ki67 index were increased. HGPUC with membranous Spred2 expression correlated significantly with lower levels of ERK activation and Ki67 index as compared to those with negative Spred2 expression. Thus, our pathological findings suggest that Spred2 negatively regulates cancer progression in non-invasive papillary carcinoma possibly through inhibiting the Ras/Raf/ERK-MAPK pathway, but this regulatory mechanism is lost in cancers with high malignancy. Spred2 appears to be a key regulator in the progression of non-invasive bladder carcinoma.

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